2 Works

Data from: Within-host competition and drug resistance in the human malaria parasite Plasmodium falciparum

Mary Bushman, Lindsay Morton, Nancy Duah, Neils Quashie, Benjamin Abuaku, Kwadwo Koram, Pedro Dimbu, Mateusz Plucinski, Julie Gutman, Peter Lyaruu, Steven Kachur, Jacobus De Roode, Venkatachalam Udhayakumar, Jacobus C. De Roode, S. Patrick Kachur & Kwadwo A. Koram
Infections with the malaria parasite Plasmodium falciparum typically comprise multiple strains, especially in high-transmission areas where infectious mosquito bites occur frequently. However, little is known about the dynamics of mixed-strain infections, particularly whether strains sharing a host compete or grow independently. Competition between drug-sensitive and drug-resistant strains, if it occurs, could be a crucial determinant of the spread of resistance. We analyzed 1,341 P. falciparum infections in children from Angola, Ghana, and Tanzania and found...

Data from: 1970s and ‘Patient 0’ HIV-1 genomes illuminate early HIV/AIDS history in North America

Michael Worobey, Thomas D. Watts, Richard A. McKay, Marc A. Suchard, Timothy Granade, Dirk E. Teuwen, Beryl A. Koblin, Walid Heneine, Philippe Lemey & Harold W. Jaffe
The emergence of HIV-1 group M subtype B in North American men who have sex with men was a key turning point in the HIV/AIDS pandemic. Phylogenetic studies have suggested cryptic subtype B circulation in the United States (US) throughout the 1970s1, 2 and an even older presence in the Caribbean2. However, these temporal and geographical inferences, based upon partial HIV-1 genomes that postdate the recognition of AIDS in 1981, remain contentious3, 4 and the...

Registration Year

  • 2016
    2

Resource Types

  • Dataset
    2

Affiliations

  • Centers for Disease Control and Prevention
    2
  • University of Cambridge
    1
  • University of Ghana
    1
  • New York Blood Center
    1
  • Emory University
    1
  • University of Arizona
    1
  • University of California Los Angeles
    1
  • Ifakara Health Institute
    1
  • KU Leuven
    1