5 Works

Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Kaare M. Gautvik, Ole K. Olstad, Ulrika Raue, Vigdis T. Gautvik, Karl J. Kvernevik, Tor P. Utheim, Solveig Ravnum, Camilla Kirkegaard, Håvard Wiig, Garan Jones, Luke C. Pilling, Scott Trappe, Truls Raastad & Sjur Reppe
Abstract Background A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of heavy-load exercise in older adults on diseases and functions as predicted by changes in muscle gene expression have been inadequately studied. Methods Thigh muscle global transcriptional activity (transcriptome) was analyzed in cohorts of older and younger adults before and after 12–13 weeks heavy-load strength exercise using Affymetrix microarrays....

Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Kaare M. Gautvik, Ole K. Olstad, Ulrika Raue, Vigdis T. Gautvik, Karl J. Kvernevik, Tor P. Utheim, Solveig Ravnum, Camilla Kirkegaard, Håvard Wiig, Garan Jones, Luke C. Pilling, Scott Trappe, Truls Raastad & Sjur Reppe
Abstract Background A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of heavy-load exercise in older adults on diseases and functions as predicted by changes in muscle gene expression have been inadequately studied. Methods Thigh muscle global transcriptional activity (transcriptome) was analyzed in cohorts of older and younger adults before and after 12–13 weeks heavy-load strength exercise using Affymetrix microarrays....

Additional file 1 of Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Kaare M. Gautvik, Ole K. Olstad, Ulrika Raue, Vigdis T. Gautvik, Karl J. Kvernevik, Tor P. Utheim, Solveig Ravnum, Camilla Kirkegaard, Håvard Wiig, Garan Jones, Luke C. Pilling, Scott Trappe, Truls Raastad & Sjur Reppe
Addiitional file 1: Figure S1. Comparison of transcript signal levels between os ilium–associated muscle and thigh muscle. Figure S2. Genes within the Diseases and Function category Vasculogenesis with increased (red) or reduced (green) expression end vs start of the training period in elderly as compared to young. Table S1. Common annotated genes changed in elderly in both Oslo and BSU cohorts at Q-value<0.1.

Sådan har Kasper Hjulmands moderne ledelsesstil styrket landsholdets og nationens fællesskab

Allan Bennich Grønkjær

Additional file 1 of Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Kaare M. Gautvik, Ole K. Olstad, Ulrika Raue, Vigdis T. Gautvik, Karl J. Kvernevik, Tor P. Utheim, Solveig Ravnum, Camilla Kirkegaard, Håvard Wiig, Garan Jones, Luke C. Pilling, Scott Trappe, Truls Raastad & Sjur Reppe
Addiitional file 1: Figure S1. Comparison of transcript signal levels between os ilium–associated muscle and thigh muscle. Figure S2. Genes within the Diseases and Function category Vasculogenesis with increased (red) or reduced (green) expression end vs start of the training period in elderly as compared to young. Table S1. Common annotated genes changed in elderly in both Oslo and BSU cohorts at Q-value<0.1.

Registration Year

  • 2022
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  • 2021
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Affiliations

  • Norwegian School of Sport Sciences
    5
  • Oslo University Hospital
    4
  • Ball State University
    4
  • Sørlandet Hospital Arendal
    4
  • University of Exeter
    4
  • Lovisenberg Diakonale Sykehus
    4
  • Stavanger University Hospital
    4