2,720 Works

Comparison of open, laparoscopic, and robotic left colectomy for radical treatment of colon cancer: a retrospective analysis in a consecutive series of 211 patients

Zhixiang Huang, Taiyuan Li, Genghua Zhang, Zhen Zhou, Haoran Shi, Cheng Tang, Lingling Yang & Xiong Lei
Abstract Background Robotic surgery has been widely used in the radical treatment of colonic cancer. However, it is unclear what advantages the robotic approach offers over other approaches in left colectomy. This study aims to explore the advantage of robotic surgery in left colectomy by comparing open, laparoscopic, and robotic surgery. Methods A retrospective analysis was performed on the clinical data of patients with radical left colectomy for colon cancer who were admitted to the...

Comparison of open, laparoscopic, and robotic left colectomy for radical treatment of colon cancer: a retrospective analysis in a consecutive series of 211 patients

Zhixiang Huang, Taiyuan Li, Genghua Zhang, Zhen Zhou, Haoran Shi, Cheng Tang, Lingling Yang & Xiong Lei
Abstract Background Robotic surgery has been widely used in the radical treatment of colonic cancer. However, it is unclear what advantages the robotic approach offers over other approaches in left colectomy. This study aims to explore the advantage of robotic surgery in left colectomy by comparing open, laparoscopic, and robotic surgery. Methods A retrospective analysis was performed on the clinical data of patients with radical left colectomy for colon cancer who were admitted to the...

Additional file 2 of FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment—a pharmacokinetic-pharmacodynamic study

L. M. Paterson, D. Barker, S. Cro, P. Mozgunov, R. Phillips, C. Smith, L. Nahar, S. Paterson & A. R. Lingford-Hughes
Additional file 2. Exploratory objectives, hypotheses, outcomes and planned analyses.

Additional file 1 of Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Fabian Eichelmann, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote … & Vivian Viallon
Additional file 1. Supplementary material regarding (i) the definition of cancer cases for HCC, GBC, Adv.PrC and Loc.PrC; (ii) the definition and implementation of the data-shared lasso; (iii) the models used to derive point estimates and confidence intervals from the model selected by the data-shared lasso; and (iv) the univariate analysis conducted for comparison.

Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Fabian Eichelmann, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote … & Vivian Viallon
Abstract Background Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations. Methods We analysed targeted metabolomics data available for 5828 matched case-control pairs from cancer-specific case-control studies on breast, colorectal, endometrial, gallbladder, kidney, localized and advanced prostate cancer, and hepatocellular carcinoma nested...

Additional file 2 of Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Fabian Eichelmann, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote … & Vivian Viallon
Additional file 2: Supplementary tables and figures. Figure S1. Pearson correlation between the 117 original metabolites. Figure S2. Sensitivity analyses of mutually adjusted ORs for the overall associations and cancer type-specific deviations. Figure S3. Sensitivity analysis of mutually adjusted ORs for the overall associations and cancer type-specific deviations with or without excluding hormone users. Figure S4. p-values of tests for departure from linearity and effect modification by BMI. Figure S5. ORs for the overall associations...

Oral arsenic and retinoic acid for high-risk acute promyelocytic leukemia

Ya-Fang Ma, Ying Lu, Qian Wu, Yin-Jun Lou, Min Yang, Jie-Yu Xu, Cai-Hong Sun, Li-Ping Mao, Gai-Xiang Xu, Li Li, Jian Huang, Huai-Yu Wang, Li-Jiang Lou, Hai-Tao Meng, Jie-Jing Qian, Wen-Juan Yu, Ju-Ying Wei, Zhen-Yu Li, Xue-Lu Zhu, Xiao-Yan Yan, Su-Ning Chen, Jie Jin & Hong-Hu Zhu
Abstract Acute promyelocytic leukemia (APL) has become curable over 95% patients under a complete chemo-free treatment with all-trans retinoic acid (ATRA) and arsenic trioxide in low-risk patients. Minimizing chemotherapy has proven feasible in high-risk patients. We evaluated oral arsenic and ATRA without chemotherapy as an outpatient consolidation therapy and no maintenance for high-risk APL. We conducted a multicenter, single-arm, phase 2 study with consolidation phases. The consolidation therapy included Realgar–Indigo naturalis formula (60 mg/kg daily...

Cov2clusters: genomic clustering of SARS-CoV-2 sequences

Benjamin Sobkowiak, Kimia Kamelian, James E. A. Zlosnik, John Tyson, Anders Gonçalves da Silva, Linda M. N. Hoang, Natalie Prystajecky & Caroline Colijn
Abstract Background The COVID-19 pandemic remains a global public health concern. Advances in sequencing technologies has allowed for high numbers of SARS-CoV-2 whole genome sequence (WGS) data and rapid sharing of sequences through global repositories to enable almost real-time genomic analysis of the pathogen. WGS data has been used previously to group genetically similar viral pathogens to reveal evidence of transmission, including methods that identify distinct clusters on a phylogenetic tree. Identifying clusters of linked...

Additional file 3 of Cov2clusters: genomic clustering of SARS-CoV-2 sequences

Benjamin Sobkowiak, Kimia Kamelian, James E. A. Zlosnik, John Tyson, Anders Gonçalves da Silva, Linda M. N. Hoang, Natalie Prystajecky & Caroline Colijn
Additional file 3: Supplementary figure S3. The pairwise probability of linking two sequences by SNP distance and difference in collection date using the selected beta coefficients used in this study.

Additional file 4 of Cov2clusters: genomic clustering of SARS-CoV-2 sequences

Benjamin Sobkowiak, Kimia Kamelian, James E. A. Zlosnik, John Tyson, Anders Gonçalves da Silva, Linda M. N. Hoang, Natalie Prystajecky & Caroline Colijn
Additional file 4: Supplementary Table S1. The clustering results from the tested methods for SARS-CoV-2 sequences found in epidemiologically supported clusters isolated in British Columbia, Canada.

Targeted delivery and ROS-responsive release of Resolvin D1 by platelet chimeric liposome ameliorates myocardial ischemia–reperfusion injury

Xueyi Weng, Haipeng Tan, Zheyong Huang, Jing Chen, Ning Zhang, Qiaozi Wang, Qiyu Li, Jinfeng Gao, Dili Sun, Wusiman Yakufu, Zhengmin Wang, Weiyan Li, Guangrui Zhu, Zhiqing Pang, Yanan Song, Juying Qian & Junbo Ge
Abstract Resolvin D1 (RvD1) has been shown to provide effective protection against ischemia–reperfusion injury in multiple vital organs such as the heart, brain, kidney. However, the clinical translational potential of systemic administration of RvD1 in the treatment of ischemia–reperfusion injury is greatly limited due to biological instability and lack of targeting ability. Combining the natural inflammatory response and reactive oxygen species (ROS) overproduction after reperfusion injury, we developed a platelet-bionic, ROS-responsive RvD1 delivery platform. The...

dibromo-bis(dimethylmethylene) atropisomerism in polysiphenol, TS, G = -6140.547035

Henry Rzepa
Gaussian 16 (C01) calculation

Understanding the hand: robotics, virtual reality and the neuroscience of control

Charalambos Konnaris
Our primary interaction with the world is through the spontaneous generation of movement. In particular, the hand is a critical tool allowing humans to perform a myriad of dexterous manipulations. The brain's ability to control and coordinate movement across the multiple joints of the hand seems effortless and it remains unrivalled by any other artificial system when confronted with such a high dimensional-structure. Thus, replicating the naturalistic control functionality in a prosthetic hand poses a...

Interleukins 8 and 10 potentiate the genotoxicity of dietary carcinogens in colorectal cells

Abdullah Alsaleh
Colorectal cancer (CRC) accounts for more than 9% of all of cancer, therefore, it is considered as one of the major contributors to mortality worldwide. Lifestyle factors such as smoking, diet, alcohol, physical inactivity are known to contribute to the incidence of CRC. Cooking of meats at high temperatures cause a creation of browned surface, which leads to the formation of dietary carcinogens that have been reported to be associated with the occurrence of CRC....

Oxetane to lactone conversion, CF3, wB97XD/Def2-TZVPP, IRC

Henry Rzepa
Gaussian 16 (C01) calculation

Integrated information theory in complex neural systems

Pedro Antonio Martinez Mediano
This thesis concerns Integrated Information Theory (IIT), a branch of information theory aimed at providing a fundamental theory of consciousness. At its core, lie two powerful intuitions: • That a system that is somehow more than the sum of its parts has non-zero integrated information, Φ; and • That a system with non-zero integrated information is conscious. The audacity of IIT’s claims about consciousness has (understandably) sparked vigorous criticism, and experimental evidence for IIT as...

Value recovery from Waste Electrical and Electronic Equipment (WEEE): A potential opportunity towards a circular economy for end-of-life Mobile Phones

Moises Ulises Andreas Gomez Soto
Waste electrical and electronic equipment (WEEE) is one of the fastest growing solid waste streams worldwide and, if not treated properly, presents serious health and environmental issues as well as extensive loss of strategic metals. The dramatic increase in the consumption of raw materials over recent decades to meet consumer demand has led to an imbalance in supply and demand, and a potential threat to the continued supply of critical metals. WEEE is a resource-rich...

Oxetane to lactone conversion, wB97XD/Def2-TZVPP TS G = -420.863643, IRC

Henry Rzepa
Gaussian 16 (C01) calculation. To view IRC files, download and drop into a browser window

Early growth in cystic fibrosis and the pathways to lung function

Amy Meryl Macdougall
Cystic Fibrosis (CF) is an inherited disease multi-organ disease that predominately affects the lungs. A key feature of the disease is progressive lung disease, and the main cause of death is respiratory failure. Preservation of good lung function through childhood is a major goal of treatment. Research has shown that somatic growth, as indicated by weight and height, in early life is associated with later lung function, but much of this research has not made...

Evaluation of superplastic deformation mechanism for near-α TA15 Titanium Alloy: Microstructure Evolution and Constitutive Modelling

Tabassam Yasmeen
TA15 (Ti–6Al–2Zr–1Mo–1V) is a type of near-α titanium alloy. It is famous for its application in the aerospace industry because of its high strength to mass ratio, high weldability, superior creep, and excellent creep resistance at high temperatures up to 550 °C. However, TA15 is challenging to be deformed and processed due to its low plasticity and narrow processing window. Hence, to exploit the superplastic deformation behaviour of TA15 in an effective manner, more fundamental...

Cavitation in blast induced traumatic brain injury: the occurrence, mechanism, threshold and implication

Xiancheng Yu
Blast induced traumatic brain injury (BTBI) has been a prevalent injury in recent conflicts, due to the vast use of improvised explosive devices. However, the mechanisms for BTBI remain unclear, particularly those linked to the primary blast waves. Recent neuropathological analysis have shown damage in the brain tissue close to the cerebrospinal fluid (CSF) in blast compared with non-blast TBI cases. CSF cavitation is a potential mechanism for this interface injury. This project aims to...

Rappe, TS1, cyclopropyl ring closure, trans, Ph, Def2-TZVPP, G = -5570.845733 IRC

Henry Rzepa
Gaussian 16 (C01) calculation

Registration Year

  • 2022
    2,720

Resource Types

  • Text
    1,505
  • Dataset
    1,028
  • Collection
    167
  • Image
    12
  • Report
    4
  • Audiovisual
    3
  • Model
    1

Affiliations

  • Imperial College London
    2,719
  • Fudan University
    44
  • Zhejiang University
    41
  • University of Oxford
    40
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    38
  • Harvard University
    37
  • Johns Hopkins University
    33
  • Southern Medical University
    32
  • Capital Medical University
    27
  • George Institute for Global Health
    26