2,724 Works

Additional file 1 of Randomized controlled trials in de-implementation research: a systematic scoping review

Aleksi J. Raudasoja, Petra Falkenbach, Robin W. M. Vernooij, Jussi M. J. Mustonen, Arnav Agarwal, Yoshitaka Aoki, Marco H. Blanker, Rufus Cartwright, Herney A. Garcia-Perdomo, Tuomas P. Kilpeläinen, Olli Lainiala, Tiina Lamberg, Olli P. O. Nevalainen, Eero Raittio, Patrick O. Richard, Philippe D. Violette, Jorma Komulainen, Raija Sipilä & Kari A. O. Tikkinen
Additional file 1: eFigure1. Flow diagram. eFigure 2. Published studies per medical content area. eFigure 3. Risk of bias per question. eFigure 4. Risk of bias inside intervention categories. eFigure 5. Intervention components in single-component interventions. eMethods 1. Search strategies. eMethods 2. Risk of Bias Tool for RCTs of complex interventions. eMethods 3. Refined version of intervention taxonomy for de-implementation interventions. eMethods 4. Rationale for refined intervention taxonomy. eMethods 5. Rationale for outcome hierarchy of...

Additional file 2 of Randomized controlled trials in de-implementation research: a systematic scoping review

Aleksi J. Raudasoja, Petra Falkenbach, Robin W. M. Vernooij, Jussi M. J. Mustonen, Arnav Agarwal, Yoshitaka Aoki, Marco H. Blanker, Rufus Cartwright, Herney A. Garcia-Perdomo, Tuomas P. Kilpeläinen, Olli Lainiala, Tiina Lamberg, Olli P. O. Nevalainen, Eero Raittio, Patrick O. Richard, Philippe D. Violette, Jorma Komulainen, Raija Sipilä & Kari A. O. Tikkinen
Additional file 2. Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist.

Should more patients be offered repair for mitral valve endocarditis? a single-centre 15-year experience

Clarissa Ng Yin Ling, David Bleetman, Soumik Pal, Hing Chi Kristie Leung, Habib Khan, Donald Whitaker, Olaf Wendler, Ranjit Deshpande & Max Baghai
Abstract Objective To describe the long-term outcomes of mitral valve repair (MVr) versus mitral valve replacement (MVR) in patients with native valve infective endocarditis (IE) at a centre with high-repair rates. Methods We conducted a retrospective single-centre cohort study. From 2005 to 2021, 183 patients with active or healed native valve IE were included. The primary outcome was long-term mortality. Patient status was last confirmed 31 March 2021. Secondary outcomes were post-operative MR, MV reoperation,...

What is the purpose of clinical trial monitoring?

Sharon B. Love, Victoria Yorke-Edwards, Elizabeth Ward, Rebecca Haydock, Katie Keen, Katie Biggs, Gosala Gopalakrishnan, Lucy Marsh, Lydia O’Sullivan, Lisa Fox, Estelle Payerne, Kerenza Hood & Garry Meakin
Abstract Background The sources of information on clinical trial monitoring do not give information in an accessible language and do not give detailed guidance. In order to enable communication and to build clinical trial monitoring tools on a strong easily communicated foundation, we identified the need to define monitoring in accessible language. Methods In a three-step process, the material from sources that describe clinical trial monitoring were synthesised into principles of monitoring. A poll regarding...

What is the purpose of clinical trial monitoring?

Sharon B. Love, Victoria Yorke-Edwards, Elizabeth Ward, Rebecca Haydock, Katie Keen, Katie Biggs, Gosala Gopalakrishnan, Lucy Marsh, Lydia O’Sullivan, Lisa Fox, Estelle Payerne, Kerenza Hood & Garry Meakin
Abstract Background The sources of information on clinical trial monitoring do not give information in an accessible language and do not give detailed guidance. In order to enable communication and to build clinical trial monitoring tools on a strong easily communicated foundation, we identified the need to define monitoring in accessible language. Methods In a three-step process, the material from sources that describe clinical trial monitoring were synthesised into principles of monitoring. A poll regarding...

Additional file 1 of What is the purpose of clinical trial monitoring?

Sharon B. Love, Victoria Yorke-Edwards, Elizabeth Ward, Rebecca Haydock, Katie Keen, Katie Biggs, Gosala Gopalakrishnan, Lucy Marsh, Lydia O’Sullivan, Lisa Fox, Estelle Payerne, Kerenza Hood & Garry Meakin
Additional file 1. Sources used for the paper.

In vivo function of the immunoreceptor NKG2D in intestinal inflammation and tumorigenesis

Sophie Curio
NKG2D is an activating receptor expressed on various immune cells. Engagement of NKG2D through its ligands, which are expressed mainly on transformed or stressed cells, typically leads to target cell death, thereby making it a potent player in anti-tumor immunity. We recently identified a pro-tumor role for NKG2D in the context of inflammation-driven cancer, where sustained expression of NKG2D and its ligands resulted in exacerbated disease in a model of hepatocellular carcinoma NKG2D has been...

One octafluorocubane, MP2, Def2-TZVPP 2E = -2,203.607698, 2H = -2,203.441504, 2G = -2,203.539794

Henry Rzepa
Gaussian 16 (C01) calculation

Improving outcomes in interstitial lung disease through the application of bioinformatics and systems biology

Arunon Sivananthan
Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are two distinct respiratory diseases whose features including pathogenesis and progression are not fully understood. However, both clinicians utilise changes in serial pulmonary function measurements to gain an insight into disease severity and control. More accurate prediction of disease progression would be beneficial, particularly for IPF given the variability in its clinical course as an unknown factor at the time of diagnosis. Home-based, real-time monitoring...

Investigating the trafficking, storage and release of lipids in pluripotent cells during mouse peri-implantation development

King Hang Tommy Mau
Embryonic development from pre-to-post-implantation involves critical transformations of the pluripotent lineage. Although the associated metabolic remodeling has often been regarded as survival adaptations to the implantation environment, emerging roles of metabolites played in cell state transition start to be recognized. Mammalian pre-implantation embryos are rich in lipids, which are not only essential structural building blocks, but also energy-yielding sub- strates and signaling molecules. Yet the mechanistic roles of the stored lipids in developmental progression are...

Glycerophospholipid oxidation and production of aldehydes in oesophageal adenocarcinoma

Pranav Harshad Patel
Oesophageal adenocarcinoma (OAC) has an unmet clinical need, with five year survival in the UK remaining at 15%. There has been little improvement with advances in surgical practice or systemic chemotherapeutic regimens. Early diagnosis holds the key to radical treatment, the clinical utility of breath testing has highlighted aldehydes as a potential early marker of cancer. The emerging field of lipidomics has identified variations in lipid composition between cancer and benign tissue. These observed changes...

Treatment With Dupilumab in Patients With Atopic Dermatitis: Systematic Review and Meta-Analysis

Fotios Koskeridis, Evangelos Evangelou, Evangelia E. Ntzani, Konstantinos Kostikas & Sophia Tsabouri
Atopic dermatitis (AD) is a type 2 chronic skin disorder associated with systemic and psychosocial comorbidities decreasing the quality of life for many patients. Dupilumab, a human monoclonal antibody that blocks interleukins IL-4 and IL-13, is a recently added systematic treatment option with an emerging evidence base. Here, we assessed the safety and efficacy of dupilumab in patients with AD. We conducted a systematic review and meta-analysis of placebo-controlled randomized clinical trials evaluating the safety...

(R )-Adamantyldeuteriomethanol with 589nm conf 1, b3lyp/Def2-TZVPP G = -505.205182

Henry Rzepa
Gaussian 16 (C01) calculation

(R )-Adamantyldeuteriomethanol with 589nm conf0 b3lyp/Def2-TZVPP, G = -505.205435

Henry Rzepa
Gaussian 16 (C01) calculation

4,5-difluoro-2,3,6,7-tetramethoxyphenanthrene, 7c, 1H

Henry Rzepa
NMRE data

1,2-bis(3-chloro-4,5-dimethoxyphenyl)ethane, 5b, 1H

Henry Rzepa
NMR Data

4,5-difluoro-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene, 6c, 13C, 19F

Henry Rzepa
NMR Data

4,5-dichloro-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene, 6b, 13C

Henry Rzepa
NMR Data

(E)-4,4'-(ethene-1,2-diyl)bis(2-allyl-6-methoxyphenol), 3d, 1H

Henry Rzepa
NMR Data

4,5-dichloro-9,10-dihydrophenanthrene-2,3,6,7-tetraol, 1b, 13C

Henry Rzepa
Raw spectrometer data and derived files, compound 1b

4,4'-(ethane-1,2-diyl)bis(2-bromo-6-methoxyphenol), 4a, 13C

Henry Rzepa
NMR Data

(E)-4,4'-(ethene-1,2-diyl)bis(2-chloro-6-methoxyphenol), 3b, 1H

Henry Rzepa
NMR Data

1,2-bis(3-fluoro-4,5-dimethoxyphenyl)ethane, 5c, 13C

Henry Rzepa
NMR Data

4,5-difluoro-9,10-dihydrophenanthrene-2,3,6,7-tetraol, 1c, 1H

Henry Rzepa
NMR data.

(E)-4,4'-(ethene-1,2-diyl)bis(2-chloro-6-methoxyphenol), 3b, 13C

Henry Rzepa
NMR Data

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