Label-free terahertz (THz) sensing with metasurfaces has attracted considerable attention in recent years, however, ultrahigh sensing sensitivity remains to be a huge challenge for practical applications. To improve the sensitivity of these devices, herein we have proposed an out-of-plane metasurface-assisted THz sensor consisting of periodically arranged bar-like meta-atoms. Benefiting from elaborate out-of-plane structures, the proposed THz sensor with high sensing sensitivity of 325 GHz/RIU can be easily fabricated via a simple three-step fabrication process. And,...

Additional file 1.

Additional file 2. The function of tucidinostat on tumor immunity. a Functional annotation clustering of genes regulated in tumor from CT26 tumor-bearing mice on day 10 post treatment with tucidinostat (25 mg/kg, gavage, daily, n=3) or DMSO as vehicle control (DMSO, n=3). b Representative cytograms (left) or summary histograms (right) for the cell surface PD-L1 expression in CT26 cells following different doses (2.5, 5, 7.5 μM) of vorinostat, tucidinostat, and TMP-195 treatment for 24h. c...

Additional file 3. Tucidinostat plus checkpoint blockade induces improved therapeutic efficacy. a Schema of the experiment. For bioluminescence imaging (BLI) in vivo, mouse 4T1-luc (5 × 105 cells) were engrafted into the flank of BALB/c mice. When established tumors were palpable 7 days after tumor cells inoculation, mice were treated with vehicle (DMSO, n=7), tucidinostat (25 mg/kg, gavage, daily, n=7), aPD-L1 (200 μg, i.p. injection, once every 3 days, n=7), or combination (n=7). Tumors volume...

Additional file 5. Tucidinostat plus checkpoint blockade induces CCL5 secretion. a Mouse CT26 cells (5 × 105 cells) were engrafted into the flank of BALB/c mice. When established tumors were palpable 7 days after tumor cells inoculation, mice were treated with different doses (12.5, 25, 75 mg/kg, gavage, daily, n=5) of tucidinostat. The expression of CCL5 in peripheral blood serum from CT26 tumor-bearing mice on day 10 post treatment initiation. Mouse CT26 cells (5 ×...

Additional file 5: Figure S3. Literature screening flow chart.

Abstract Background Due to the rarity of PBL and the lack of large-scale studies, the prognostic value of IPI in PBL was controversial. Especially in the rituximab era, the ability of IPI to stratify prognosis in patients receiving immunochemotherapy was severely reduced. Then revised IPI (R-IPI) and National Comprehensive Cancer Network IPI (NCCN-IPI) were introduced. The present study aimed to evaluate the prognostic value of IPI and the other IPIs in patients with PBL in...

Additional file 7: Fig S6. Elimination of C3 from serum to detect the deposition of LSSL and MASP-1 on the surface of HeLa cells. (A) Quantitative analysis of proteins on the HeLa cells analyzed by Alexa-488 staining followed by flow cytometry. (B, C) The histogram shows the fluorescence intensity and cell proportions of the above flow cytometry results, respectively. The data are presented as the means ± SDs. (D) Western blotting analysis of depleted and...

Additional file 1: Figure S1. Correlation of mRNA expression level of IDO1 with protein expression of PD-L1 in TCGA LUAD tumors (A) and NSCLC cell lines (B).

Additional file 1. The effect of tucidinostat on cell proliferation, apoptosis and hepatonephric function. a Comparison of cell proliferation of 4T1, LLC, and CT26 cells treated with different doses (2.5, 5, 7.5 μM) of tucidinostat for 24 h by CCK-8 assay. b Comparison of cell apoptosis of 4T1, LLC, and CT26 cells treated with different doses of tucidinostat (2.5, 5, 7.5 μM) for 6 h by Annexin V-FITC/PI assay. c Mouse CT26 cells (5 ×...

Northeast Bioengineering Conference Poster 4/23/22

Additional file 2: Figure S2. A–B and E–F. H460 and H520 cells were treated with 4 μM celastrol, and the levels of intracellular ROS were determined by flow cytometry and fluorescence microscope. C–D and G–H. H460 and H520 cells were treated with different concentrations of celastrol (0, 1, 2, and 4 μM) for 2 h. NAC was used at a dose of 5 μM, either alone or as a1h pretreatment, and the levels of intracellular...

Additional file 2: Table S1. List of antibodies used in this study.

Abstract Background To assess the geometrical risk factors for meniscal injuries. We hypothesized that the narrowness of the intercondylar notch and the smaller tibial spine could increase the risk of meniscal injuries. Methods We retrospectively studied two hundred and seven patients examined for knee magnetic resonance images. Two experienced orthopedists evaluated the severity of meniscal injuries. The notch width, bicondylar notch width, notch width index, condyle width of the femur, tibial spine height, and intercondylar...

Additional file 2. Fig. S2: List of blood cytokines in C57BL/6J female mice treated with vehicle or 2.5, 5, or 10 mg/kg SI-2 twice a day for 7 days.

Abstract Background The tumor immune microenvironment (TIME) generated by cancer-infiltrating immune cells has a crucial role in promoting or suppressing breast cancer progression. However, whether the steroid receptor coactivator-3 (SRC-3) modulates TIME to progress breast cancer is unclear. Therefore, the present study evaluates whether SRC-3 generates a tumor-promoting TIME in breast tumors using a syngeneic immune-intact mouse model of breast cancer. Methods We employed E0771 and 4T1 breast cancer in immune-intact syngeneic female C57BL/6 and...

Additional file 2. Clinicopathological Data for 40 TNBC.

Additional file 3. Digital raw data.

Additional file 4. Western Blot original image.

Abstract Background Triple negative breast cancer (TNBC) is one of the most lethal breast cancer subtypes. Due to a lack of effective therapeutic targets, chemotherapy is still the main medical treatment for TNBC patients. Thus, it is important and necessary to find new therapeutic targets for TNBC. Recent genomic studies implicated the Hippo / Yap signal is over activated in TNBC, manifesting it plays a key role in TNBC carcinogenesis and cancer progression. RBCK1 was...

Additional file 2: Figure S1. The antimicrobial activity of the culture medium collected at various CAP biodegradation stages. Figure S2. Genomic characteristics of the seven isolated strains. Figure S3. The integrated analysis pipeline for multi-omics datasets. Figure S4. The KEGG enrichment analysis of DEGs and correlation analysis of DEGs with CAP as well as its metabolites. Figure S5. The HPLC-QTOF-MS chromatograms of main metabolites produced by isolated CAP-degrading strains including Sphingomonas sp. CL5.1, Caballeronia sp....

Additional file 3. The MS/MS spectra of CAP and its products determined by HPLC-QTOF-MS.

Additional file 3.

Additional file 4.

Abstract Background Increasing rates of childhood obesity worldwide are a serious threat to the health of school-aged children. Unhealthy behavioral habits are modifiable factors in the control of childhood obesity, and personal and family factors are key influencing factors of behavioral habits in school-aged children. This study assessed the relationship between overweight/obesity, energy balance-related behaviors (EBRB), and their influencing factors in school-aged children. Methods This cross-sectional survey included 4412 primary school-aged (10–12 years) students who...