2 Works

Data from: Recurrent evolution of melanism in South American felids

Alexsandra Schneider, Corneliu Henegar, Kenneth Day, Devin Absher, Constanza Napolitano, Leandro Silveira, Victor A. David, Stephen J. O’Brien, Marilyn Menotti-Raymond, Gregory S. Barsh & Eduardo Eizirik
Morphological variation in natural populations is a genomic test bed for studying the interface between molecular evolution and population genetics, but some of the most interesting questions involve non-model organisms that lack well annotated reference genomes. Many felid species exhibit polymorphism for melanism but the relative roles played by genetic drift, natural selection, and interspecies hybridization remain uncertain. We identify mutations of Agouti signaling protein (ASIP) or the Melanocortin 1 receptor (MC1R) as independent causes...

Data from: Anthrax toxin receptor 1 is essential for arteriogenesis in a mouse model of hindlimb ischemia

Nicholas J. Andersen, Elissa A. Boguslawski, Agni S. Naidu, Christopher Szot, Jennifer L. Bromberg-White, Kara Kits, Cynthia Y. Kuk, Laura E. Holton, Bradley St. Croix, Christopher M. Chambers & Nicholas S. Duesbery
Anthrax toxin receptor 1/tumor endothelial marker 8 (Antxr1 or TEM8) is up-regulated in tumor vasculature and serves as a receptor for anthrax toxin, but its physiologic function is unclear. The objective of this study was to evaluate the role of Antxr1 in arteriogenesis. The role of Antxr1 in arteriogenesis was tested by measuring gene expression and immunohistochemistry in a mouse model of hindlimb ischemia using wild-type and ANTXR1-/- mice. Additional tests were performed by measuring...

Registration Year

  • 2015
    2

Resource Types

  • Dataset
    2

Affiliations

  • National Cancer Institute
    2
  • Saint Petersburg State University
    1
  • Pontifical Catholic University of Rio Grande do Sul
    1
  • University of Chile
    1
  • HudsonAlpha Institute for Biotechnology
    1