Long non-coding RNAs (lncRNAs) are crucial drivers in the progression of human diseases such as myocardial infarction (MI). However, the impact of lncRNA MCM3AP antisense RNA 1 (MCM3AP-AS1) on MI remains unknown. This research was determined to explore the effect of MCM3AP-AS1 modulating microRNA-24-3p (miR-24-3p) and eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) on MI. The rat MI models were constructed and, respectively, treated with altered MCM3AP-AS1, miR-24-3p or/and EIF4G2. Subsequently, the cardiac function,...

Long non-coding RNAs (lncRNAs) are crucial drivers in the progression of human diseases such as myocardial infarction (MI). However, the impact of lncRNA MCM3AP antisense RNA 1 (MCM3AP-AS1) on MI remains unknown. This research was determined to explore the effect of MCM3AP-AS1 modulating microRNA-24-3p (miR-24-3p) and eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) on MI. The rat MI models were constructed and, respectively, treated with altered MCM3AP-AS1, miR-24-3p or/and EIF4G2. Subsequently, the cardiac function,...

Abstract Background Loss-of-function (LOF) mutations of JAK1, a member of the JAK kinase family, were frequently observed in EC, indicating that JAK1 may act as a tumor suppressor, at least in EC. However, the mechanism of JAK1 mediated regulation of tumorigenesis remains poorly understood. Methods The genetic alterations of JAK1 in EC using latest sequencing dataset of EC deposited in TCGA database. The RNA-Seq dataset of EC and normal endometrial tissues from TCGA cohort was...

Supplemental material, sj-docx-1-jom-10.1177_01492063221126707 for How Shareholders Impact Stakeholder Interests: A Review and Map for Future Research by Mark R. DesJardine, Muhan Zhang, and Wei Shi in Journal of Management

ObjectiveThis study aimed to investigate clinical significance of Th1, Th2, Th17 and Tregs proportions in predicting and evaluating UC.MethodsA total of 101 UC patients diagnosed by the Department of Gastroenterology of the Shanxi Provincial People’s Hospital were recruited. This is a retrospective study. The proportions of Th1, Th2, Th17 and Tregs in the peripheral blood were detected by flow cytometry.ResultsThe proportions of Th1, Th2 and Th17 cell in UC patients were higher than healthy controls...

Research on how shareholders influence the interests of stakeholders has proliferated in recent years, at pace with the active debate on the merits of “stakeholder capitalism.” This research has sought to unpack: (1) the types of shareholders that affect stakeholder-relevant firm outcomes, (2) the mechanisms through which shareholders exert their influence on stakeholders’ interests, (3) the types of stakeholders that are influenced by shareholders, and (4) the factors that moderate the influence of shareholders on...

Additional file 5. Supplementary Tables.

Diabetic kidney diseases (DKD) were the leading cause of End-stage renal diseases worldwide. Albuminuria was a target for treatment in DKD and decreasing albuminuria was particularly important for improving its prognosis. However, there is still a lack of specific treatment for DKD. We conducted a prospective, crossover, open-label study to investigate the effect of amiloride in patients with DKD. Safety and efficacy were assessed by monitoring urine protein creatinine ratio(uPCR), urinary albumin creatinine ratio (uACR),...

BackgroundFew studies have examined the connections between psychological distress, meaning in life, internet gaming disorder (IGD), problematic smartphone use (PSU), and problematic social media use (PSMU).MethodsThe central and bridging nodes of IGD, PSMU, and PSU symptoms were investigated using network analysis in China among 742 adolescents (Mage = 15.39, SD = 1.68, range = 12–19; 53.23% female). The relationships between IGD, PSMU, and PSU and associated factors were investigated using a Directed Acyclic Graphs method.ResultsThe...

Supplemental material, sj-docx-1-jom-10.1177_01492063221126707 for How Shareholders Impact Stakeholder Interests: A Review and Map for Future Research by Mark R. DesJardine, Muhan Zhang, and Wei Shi in Journal of Management

Diabetic kidney diseases (DKD) were the leading cause of End-stage renal diseases worldwide. Albuminuria was a target for treatment in DKD and decreasing albuminuria was particularly important for improving its prognosis. However, there is still a lack of specific treatment for DKD. We conducted a prospective, crossover, open-label study to investigate the effect of amiloride in patients with DKD. Safety and efficacy were assessed by monitoring urine protein creatinine ratio(uPCR), urinary albumin creatinine ratio (uACR),...

Additional file 2: Fig. S1. JAK1 overexpression suppresses EC cell growth and migration.

Additional file 3: Fig. S2. JAK1 knockdown elevates the expression of HIF downstream genes in SPEC-2 cells.

Additional file 4: Fig. S3. JAK1 overexpression downregulates the expression of HIF downstream genes in Ishikawa cells.

ObjectiveThis study aimed to investigate clinical significance of Th1, Th2, Th17 and Tregs proportions in predicting and evaluating UC.MethodsA total of 101 UC patients diagnosed by the Department of Gastroenterology of the Shanxi Provincial People’s Hospital were recruited. This is a retrospective study. The proportions of Th1, Th2, Th17 and Tregs in the peripheral blood were detected by flow cytometry.ResultsThe proportions of Th1, Th2 and Th17 cell in UC patients were higher than healthy controls...

Direct exposure to natural disasters is associated with increased mental disorders. Help-seeking behaviour among Chinese adults is low and the barriers and facilitators of help-seeking among Chinese adults exposed to natural disasters is understudied. Using a person-centred approach, this study describes help-seeking preferences and their correlates in a sample of Chinese college students after experiencing Typhoon Hato, the strongest storm to affect Macao, China in the past 50 years. The baseline sample was collected one...

Swarms of earthquakes during shale gas exploitation in the Changning area of the Sichuan Basin indicate that hydraulic fracturing induces seismicity both within the target reservoir formation but also to depths of several kilometers below the horizontal well. These remote earthquakes are possibly triggered by total stress perturbations resulting from the hydraulic fracturing. We use a dislocation-based analytical model to simulate multistage hydraulic fracturing of three horizontal wells at a single well pad to explore...

Female pelvic organ prolapse (POP) is a common condition, which has a high recurrence rate after reconstructive surgery, and the risk factors for POP recurrence are unclear. The aim of this study was to perform a meta-analysis to determine risk factors for POP recurrence. A thorough search of PubMed, Medline, EMBASE, Cochrane Central Register of Controlled Trials, and China Academic Journal Network Publishing Database was conducted for relevant publications until 29 October 2022, without language...

Supplemental material, sj-docx-1-dhj-10.1177_20552076231158036 for Network analysis of internet gaming disorder, problematic social media use, problematic smartphone use, psychological distress, and meaning in life among adolescents by Yumei Li, Wenlong Mu, Xuying Xie and Sylvia Y.C.L. Kwok in Digital Health

Supplemental material, sj-docx-1-dhj-10.1177_20552076231158036 for Network analysis of internet gaming disorder, problematic social media use, problematic smartphone use, psychological distress, and meaning in life among adolescents by Yumei Li, Wenlong Mu, Xuying Xie and Sylvia Y.C.L. Kwok in Digital Health

Supplemental Material for The significance of Th1,Th2,Th17and treg cells in the prediction and evaluation of ulcerative colitis by Yu Zhang, Wei Shi, GaiGai Cao, Jingru Li, Haijiao Wang, and Chonghua Hao in European Journal of Inflammation

Uniform slip rates along the main segments of strike slip faults and slip rates decreasing toward fault tips are widely observed along some intensively studied strike slip faults. The Laohushan fault, which is the central segment of the Haiyuan fault. By applying the 3D_Fault_Offsets code, we reevaluated the late Pleistocene slip rate of Laohushan fault. The estimated long-term slip rate of the Laohushan fault ranges from 2.57-5.09 mm/yr over the Miocene. By synthesizing previous slip...

Direct exposure to natural disasters is associated with increased mental disorders. Help-seeking behaviour among Chinese adults is low and the barriers and facilitators of help-seeking among Chinese adults exposed to natural disasters is understudied. Using a person-centred approach, this study describes help-seeking preferences and their correlates in a sample of Chinese college students after experiencing Typhoon Hato, the strongest storm to affect Macao, China in the past 50 years. The baseline sample was collected one...

The effect of low-grade metamorphic epidote on fault stability in granitoids at shallow depth is not well understood. We present structured laboratory observations of epidote and simulated Pohang granodiorite (an EGS site) gouges and mixtures to evaluate their frictional responses. The experiments were performed on powdered rock gouges at a constant confining pressure of 110 MPa, pore fluid pressures of 42 and 63 MPa, temperatures of 100-250℃ and epidote percentages in the range of 0-100...

Research on how shareholders influence the interests of stakeholders has proliferated in recent years, at pace with the active debate on the merits of “stakeholder capitalism.” This research has sought to unpack: (1) the types of shareholders that affect stakeholder-relevant firm outcomes, (2) the mechanisms through which shareholders exert their influence on stakeholders’ interests, (3) the types of stakeholders that are influenced by shareholders, and (4) the factors that moderate the influence of shareholders on...