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Epidemiological and interventional studies have been rarely conducted among those with positive interferon-γ release assay (IGRA) results and radiologically inactive tuberculosis (TB) lesions on chest radiograph. This study aimed to estimate the effectiveness and safety of a six-week twice-weekly regimen (rifapentine plus isoniazid) among this key population in rural China. First, chest digital radiography was conducted to screen individuals with inactive TB lesions. Then, the identified participants were further evaluated and eligible participants with IGRA-positive...

Supplemental material, sj-pdf-2-imr-10.1177_03000605221147434 for The inflammatory cytokine profiles and ocular biometric characteristics of primary angle-closure glaucoma by Hong-Bo Zeng, Jun-Di Jiang, Rong Li, Jian Li, Wen-Juan Zeng, Xiong-Kai Li, Bin Hu, Fei Zhou, Hai-Ying Yu, Jian-Guo Xie, Zhi-Neng Ning and Xian Wang in Journal of International Medical Research

In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24...

In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24...

Background:Physical activity (PA) is considered an important factor affecting academic achievement (AA). Different intensities of PA affect mental engagement (ME), which, in turn, affects AA. However, the role of ME in the relationship between PA and AA remains unclear.Objective:This study aimed to examine the mediating and/or moderating role of ME (i.e. cognitive flexibility [COGFLEX], metacognition [META] and competitiveness achievement motivation [COMPETE]) in the relationship between PA (both moderate- and vigorous-intensity activities) and AA.Method:Structural equation modelling...

Supplemental Material for A diffuse reflectance portable near infrared spectroscopy system for the determination of biuret content in urea fertilizer by Jing Liu, Shaohui Yu, Shupeng Hu, Ziyang Ling, Jiguang Gao, Binmei Liu, Lixiang Yu, Yang Yang, Ye Yang, Qi Wang, Xiaoyu Ni, Liping Zhao and Yuejin Wu in Journal of Near Infrared Spectroscopy

Although structural colors based on nanostructures have attracted many researchers’ attentions due to their superior durability and high resolution, most previous reports focused on the static and dynamic structural colors in reflection mode and few researchers focus on the static and dynamic transmission colors for high-saturation RGB models. Here, the hybrid Al-Si3N4 nanogratings with the top SiO2 capping layer and the bottom MgF2 layer that can switch full-hue and high-saturation transmitted structural colors on and...

Clean revised manuscript

Supplemental material, sj-docx-1-jaf-10.1177_0148558X221148626 for Measuring Disaggregation Quality by Ryan Casey, Feng Gao, Michael Kirschenheiter, Siyi Li and Shailendra Pandit in Journal of Accounting, Auditing & Finance

We construct a modified measure of disaggregation quality (MDQ) based on the disaggregation quality (DQ) measure from Chen et al. Both are parsimonious measures of disclosure quality in the annual report using the percentage of nonmissing financial statement items in Compustat. However, we take additional screening steps to minimize counting errors by resolving missing values due to GAAP changes over time and using a more comprehensive set of accounting equations from Casey et al. We...

Synthesis method, experimental data, calculation process, etc.

Optical waveguide amplifiers are essential devices in integrated optical systems. Their gain bandwidths directly determine the operating wavelength of optical circuits. Due to the difficulty of developing wideband gain media, it has been a challenge to fabricate devices with broadband amplification capability, resulting in few reports on multi-band polymer waveguide amplifiers. Here, a polymer waveguide amplifier is demonstrated, which achieves loss compensation covering the whole (S+C)-band by using NaYF4:Tm,Yb@NaYF4@NaYF4:Er nanoparticles-doped SU-8 as the gain medium....

Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning...

Thioredoxin interacting protein (TXNIP) is a potential drug target for type 2 diabetes mellitus (T2DM) treatment. A series of quinazoline derivatives were designed, synthesised, and evaluated to inhibit TXNIP expression and protect from palmitate (PA)-induced β cell injury. In vitro cell viability assay showed that compounds D-2 and C-1 could effectively protect β cell from PA-induced apoptosis, and subsequent results showed that these two compounds decreased TXNIP expression by accelerating its protein degradation. Mechanistically, compounds...

Thioredoxin interacting protein (TXNIP) is a potential drug target for type 2 diabetes mellitus (T2DM) treatment. A series of quinazoline derivatives were designed, synthesised, and evaluated to inhibit TXNIP expression and protect from palmitate (PA)-induced β cell injury. In vitro cell viability assay showed that compounds D-2 and C-1 could effectively protect β cell from PA-induced apoptosis, and subsequent results showed that these two compounds decreased TXNIP expression by accelerating its protein degradation. Mechanistically, compounds...

Supplemental material, sj-pdf-1-tct-10.1177_15330338231152350 for A Randomized Phase III Study of Anlotinib Versus Bevacizumab in Combination With CAPEOX as First-Line Therapy for RAS/BRAF Wild-Type Metastatic Colorectal Cancer: A Clinical Trial Protocol by Jinjie He, Yue Liu, Chengcheng Liu, Hanguang Hu, Lifeng Sun, Dong Xu, Jun Li, Junye Wang, Xiaobing Chen, Rongbo Lin, Yi Jiang, Yanqiao Zhang, Weisheng Zhang, Ying Cheng, Xiaohong Wu, Mingzhi Fang, Enxiao Li, Ye Xu, Ye Chen, Jiayi Li, Yanyan Cui, Zhanyu Pan,...

Supplemental material, sj-pdf-1-tct-10.1177_15330338231152350 for A Randomized Phase III Study of Anlotinib Versus Bevacizumab in Combination With CAPEOX as First-Line Therapy for RAS/BRAF Wild-Type Metastatic Colorectal Cancer: A Clinical Trial Protocol by Jinjie He, Yue Liu, Chengcheng Liu, Hanguang Hu, Lifeng Sun, Dong Xu, Jun Li, Junye Wang, Xiaobing Chen, Rongbo Lin, Yi Jiang, Yanqiao Zhang, Weisheng Zhang, Ying Cheng, Xiaohong Wu, Mingzhi Fang, Enxiao Li, Ye Xu, Ye Chen, Jiayi Li, Yanyan Cui, Zhanyu Pan,...

The spin Hall effect (SHE) of light has brought important applications, but the involved spin states only split in one direction. Here we employ an accurate three-dimensional model of light to show that the SHE generally exhibits a quadratic spin splitting, i.e., both vertical and horizontal splitting, in the presence of phase change of reflection. Further, we disclose that the two splittings are actually different from each other, and they origin respectively from the vertical...

The spin Hall effect (SHE) of light has brought important applications, but the involved spin states only split in one direction. Here we employ an accurate three-dimensional model of light to show that the SHE generally exhibits a quadratic spin splitting, i.e., both vertical and horizontal splitting, in the presence of phase change of reflection. Further, we disclose that the two splittings are actually different from each other, and they origin respectively from the vertical...

supplement 1

Introduction: Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the second and third trimesters. The disease's etiology and diagnostic criteria are currently unknown. Based on a sequence window to obtain all theoretical fragment ions (SWATH) proteomic approach, this study sought to identify potential proteins in placental tissue that may be involved in the pathogenesis of ICP and adverse fetal pregnancy outcomes. Methods: The postpartum placental tissue of pregnant women with ICP were chosen as the...

Clean revised manuscript

Supplementary Material 2

ABSTRACT This paper discusses the design of a safflower picking robot control system and focuses on a navigation control subsystem based on multisensor fusion. A navigation subsystem, an identification and positioning subsystem, a picking subsystem, and a levelling subsystem are designed. The hardware and software of the navigation subsystem are designed in detail, and a multisensor fusion positioning method based on extended Kalman fusion technology is proposed. The accuracy and stability levels of different combined...