2,119 Works

Microstructure control in Ti-6246

Abigail Ackerman
Titanium alloys are widely used in gas turbine engines due to their high specific fatigue strength and ability to retain that strength up to temperatures in the range of 600°C. The alloy Ti-6Al-2Sn-4Zr-6Mo is used in the intermediate pressure compressor of the gas turbine engine, with a yield strength of around 1.1GPa. It has a microstructure of primary α laths within a β matrix. Between the primary α are much finer secondary α laths, creating...

On tilts of certain infinite level shimura varieties

Raffael Singer
Scholze's Siegel modular varieties $\cX_{\Gamma(p^\infty)}$ over a mixed characteristic perfectoid field are known to be perfectoid, yet their tilt remains somewhat elusive. We give two different methods to describe the tilt of spaces related to $\cX_{\Gamma(p^\infty)}$. The first, following an idea of Lurie, uses Drinfeld level structures to construct integral perfectoid models of infinite level Shimura curves. For the second method we show how to recover the Tate module of the universal family of abelian...

Efficient numerical modelling of the ultrasonic scattering from complex surface-breaking defects

Richard Phillips
Ultrasonic testing is routinely used in the nuclear power generation industry to assess the structural integrity of plant components. The regulatory nature of the industry means that ultrasonic inspection procedures require substantiation through experimental trials and semi-analytical simulation, which can be costly and time-consuming. Furthermore, due to the complex defect and component geometries that are commonly encountered in the industry, the generation of evidence that accurately represents real inspections can be challenging. Numerical modelling techniques...

The impact of human immunodeficiency virus-1 viral replicative capacity on infection of human cervical and rectal tissue explants ex vivo

Robert Kipyegon Langat
Characterization of the targets and kinetics of HIV infection within rectal and genital tissues is central to the assessment of novel prevention agents. The ex vivo models available are helpful for studying the initial stages of HIV‐1 infection, such as defining the primary HIV target cells and the factors that influence viral replication kinetics. Five HIV-1 clade C, 1 clade A and 1 clade A/D HIV-1 TF variants were isolated from IAVI Protocol C; a...

Elastic wave propagation in polycrystals

Ming Huang
Scattering occurs as elastic waves propagate through a random polycrystalline medium, exhibiting scattering-induced attenuation and velocity dispersion. These behaviours carry bulk information about microstructure and can therefore be used for microstructure characterisation. The purpose of this thesis is to gain knowledge about the behaviour of elastic waves in polycrystals in order to facilitate the characterisation of microstructure. This thesis contributes mainly in six aspects. First, a theoretical second-order approximation (SOA) model is developed to calculate...

Laser-based measurements of liquid-liquid mixing in horizontal pipes by transverse jets

Stuart Fraser Wright
Low pipeline velocities lead to stratification of liquid-liquid flows, resulting in phase slip where the in situ phase fractions differ from the input fractions. This prevents samples being obtained that are representative of these flow’s phase fractions, and thus, mixing is used to overcome stratification. This work investigates pipeline jet mixers, obtaining measurements for comparison with theory. A review of jets for mixing is presented which establishes that few studies have been published on liquid-liquid...

Effects of strain-rate and temperature on ductile damage and Fracture of metallic materials

Alexander Sancho Garcia
Ductile damage appears in metallic materials when they undergo sufficiently high plastic strain. It is caused by voids and produces degradation on the mechanical properties that eventually leads to the ductile fracture of the material. Like other properties, this behaviour is affected by the temperature and velocity of material deformation. This thesis investigates the effects that temperature and strain-rate have on ductile damage from an experimental and a modelling point of view, and explores innovative...

Multiple poles of the motivic zeta functions and the monodromy property

Luigi Lunardon
This thesis summarizes the results of my research during the years of my Ph. D. at Imperial College London. I was mostly concerned with questions involving the motivic zeta function for degenerating Calabi-Yau varieties and the monodromy properties for these degenerations; in parallel to this research, I had a small side project on simplicial contractions. The first question we investigated is related to the monodromy property for K3 surfaces which admits triple-points-free models. These Calabi-Yau...

Optimising synthetic biosynthesis of natural products by yeast genome engineering

Glen Oliver Gowers
The sustainable manufacturing of products is a cornerstone of society’s move towards a sustainable circular economy. Many industrial specialty and bulk chemicals that are normally derived from fossil fuel can also be made by engineering microbes with biosynthetic pathways. However, augmenting these microbes to reach industrial scale remains a bottleneck in adoption of biological manufacturing practices. Many new synthetic biology tools are being developed to address this bottleneck, leveraging the application of engineering principles to...

Fe(+)C trigonal, quad pinned back, quad

Henry Rzepa
Gaussian Calculation

Advances in network visualisation with an application to serious games

Jonathan Xiang-Sheng Zheng
This thesis concerns the visualisation of networks, through an in-depth study into the node-link diagram representation. Three subtopics are explored within this space. The first is the problem of node layout, where the optimisation of a popular energy function, known as stress, is improved through an algorithm known as stochastic gradient descent. The second is the method of edge bundling, where the idea of hierarchical edge bundling is explored in the absence of a known...

IDOZOQ, NBO = triple 1-105

Henry Rzepa
Gaussian Calculation

TISQOE Re-O(+)

Henry Rzepa
Gaussian Calculation

TISQOE Re-O(+)

Henry Rzepa
Gaussian Calculation

TISQOE W-O

Henry Rzepa
Gaussian Calculation

TISQOE Os-O(2+)

Henry Rzepa
Gaussian Calculation

MPV 1, b3lyp+GD3BJ/Def2-SVPP, SCRF=THF, reactant perfluoro-t-butyl, G = -2605.305170

Henry Rzepa
Gaussian Calculation

MPV 1, b3lyp+GD3BJ/3-21G, SCRF=THF, TS, G = -1548.478051 (epimer, G = -1548.473944, DG = 2.6)

Henry Rzepa
Gaussian Calculation

GAJXOH, Molybdenum

Henry Rzepa
Gaussian Calculation

MPV 2 + t-butyl, b3lyp+GD3BJ/Def2-SVPP, SCRF=THF, TS, G = -1712.698928 DG = 1.39

Henry Rzepa
Gaussian Calculation

MPV 1, b3lyp+GD3BJ/3-21G, SCRF=THF, TS, epimer, G = -1548.473944 IRC

Henry Rzepa
Gaussian Calculation

Cryo-EM studies of CMG translocation and cohesin loading

Carl Patrik Eickhoff
Before mitosis, the genome must be replicated in the parental cell and sister chromatids must be tethered to ensure accurate division of genes between daughter cells. Within the replisome, DNA unwinding is facilitated by the CMG helicase which contains a hexameric ATPase motor encircling the leading strand template. Intriguingly, the helicase polarity, the mechanism of translocation and how CMG- bound replisome factors such as Mcm10, the MCT complex and Polε affect the helicase has remained...

Strengthening human-robot symbiosis through multimodal sensing

Daniel Freer
As robotic technology has advanced throughout the ages, one of its primary functions has been to assist humans in completing difficult or dangerous tasks. Through the lens of outer space and healthcare, this thesis explores the possibility for a symbiotic relationship between humans and assistive robots by improving training protocols and with enhanced sensor data processing. This relationship is explored through several technologies: 1) a telerobotic simulator for training; 2) a wearable robotic sensing system...

Two new reality-based suggestions for molecules with a quadruple bond to carbon.

Henry Rzepa
Gaussian 16 calculations

Optimisation of gas field portfolios in the presence of uncertainty

Yaser Obiedallah Khojah
The study proposes an approach that incorporates both surface and subsurface parameters of gas projects in a portfolio model called the integrated stochastic gas economic optimisation model (ISGEM_opt). The model uses Monte Carlo simulation and genetic algorithms (GAs) to optimise the portfolio’s production strategy and satisfy contractual requirements under gas-in-place uncertainty. The production strategy is defined as the production rate and the starting time of each field in the portfolio. The optimised strategy demonstrates how...

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  • Imperial College London
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