16 Works

Data from: The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways

Qingqing Zhu, Lu Song, Guangdun Peng, Na Sun, Jun Chen, Ting Zhang, Nengyin Sheng, Wei Tang, Cheng Qian, Yunbo Qiao, Ke Tang, Jing-Dong Han, Jinsong Li, Naihe Jing & Jing-Dong Jackie Han
The neural fate commitment of pluripotent stem cells requires the repression of extrinsic inhibitory signals and the activation of intrinsic positive transcription factors. However, how these two events are integrated to ensure appropriate neural conversion remains unclear. Here, we showed that Pou3f1 is essential for the neural differentiation of mouse embryonic stem cells (ESCs), specifically during the transition from epiblast stem cells (EpiSCs) to neural progenitor cells (NPCs). Chimeric analysis showed that Pou3f1 knockdown leads...

Immigration dynamics of tropical and subtropical Southeast Asian limestone karst floras

Xiao-Qian Li, Xiao-Guo Xiang, Qiang Zhang, Florian Jabbour, Rosa Del C. Ortiz, Andrey S. Erst, Zhen-Yu Li & Wei Wang
Ex situ origins and dispersal of taxa have played important roles in the assembly of island-like biodiversity hotspots. Insular limestone karsts in Southeast Asia are hotspots of biodiversity and endemism, but the immigration processes of their unique floras are still poorly known. Here, we used Gesneriaceae as a proxy to investigate immigration dynamics of tropical and subtropical Southeast Asian karst floras. We show that immigration into subtropical Southeast Asian karst floras first occurred in the...

Data from: Inhibition of Smurf2 translation by miR-322/503 protects from ischemia reperfusion injury by modulating EZH2/Akt/GSK3β signaling

Wei Dong, Fei Xie, Xuan-Ying Chen, Wei-Lin Huang, Yu-Zhen Zhang, Wen-Bo Luo, Jin Chen, Ming-Tuan Xie, Yu Liu & Xiao-Ping Peng
BACKGROUND: myocardial ischemia/reperfusion (I/R) is a common and lethal disease that threatens people's life worldwide. The underlying mechanisms are under intensive study and yet remain unclear. Here, we explored the function of miR-322/503 in myocardial I/R injury. METHODS: We used isolated rat perfused heart as an in vivo model and H9c2 cells subjected with the oxygen and glucose deprivation followed by reperfusion (OGD/R) as in vitro model to study myocardial I/R injury. TTC staining was...

Data from: Trophic dynamics of filter feeding bivalves in the Yangtze Estuarine Intertidal Marsh: stable isotope and fatty acid analyses

Sikai Wang, Binsong Jin, Haiming Qin, Qiang Sheng & Jihua Wu
Benthic bivalves are important links between primary production and consumers, and are essential intermediates in the flow of energy through estuarine systems. However, information on the diet of filter feeding bivalves in estuarine ecosystems is uncertain, as estuarine waters contain particulate matter from a range of sources and as bivalves are opportunistic feeders. We surveyed bivalves at different distances from the creek mouth at the Yangtze estuarine marsh in winter and summer, and analyzed trophic...

Distributed Feedback Lasers Based on MAPbBr3

Neda Pourdavoud, André Mayer, Maximilian Buchmüller, Kai Brinkmann, Tobias Häger, Ting Hu, Ralf Heiderhoff, Ivan Shutsko, Patrick Görrn, Yiwang Chen, Hella-Christin Scheer & Thomas Riedl
This is the peer reviewed version of the following article: Pourdavoud, N., Mayer, A., Buchmüller, M., Brinkmann, K., Häger, T., Hu, T. , Heiderhoff, R., Shutsko, I., Görrn, P., Chen, Y., Scheer, H.‐C., Riedl, T.: Distributed Feedback Lasers Based on MAPbBr3. Advanced Materials Technologies 2018, 3(4), 1700253 which has been published in final form at https://doi.org/10.1002/admt.201700253. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived...

Data from: Intercontinental genetic structure and gene flow in Dunlin (Calidris alpina), a potential vector of avian influenza

Mark P. Miller, Susan M. Haig, Thomas D. Mullins, Luzhang Ruan, Bruce Casler, Alexei Dondua, H. River Gates, J. Matthew Johnson, Steve Kendall, Pavel S. Tomkovich, Diane Tracy, Olga P. Valchuk & Richard B. Lanctot
Waterfowl (Anseriformes) and shorebirds (Charadriiformes) are the most common wild vectors of influenza A viruses. Due to their migratory behavior, some may transmit disease over long distances. Migratory connectivity studies can link breeding and nonbreeding grounds while illustrating potential interactions among populations that may spread diseases. We investigated Dunlin (Calidris alpina), a shorebird with a subspecies (C. a. arcticola) that migrates from nonbreeding areas endemic to avian influenza in eastern Asia to breeding grounds in...

Data from: Are habitat fragmentation, local adaptation and isolation by distance driving population divergence in wild rice Oryza rufipogon?

Yao Zhao, Klaas Vrieling, Hui Liao, Manqiu Xiao, Yongqing Zhu, Jun Rong, Wenju Zhang, Yuguo Wang, Ji Yang, Jiakuan Chen & Zhiping Song
Habitat fragmentation weakens the connection between populations and is accompanied with isolation by distance (IBD) and local adaptation (isolation by adaptation, IBA), both leading to genetic divergence between populations. To understand the evolutionary potential of a population and to formulate proper conservation strategies, information on the roles of IBD and IBA in driving population divergence is critical. The putative ancestor of Asian cultivated rice (Oryza sativa) is endangered in China due to habitat loss and...

Data from: Signatures of soft sweeps across the Dt1 locus underlying determinate growth habit in soybean [Glycine max (L.) Merr.]

LiMei Zhong, QiaoMei Yang, Xin Yan, Chao Yu, Liu Su, XiFeng Zhang & YouLin Zhu
Determinate growth habit is an agronomically important trait associated with domestication in soybean. Previous studies have demonstrated that the emergence of determinacy is correlated with artificial selection on four non-synonymous mutations in the Dt1 gene. To better understand the signatures of the soft sweeps across the Dt1 locus and track the origins of the determinate alleles, we examined patterns of nucleotide variation in Dt1 and the surrounding genomic region of approximately 800 kb. Four local,...

Data from: A multi-target brain-computer based on code modulated visual evoked potentials

Yonghui Lui, Qingguo Wei, Zongwu Lu & Yonghui Liu
The number of selectable targets is one of the main factors that affect the performance of a brain-computer interface (BCI). Most existing code modulated visual evoked potential (c-VEP) based BCIs use a single pseudorandom binary sequence and its circularly shifting sequences to modulate different stimulus targets, making the number of selectable targets limited by the length of modulation codes. This paper proposes a novel paradigm for c-VEP BCIs, which divides the stimulus targets into four...

Microsatellite genotypes of Camellia oleifera for GenoDive analysis

Xiangyan Cui, Shengyuan Qin, Xiaomao Huang, Xiaoqiang Yang & Jun Rong
Camellia oleifera, a hexaploid evergreen broadleaf shrub or small tree, is the dominant woody oilseed crop in China. Understanding the spatial pattern of genetic diversity in wild C. oleifera is essential for conservation and utilization of genetic resources. Six wild C. oleifera populations were sampled along a latitudinal gradient in subtropical evergreen broadleaf forests of Southern China. A new high-throughput sequencing-based microsatellite genotyping method was developed to resolve allele dosage uncertainty in hexaploid wild C....

Bayesian mimicry in the non-rewarding saprophytic orchid Danxiaorchis yangii

Boyun Yang
Bayesian mimicry, a type of deceptive pollination, is a complicated strategy used by non-rewarding plants to attract pollinators, but some hypotheses concerning this phenomenon have not been systematically verified. In order to show in detail a case of Bayesian mimicry on saprophytic orchid Danxiaorchis yangii in this study, we compared floral characteristics of Danxiaorchis yangii and Lysimachia alfredi as well as the pollination behavior of the insect Dufourea sp. towards the two species. Lysimachia alfredi...

Data from: Direct and indirect effects of nitrogen enrichment on soil organisms and carbon and nitrogen mineralization in a semi‐arid grassland

Dima Chen, Wen Xing, Zhichun Lan, Muhammad Saleem, Yunqiqige Wu, Shuijin Hu & Yongfei Bai
1. Semi-arid grasslands on the Mongolian Plateau are expected to experience high inputs of anthropogenic reactive nitrogen in this century. It remains unclear, however, how soil organisms and nutrient cycling are directly affected by N enrichment (i.e., without mediation by plant input to soil) vs. indirectly affected via changes in plant-related inputs to soils resulting from N enrichment. 2. To test the direct and indirect effects of N enrichment on soil organisms (bacteria, fungi, and...

Dr

QunGuang Jiang, Xiaorui Fu, Jinzhong Duanmu & Taiyuan Li
Colon adenocarcinoma (COAD) is the commonest colon cancer exhibiting high mortality. Due to the association with cancers progression, long noncoding RNAs (lncRNAs) become prognostic biomarkers. This study, using relevant clinic information and expression profiles of lncRNA originating in The Cancer Genome Atlas database, aims to construct a prognostic lncRNA signature to estimate the prognosis for patients. In the training cohort, prognosis related lncRNAs were selected from differently expressed lncRNAs by univariate Cox analysis. Furthermore, the...

A Tasquinomod-loaded dopamine-modified pH sensitive hydrogel is effective at inhibiting the proliferation of KRAS mutant lung cancer cells

Chuxi Zhang, Jun Xu, Chun Cheng, Jun Yang, Chenxi Li, Xia Liu & Yi Sang
Hydrogels can maintain a high local drug concentration during treatments and may be useful to local targeting diseased areas. We propose a pH sensitive hydrogel consisting of polyvinylpyrrolidone (PVP) and chitosan as a new treatment method for KRAS mutant lung cancer. Addition of dopamine improved the drug loading and release effects of this hydrogel. We demonstrate that Tasquinimod-loading of this dopamine-modified pH sensitive hydrogel is more effective than Tasquinimod alone for inhibiting the proliferation of...

Declining freshwater mussel diversity in the middle and lower reaches of the Xin River Basin: Threat and Conservation

Xiongjun Liu, Weiwei Sun, Ruiwen Wu, Weikai Wang, Yanli Wu, Shan Ouyang & Xiaoping Wu
Freshwater mussels provide important functions and services for aquatic ecosystems, but populations of many species have been extirpated. Information on biodiversity plays an important role in the conservation and management of freshwater mussels. The Xin River Basin is a biodiversity hotspot for freshwater mussels in China, with more than 43 species known, but populations of which are decreasing. Here, we quantify the diversity of freshwater mussels in the middle and lower reaches of the Xin...

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