1,495 Works

Characterisation of chamber-specific fibroblasts from adult human heart and investigation of their potential contribution to the function of engineered heart tissue

Amina Khalil
Research in the past 15 years has shown that the adult heart, including human, contains cardiac fibroblasts exhibiting regenerative capacity. Little is known about the precise characteristics, properties, and differentiation potential of endogenous cardiac fibroblasts (CF) in the four cardiac chambers of the human heart, and how these are affected by the disease process. The fibroblast population in the heart is being redefined from an inert scar-forming cell type into one, which has an active...

Development of quantitative tools and empirical approaches to aid the control and elimination of schistosomiasis in sub-Saharan Africa: from field to policy

Arminder Kaur Deol
Schistosomiasis is a debilitating chronic parasitic disease that occurs in the poorest regions of the world, predominantly in sub-Saharan Africa (SSA), infecting around 240 million individuals. With the vision of “a world free of schistosomiasis”, the WHO and its partners have pledged to meet the ambitious goals of controlling morbidity (i.e. as currently defined, to decrease the prevalence of heavy infection intensity to less than 5% across all sentinel sites) of schistosomiasis by 2020 (in...

Assessing the impacts of environmental change on British pollinators (Syrphidae) using next generation sequencing techniques

Hannah Norman
British pollinating insects are vital for their contribution to crop yields as well as maintenance of semi-natural environments across the UK. The Syrphidae family are highly diverse and thought to be an important pollinating group. In order to understand the evolutionary relationships in this family, mitochondrial genomes were used to build the largest tree of the Syrphidae family to date. This tree was used to establish relative ages for divergences within the family, and to...

GAJXOH, Osmium

Henry Rzepa
Gaussian Calculation


Henry Rzepa
Gaussian Calculation

Joint probabilistic modelling of images and non-imaging covariates: a causal perspective

Daniel Coelho De Castro
Typical machine-learning tasks in imaging applications involve training a model to predict some target annotation (e.g. a class label) from an image. However, by neglecting valuable side-information that is often available in real-world settings, such models are vulnerable to confounding and may not generalise outside the lab environment. This thesis argues for the integration of causality into image analysis workflows, supported by the development of methodologies for jointly modelling images and non-imaging data, especially for...

Development of laser wakefield accelerators

Jan-Niclas Gruse
This thesis investigates theoretically and experimentally the wakefield generation, elec- tron acceleration and x-ray emission in laser driven plasma wakefield acceleration. In preparation for a multi-stage laser accelerator with multiple laser, one of the Astra-Gemini laser pulses at 100 TW was used to reflect off a plasma mirror, a 125 μm Kapton foil. Its reflectivity of up to 70% and beam quality was measured. The beam was then self-guide it through a gas cell in...

Performance and stability of nanostructured solid oxide fuel cell cermet electrodes

Jingyi Chen
Nickel-ceramic cermets are the most industrial relevant materials in solid oxide fuel cell (SOFC) anode and solid oxide electrolyser cell (SOEC) cathode today. Nano-structure engineering of the electrode provides the benefits of high electrochemical activity, but the electrode’s stability has been questionable. For commercial applications, SOFC cells should sustain good performance for 40,000 hours of high temperature operations. Nickel coarsening between 500 °C to 1000 °C for high temperature SOFCs leads to both a reduction...

Age of Information in Wireless Networks

Elif Tugce Ceran
Age of information (AoI) is a recently introduced metric that measures the freshness of status updates in monitoring applications and update-based systems. In this thesis, we investigate a wireless communication system in which the status updates of the underlying process of interest can be sampled at any time by the source node, and are transmitted to a destination node over an error-prone communication channel under transmission constraints. More specifically, we study the scheduling of sampling...

Characterising the bidirectional biomolecular interactions between the intestinal microbiota and host drug metabolism

Marine Patricia Magali Letertre
In pharmacological and toxicological studies, the aim is to improve drug efficacy while limiting toxicity. It is now recognised that the gut microbiota, which constitutes trillions of microbial cells and contains 150 time more genes that the human genome itself, can synthesise enzymes and metabolites that can influence the metabolism and toxicity of drugs in the host. Conversely, drugs themselves have also been identified to exert an impact on the community structure of the gut...

The ecology of chytrid lineages in Southern Africa

Pria Natalia Ghosh
The inter- and intraspecific diversity of microbial communities is known to be an important, but difficult to disentangle, factor in pathogen ecology. Conspecific or interspecific microbial interactions may result in competitive suppression, the evolution of pathogens to greater levels of virulence, environmental niche separation and coexistence or even result in the generation of novel recombinant pathogen genotypes. Batrachochytrium dendrobatidis (Bd), the causative agent of chytridiomycosis, is a uniquely destructive pathogen – it is the proximate...

Normal addition of acetylene to carbonyl group, G = -738.345029

Henry Rzepa
Gaussian Calculation


Feriel Rekhroukh
DFT Coordinates


Feriel Rekhroukh
Files for disposal

DFT coordinates

Feriel Rekhroukh
DFT coordinates

Alumination of Aryl Methyl Ethers: Switching Between sp2 and sp3 C–O Bond Functionalisation with Pd-Catalysis

Feriel Rekhroukh
The reaction of [{(ArNCMe)2CH}Al] (Ar = 2,6-di-iso-propylphenyl, 1) with aryl methyl ethers proceeded with alumination of the sp3 C–O bond by a presumed SN2 pathway. The selectivity of this reaction could be switched by inclusion of a catalyst. In the presence of [Pd(PCy3)2], chemoselective sp2 C–O bond functionalisation was observed. Kinetic isotope experiments and DFT calculations support a catalytic pathway involving the ligand-assisted oxidative addition of the sp2 C–O bond to a Pd---Al intermetallic complex....

Cope amination Ph IRC

Henry Rzepa
Gaussian Calculation

10.14469/hpc/4452 with amine added to carbonyl and PT (TI4 = -1083.041324) G = -1082.988629

Henry Rzepa
Gaussian Calculation

Spirit Checklist: Pharmacokinetics and Pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD)

Kathryn Maitland
TABS PKPD Standard Protocol items For intervention trials Checklist and Assessment schedule

The biology of mesenchymal stem cells and the utility of the cellular therapy in Multiple Sclerosis

Rehiana Ali
Multiple Sclerosis (MS) is the commonest cause of neurological disability in young adults and affects about 100 000 people in the UK. Although there are a number of licensed treatment options there remains an urgent need for neuro-protective and reparative strategies. Mesenchymal stem cells (MSCs) represent a heterogeneous population of cells found in a variety of connective tissue of which bone marrow-derived MSCs (BM-MSCs) are the best characterised. They are multi-potent cells which interact with...

Cope amination IRC

Henry Rzepa
Gaussian Calculation

Uncovering the link between mindfulness and sustainability: does mindfulness practice influence pro-environmental behaviours?

Ute Barbara Thiermann
Environmental scientists are struggling to design interventions that promote long lasting pro-environmental behaviour (PEB) change in individuals. While researchers have gathered compelling evidence that mindfulness practices positively affect personal well-being and pro-social behaviours, less is known about their relationship with PEB and if their widespread promotion could help promoting a more sustainable society. To contribute to this knowledge gap, this thesis investigates the following research question: Do mindfulness practitioners show higher levels of PEB and...

Targeting cell mechanics to inhibit metastatic mechanisms in pancreatic cancer

Alistair Rice
Metastasis, the spread of cancer cells from the primary tumour to a secondary site, requires biochemical and physical changes in cellular behaviour that are influenced by the tumour microenvironment. In pancreatic ductal adenocarcinoma (PDAC), excessive deposition of extracellular matrix proteins leading to increased stiffness characteristically occurs with cancer development, and the fibrotic stroma produced promotes tumourigenesis. Many cellular behaviours, for example the epithelial-mesenchymal transition (EMT), chemoresistance and invasiveness, are associated with increased levels of metastasis....

The distribution and characteristics of endogenous cardiac stem cells in the adult human heart

Sajiram Sarvananthan
The human myocardium harbours resident multi-potent cardiac progenitor cells (CPCs). We investigated the distribution, properties, differentiation potential and effect of LV function on CPCs in all chambers of the human heart. Biopsies from all chambers of the heart from the same patient with good (EF>45; n=5) and impaired LV function (EF<45; n=5) was analysed for c-kitpos and MDR-1pos CPCs. CPCs were isolated using MACS from ten patients (Good and Impaired LV, n=5/group) and was characterised....

Non-melanoma skin cancer in HIV infection: the role of human papillomavirus (HPV), individual immunogenotype (HLA ‘tissue type’) and Merkel cell polyomavirus (MCV)

Sacha Imran Goolamali
Non-melanoma skin cancer (NMSC) in HIV presents increasing problems e.g. incidence and morbidity. Ultraviolet light and human papillomavirus (HPV) are implicated in NMSC pathogenesis. In HIV, HPV is unequivocally involved in oral, anogenital and cervical squamous cell cancer (SCC) but its role in cutaneous SCC is unclear. Merkel cell polyomavirus (MCV), the cause of Merkel cell carcinoma, has not been investigated in NMSC in HIV. HLA immunogenotype characterises some dermatoses in HIV and associations with...

Registration Year

  • 2021

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  • Imperial College London
  • University of Cambridge
  • University of Exeter
  • Yale University
  • University of Leicester
  • University of Oxford
  • Estación Biológica de Doñana
  • Zhejiang University
  • University of Sussex
  • Johns Hopkins University