[Italiano]: Con l’espressione mira varietas lectionum si suole indicare, già a partire dalla filologia del Settecento, la straordinaria ricchezza di varianti nella tradizione di un testo antico; se da un lato l’aggettivo mirus tradisce un certo stupore e quasi un fastidio per l’eccessivo proliferare delle lezioni, dall’altro esso acquisisce il senso positivo dello straordinario guadagno di conoscenze che ne ricaviamo per la storia della tradizione e della trasmissione del testo. Lo studio della mira varietas...

A reasonable estimate of the resolution of a point cloud obtained by Structure-from-Motion (SfM) photogrammetry is mandatory in order to perform a correct analysis of the detected object. The knowledge of the expected resolution and of its limits allows one to establish, right from the measurement design stage, realistic hypothesis on the achievable degree of detail. This paper shows a case study designed for applications in the architectural field, where the distances involved generally range...

Abstract Background Hotspots of intraspecific genetic diversity represent invaluable resources for species to cope with environmental changes, and their identification is increasingly recognized as a major goal of conservation ecology research. However, even for iconic and endangered species, conservation strategies are often planned without thorough information on the geographic patterns of genetic variation. Here, we investigated the spatial patterns of genetic variation of the endangered Hermann’s tortoise Testudo hermanni in the Italian Peninsula by genotyping...

Additional file 2: Supplementary Table 1. Baseline features of the extension BODI cohort recruited for the analysis of the association between damage accrual and Heath related quality of life (n=147).

Additional file 1: Supplementary Note S1. Assembly of Neoechinorhynchus buttnerae draft genome. Supplementary Note S2. Assembly of Neoechinorhynchus agilis draft genome. Supplementary Table S1. Transcript abundance differences of candidates. Supplementary Table S2. Amino acid composition of candidate target proteins. Supplementary Table S3. Properties of target proteins. Supplementary Table S4. PFAM motifs of target proteins. Supplementary Table S5. 3D structure prediction of target proteins. Supplementary Table S6. Virtual ligand screening results. Supplementary Table S7. Bacterial genome...

Additional file 2: Supplementary Tables S3-S6.

Additional file 2: Supplementary Tables S3-S6.

Abstract Background Parents of children who have a congenital anomaly can experience significant worry about their child’s health. Access to clear, helpful, and trustworthy information can provide a valuable source of support. In this study the aim was to explore the information needs of parents/carers of children with congenital anomalies across Europe. Method A cross-sectional online survey was developed in nine languages to measure parents’ information needs, including: (1) the ‘helpfulness’/’trustworthiness’ of information received from...

Additional file 1: Supplementary Figure 1. Flow chart representing the patients’ recruiting process from the BODI validation cohort.

Additional file 1: Supplementary Figure 1. Flow chart representing the patients’ recruiting process from the BODI validation cohort.

The chamois Rupicapra spp. is the most abundant mountain ungulate of Europe and the Near East, where it occurs as two species, the Northern chamois R. rupicapra and the Southern chamois R. pyrenaica. Here, we provide a state-of-the-art overview of research trends and the most challenging issues in chamois research and conservation, focusing on taxonomy and systematics, genetics, life history, ecology and behavior, physiology and disease, management, and conservation. Research on Rupicapra has a longstanding...

Abstract Background Previous studies have demonstrated that purinergic receptors could be therapeutic targets to modulate the inflammatory response in multiple models of brain diseases. However, tools for the selective and efficient targeting of these receptors are lacking. The development of new P2X7-specific nanobodies (nbs) has enabled us to effectively block the P2X7 channel. Methods Temporary middle cerebral artery occlusion (tMCAO) in wild-type (wt) and P2X7 transgenic (tg) mice was used to model ischemic stroke. Adenosine...

Carbonate skeletal remains are altered and disintegrate at yearly to decadal scales in present-day shallow-marine environments with intense bioerosion and dissolution. Present-day brachiopod death assemblages are invariably characterized by poor preservation on continental shelves, and abundant articulated shells of brachiopods with well-preserved brachidia are thus not expected to be preserved if not rapidly buried. However, such preservation is paradoxically observed in shallow-water Paleozoic and Mesozoic brachiopod assemblages. Here, we show that a bathyal death assemblage...

Supplementary Material 1

Supplementary Material 1

Supplementary Material 2

Additional file 1: Supplemental Table 1. Patients with positive findings during radiological and cardiological follow up.

Abstract Background Parents of children who have a congenital anomaly can experience significant worry about their child’s health. Access to clear, helpful, and trustworthy information can provide a valuable source of support. In this study the aim was to explore the information needs of parents/carers of children with congenital anomalies across Europe. Method A cross-sectional online survey was developed in nine languages to measure parents’ information needs, including: (1) the ‘helpfulness’/’trustworthiness’ of information received from...

SfM (Structure from Motion) photogrammetry offers great versatility in survey and restitution operations. The most important feature that allows this technique to be applied to a wide range of observation distances is the resolution of the images intended both as the quantity and quality of the pixels that compose them. With the same digital camera, equipped with a good sensor (CMOS) and operating in good light conditions, it is possible to acquire images over large...

Abstract Background With the expansion of animal production, parasitic helminths are gaining increasing economic importance. However, application of several established deworming agents can harm treated hosts and environment due to their low specificity. Furthermore, the number of parasite strains showing resistance is growing, while hardly any new anthelminthics are being developed. Here, we present a bioinformatics workflow designed to reduce the time and cost in the development of new strategies against parasites. The workflow includes...

Additional file 1: Supplementary Note S1. Assembly of Neoechinorhynchus buttnerae draft genome. Supplementary Note S2. Assembly of Neoechinorhynchus agilis draft genome. Supplementary Table S1. Transcript abundance differences of candidates. Supplementary Table S2. Amino acid composition of candidate target proteins. Supplementary Table S3. Properties of target proteins. Supplementary Table S4. PFAM motifs of target proteins. Supplementary Table S5. 3D structure prediction of target proteins. Supplementary Table S6. Virtual ligand screening results. Supplementary Table S7. Bacterial genome...

Additional file 2: Supplementary Table 1. Baseline features of the extension BODI cohort recruited for the analysis of the association between damage accrual and Heath related quality of life (n=147).

Abstract Background This study aimed to investigate the trajectory of damage accrual, associated factors, and impact on health-related quality of life (HR-QoL) in a multicenter cohort of patients with Behçet’s syndrome (BS) over 2 years of follow-up. Methods Patients recruited in the BS Overall Damage Index (BODI) validation study were prospectively monitored for 2 years and assessed for damage accrual, defined as an increase ≥1 in the BODI score, and HR-QoL was evaluated by the...

Supplementary Material 2

Abstract Background Dyspnea is common after COVID-19 pneumonia and can be characterized by a defective CO2 diffusion (DLCO) despite normal pulmonary function tests (PFT). Nevertheless, DLCO impairment tends to normalize at 1 year, with no dyspnea regression. The altered regional distribution of ventilation and a dysfunction of the peripheral lung may characterize dyspnea at 1 year after COVID-19 pneumonia. We aimed at assessing the pattern of airway resistance and inflammation and the regional ventilation inhomogeneity...