Additional file 3. List of grey literature relevant websites.

Additional file 4. Definitions.

Additional file 5. Stakeholder review and feedback.

Additional file 5. Stakeholder review and feedback.

Additional file 1.

Additional file 1.

Abstract Introduction Healthcare workers’ adoption of mHealth is critical to the success or failure of clinician based mHealth services in the developing world. mHealth adoption is affected or promoted by certain factors, some of which are peculiar to the developing world. Identifying these factors and evaluating them will help develop a valid and reliable measuring instrument for more successful prediction of mHealth adoption in the future. The aim of this study was to design and...

Additional file 1. Figure S1: The percentage and numbers of heart Gata3+ ILC2s in 8-week-old wild-type C57BL/6 mice. A Cumulative frequencies and enumeration of heart Gata3+ ILC2s among ILC2s (identified as CD45+Lin-CD127+CD90.2+ST2+ cells, left) or CD45+ lymphocytes (middle) in 8-week-old wild-type mice by flow cytometric analysis. B Cumulative frequencies and enumeration of heart GATA3+CD127+ ILC2s among CD45+ lymphocyte in 8-week-old wild type mice by flow cytometric analysis. Each dot represents one mouse; different colors represent...

Additional file 2. DEGs of ILC2 and its clusters between female and male mice.

Abstract Background Group 2 innate lymphoid cells (ILC2s) are the most dominant ILCs in heart tissue, and sex-related differences exist in mouse lung ILC2 phenotypes and functions; however, it is still unclear whether there are sex differences in heart ILC2s. Results Compared with age-matched wild-type (WT) male mice, 8-week-old but not 3-week-old WT female mice harbored an obviously greater percentage and number of heart ILC2s in homeostasis. However, the percentage of killer-cell lectin-like receptor G1...

Supplemental material, sj-docx-1-tam-10.1177_17588359221136759 for Immune checkpoint inhibitors plus chemotherapy in patients with locally advanced or metastatic pulmonary sarcomatoid carcinoma: a multicentric real-world study by Fei Zhou, Haoyue Guo, Xiaolong Zhou, Huikang Xie, Tian Tian, Wencheng Zhao, Guanghui Gao, Anwen Xiong, Lei Wang, Wei Li, Xiaoxia Chen, Yan Zhang, Jue Fan, Fengying Wu, Yongchang Zhang and Caicun Zhou in Therapeutic Advances in Medical Oncology

Supplemental material, sj-docx-2-tam-10.1177_17588359221136759 for Immune checkpoint inhibitors plus chemotherapy in patients with locally advanced or metastatic pulmonary sarcomatoid carcinoma: a multicentric real-world study by Fei Zhou, Haoyue Guo, Xiaolong Zhou, Huikang Xie, Tian Tian, Wencheng Zhao, Guanghui Gao, Anwen Xiong, Lei Wang, Wei Li, Xiaoxia Chen, Yan Zhang, Jue Fan, Fengying Wu, Yongchang Zhang and Caicun Zhou in Therapeutic Advances in Medical Oncology

Additional file 4. Tucidinostat plus checkpoint blockade induces significant antitumor immunity. a Schema of the experiment. Mouse CT26 cells (5 × 105 cells) were engrafted into the flank of BALB/c mice. When established tumors were palpable 7 days after tumor cells inoculation, mice were treated with vehicle (DMSO, n=7), tucidinostat (25 mg/kg, gavage, daily, n=7), aPD-L1 (200 μg, i.p. injection, once every 3 days, n=7), or combination (n=7). The proportion of intratumoral CD8+ T cells...

Additional file 4. Tucidinostat plus checkpoint blockade induces significant antitumor immunity. a Schema of the experiment. Mouse CT26 cells (5 × 105 cells) were engrafted into the flank of BALB/c mice. When established tumors were palpable 7 days after tumor cells inoculation, mice were treated with vehicle (DMSO, n=7), tucidinostat (25 mg/kg, gavage, daily, n=7), aPD-L1 (200 μg, i.p. injection, once every 3 days, n=7), or combination (n=7). The proportion of intratumoral CD8+ T cells...

Additional file 5. Tucidinostat plus checkpoint blockade induces CCL5 secretion. a Mouse CT26 cells (5 × 105 cells) were engrafted into the flank of BALB/c mice. When established tumors were palpable 7 days after tumor cells inoculation, mice were treated with different doses (12.5, 25, 75 mg/kg, gavage, daily, n=5) of tucidinostat. The expression of CCL5 in peripheral blood serum from CT26 tumor-bearing mice on day 10 post treatment initiation. Mouse CT26 cells (5 ×...

Additional file 6. The original blots.

Whether the northern margin of the North China Craton (NCC) was a continental arc or in a lithospheric extensional setting during the Carboniferous is the primary divergence among different tectonic models about the terminal evolutionary history of the southeastern Central Asian Orogenic Belt (CAOB). The Alxa block is the western segment of the northern NCC and contiguous to the southeastern CAOB, and therefore the tectonic setting of the Carboniferous magmatic intrusions in this block can...

Macroautophagy/autophagy is a conserved mechanism launched by host organisms to fight against virus infection. Double-membraned autophagosomes in arthropod vectors can be remodeled by arboviruses to accommodate virions and facilitate persistent viral propagation, but the underlying mechanism is unknown. Rice gall dwarf virus (RGDV), a plant nonenveloped double-stranded RNA virus, induces the formation of virus-containing double-membraned autophagosomes to benefit persistent viral propagation in leafhopper vectors. In this study, it was found that the capsid protein P2...

Due to the outstanding properties, magnetic particles have been widely used as magnetic carriers and adsorbents in a diverse range of fields, such as biomedical diagnostics, food safety, and environmental monitoring, etc. Sorting different magnetic particles from each other based on size simultaneously can be very useful in multiple targets separation. To the best of our knowledge, this research firstly proposes the arc comb structure microfluidic (ACSM) chip for multi-magnetic particles separation based on size...

Abstract Background Increasing rates of childhood obesity worldwide are a serious threat to the health of school-aged children. Unhealthy behavioral habits are modifiable factors in the control of childhood obesity, and personal and family factors are key influencing factors of behavioral habits in school-aged children. This study assessed the relationship between overweight/obesity, energy balance-related behaviors (EBRB), and their influencing factors in school-aged children. Methods This cross-sectional survey included 4412 primary school-aged (10–12 years) students who...

Abstract Background A functioning vascular access (VA) is crucial to providing adequate hemodialysis (HD) and considered a critically important outcome by patients and healthcare professionals. A validated, patient-important outcome measure for VA function that can be easily measured in research and practice to harvest reliable and relevant evidence for informing patient-centered HD care is lacking. Vascular Access outcome measure for function: a vaLidation study In hemoDialysis (VALID) aims to assess the accuracy and feasibility of...

Abstract Background A functioning vascular access (VA) is crucial to providing adequate hemodialysis (HD) and considered a critically important outcome by patients and healthcare professionals. A validated, patient-important outcome measure for VA function that can be easily measured in research and practice to harvest reliable and relevant evidence for informing patient-centered HD care is lacking. Vascular Access outcome measure for function: a vaLidation study In hemoDialysis (VALID) aims to assess the accuracy and feasibility of...

Additional file 1: Table S1. The taxonomy, quality, and genome size of 18 MAGs. Table S2. The taxonomy, quality, and genomic information of seven isolated strains. Table S3. The information of proteins related to CAP biotransformation in Sphingomonas sp. CL5.1 revealed by proteomics.

Additional file 2: Figure S1. The antimicrobial activity of the culture medium collected at various CAP biodegradation stages. Figure S2. Genomic characteristics of the seven isolated strains. Figure S3. The integrated analysis pipeline for multi-omics datasets. Figure S4. The KEGG enrichment analysis of DEGs and correlation analysis of DEGs with CAP as well as its metabolites. Figure S5. The HPLC-QTOF-MS chromatograms of main metabolites produced by isolated CAP-degrading strains including Sphingomonas sp. CL5.1, Caballeronia sp....

Abstract Background As a widely used broad-spectrum antibiotic, chloramphenicol is prone to be released into environments, thus resulting in the disturbance of ecosystem stability as well as the emergence of antibiotic resistance genes. Microbes play a vital role in the decomposition of chloramphenicol in the environment, and the biotransformation processes are especially dependent on synergistic interactions and metabolite exchanges among microbes. Herein, the comprehensive chloramphenicol biotransformation pathway, key metabolic enzymes, and interspecies interactions in an...