7 Works

Convergence of carbapenem resistance and hypervirulence in a highly-transmissible ST11 clone of K. pneumoniae: An epidemiological, genomic and functional study

Ping Li, Qiqiang Liang, Wugao Liu, Beiwen Zheng, Lizhang Liu, Wei Wang, Zhijiang Xu, Man Huang & Youjun Feng
Co-occurrence of hypervirulence and KPC-2 carbapenem resistant phenotypes in a highly-transmissible ST11 clone ofKlebsiella pneumoniae has elicited deep concerns from public health stand point. To address this puzzle, we conducted a large-scale epidemiological, clinical and genomic study of K. pneumonia ST11 clones with both hypervirulence and carbapenem resistance in two tertiary hospitals in Zhejiang province. Most of the patients (15/23) were diagnosed with exclusively carbapenem-resistant K. pneumoniae (CRKP) infections. Ten death cases were reported, some...

Daidzein stimulates fatty acid-induced fat deposition in C2C12 myoblast cells via the G protein-coupled receptor 30 pathway

Chengjian Zhou, Ping Li, Meihong Han & Xuejun Gao
Fat deposition in skeletal muscle is an important aspect of improving meat quality. Isoflavones can promote animal anabolism, but whether and how they regulate muscle fat deposition remain largely unclear. In this study, we explored the role and corresponding molecular mechanism of one of the major isoflavones, daidzein, in fat deposition in C2C12 myoblast cells. In the absence of fatty acids (FAs), daidzein did not promote triglyceride synthesis and lipid droplet formation in cells but...

Opportunities and challenges in achieving co-management in marine protected areas in East Africa: a comparative case study

Jennifer K. O’Leary, Maurice Goodman, Arthur Tuda, Milali Machumu & Lindsey West
As marine ecosystems decline globally, scientists recommend increasing the coverage of marine protected areas (MPAs), but many are not effectively managed to deliver benefits. Community integration into MPA decision-making can increase management effectiveness by supporting behaviour change, but this poses implementation challenges. We examine differences in adaptive capacity, community engagement, and perceived MPA benefits using interviews and focal group meetings with two fishing communities from MPAs with different management strategies and geographic settings: a centrally...

Methane emission and sulfide levels increase in tropical seagrass sediments during temperature stress: a mesocosm experiment

Mats Björk, Rushingisha George, Martin Gullström, Thomas J. Lyimo & Matern S.P. Mtolera
Climate change-induced ocean warming is expected to greatly affect carbon dynamics and sequestration in vegetated shallow waters, especially in the upper subtidal where water temperatures may fluctuate considerably and can reach high levels at low tides. This might alter the greenhouse gas balance and significantly reduce the carbon sink potential of tropical seagrass meadows. In order to assess such consequences, we simulated temperature stress during low tide exposures by subjecting seagrass plants (Thalassia hemprichii) and...

Life history shifts in an exploited African fish following invasion by a castrating parasite

Nestory Peter Gabagambi, Arne Skorping, Mwita Chacha, Kwendwa Jonathan Kihedu & Adele Mennerat
Evolutionary theory predicts that infection by a parasite that reduces future host survival or fecundity should select for increased investment in current reproduction. In this study we use the cestode Ligula intestinalis and its intermediate fish host Engraulicypris sardella in Wissman Bay, Lake Nyasa (Tanzania) as a model system. Using data about infection of E. sardella fish hosts by L. intestinalis collected for a period of 10 years, we explored whether parasite infection affects the...

Daidzein stimulates fatty acid-induced fat deposition in C2C12 myoblast cells via the G protein-coupled receptor 30 pathway

Chengjian Zhou, Ping Li, Meihong Han & Xuejun Gao
Fat deposition in skeletal muscle is an important aspect of improving meat quality. Isoflavones can promote animal anabolism, but whether and how they regulate muscle fat deposition remain largely unclear. In this study, we explored the role and corresponding molecular mechanism of one of the major isoflavones, daidzein, in fat deposition in C2C12 myoblast cells. In the absence of fatty acids (FAs), daidzein did not promote triglyceride synthesis and lipid droplet formation in cells but...

Convergence of carbapenem resistance and hypervirulence in a highly-transmissible ST11 clone of K. pneumoniae: An epidemiological, genomic and functional study

Ping Li, Qiqiang Liang, Wugao Liu, Beiwen Zheng, Lizhang Liu, Wei Wang, Zhijiang Xu, Man Huang & Youjun Feng
Co-occurrence of hypervirulence and KPC-2 carbapenem resistant phenotypes in a highly-transmissible ST11 clone ofKlebsiella pneumoniae has elicited deep concerns from public health stand point. To address this puzzle, we conducted a large-scale epidemiological, clinical and genomic study of K. pneumonia ST11 clones with both hypervirulence and carbapenem resistance in two tertiary hospitals in Zhejiang province. Most of the patients (15/23) were diagnosed with exclusively carbapenem-resistant K. pneumoniae (CRKP) infections. Ten death cases were reported, some...

Registration Year

  • 2020
    7

Resource Types

  • Dataset
    4
  • Text
    2
  • Other
    1

Affiliations

  • University of Dar es Salaam
    7
  • The First Affiliated Hospital of Jinzhou Medical University
    4
  • Capital Medical University
    4
  • Xi'an Jiaotong University
    4
  • Guangdong Provincial Hospital of Traditional Chinese Medicine
    4
  • Zhongda Hospital Southeast University
    4
  • Nanjing University
    4
  • China Pharmaceutical University
    4
  • Beijing Institute of Technology
    4
  • Shanghai Jiao Tong University
    4