We present estimates of the number of refugees expected to flee Ukraine and to which countries they are expected to migrate based on migration preferences data from the Gallup World Poll (GWP). This is important in terms of both immediate refugee assistance efforts and long-term integration policies. Our key finding is that as many as 12 million people may want to leave Ukraine permanently and that refugee policies in potential destination countries are likely to...

Additional file 12. Table S8: Performance of MP4 on Mycobacterium tuberculosis NITR203 proteins.

Additional file 3. Fig. S1: Mean decrease in accuracy of top 30 features selected through random forest algorithm.

Additional file 4. Table S3: Performances of random forest-based models at top features and different mtry values.

Additional file 8. Table S4: Blind set performance of best RF-based model.

Two new nor-triterpenoids ganodrenol A (1), B (2), and a new natural product ganodrenol C (3), along with three known nor-triterpenoids (4–6) were isolated from the fruiting bodies of Ganoderma lucidum. The chemical structures of these isolates were determined by 1 D and 2 D NMR, HRESIMS, and X-ray crystallography analysis. The inhibitory effects of isolated triterpenoids (1–6) against FAAH were evaluated by an in vitro assay, and compound 4 showed an inhibition rate of...

The popularity of relaxed clock Bayesian inference of clade origin timings has generated several recent publications with focal results considerably older than the fossils of the clades in question. Here we critically examine two such clades: the animals (with focus on the bilaterians); and the mammals (with focus on the placentals). Each example displays a set of characteristic pathologies which, although much commented on, are rarely corrected for. We conclude that in neither case does...

Abstract Background Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has shown potential for the treatment of mild-to-moderate Alzheimer’s disease (AD). However, there is little evidence of whether NBM-DBS can improve cognitive functioning in patients with advanced AD. In addition, the mechanisms underlying the modulation of brain networks remain unclear. This study was aimed to assess the cognitive function and the resting-state connectivity following NBM-DBS in patients with advanced AD. Methods Eight...

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221147363 for Cerebral blood flow regulates iron overload in the cerebral nuclei of hemodialysis patients with anemia by Huiying Wang, Chao Chai, Gemuer Wu, Jinping Li, Chenxi Zhao, Dingwei Fu, Shengtong Zhang, Huapeng Wang, Beini Wang, Jinxia Zhu, Wen Shen, Shuang Xia in Journal of Cerebral Blood Flow & Metabolism

Liposome surface coating has been studied to avoid the immunological responses caused by the complement system, and alternative materials to poly(ethylene glycol) (PEG) have been explored recently since the production of anti-PEG IgM antibodies has been found in humans. We previously reported a liposome coating with poly(2-methacryloyloxyethyl phosphorylcholine) (poly(MPC))-conjugated lipids (PMPC-lipids) and demonstrated its protective effect on blood protein interactions. Here, we attempted to modify the liposome surface by exogenously adding PMPC-lipids, which were spontaneously...

Liposome surface coating has been studied to avoid the immunological responses caused by the complement system, and alternative materials to poly(ethylene glycol) (PEG) have been explored recently since the production of anti-PEG IgM antibodies has been found in human. We previously reported a liposome coating with poly(2-methacryloyloxyethyl phosphorylcholine) (poly(MPC))-conjugated lipids (PMPC-lipids) and demonstrated its protective effect on blood protein interactions. Here, we attempted to modify the liposome surface by exogenously adding PMPC-lipids, which were spontaneously...

Additional file 1: Supplementary Methods. Table S1. Mappings of ICD-10 and ICD-9 codes to the phenotypes identified by MR-PheWAS at the nominal significance level (p<0.05). Table S2. Information on the FinnGen study and international consortia. Table S3. Search strategy in the PubMed database. TableS4. Characteristics of participants in the UK Biobank (N=339,197). Table S5. Outcomes included in the analyses and outcomes excluded due to power (N<200 cases). Table S6. Phenotypes associated with genetically predicted milk...

supplement 1

The establishment of structure activity relationship (SAR) for rakicidin derivatives is pretty vital to develop rakicidins as a new type of anti-cancer agents. Herein, two novel rakicidin derivatives, compounds B1-1 (1) and B1-2 (2), a cyclic depsipeptide and a chain lipopeptide, respectively, were isolated from culture broth of Micromonospora chalcea FIM-R160609, and their structures were elucidated clearly by extensive NMR and HR-ESI-MS analyses. Following, their cytotoxic activities were evaluated against HCT-8 and PANC-1 human cancer...

Additional file 1. The tables of the filtering parameters setting using Prinseq-lite software, primers and probes used to detect co-infection respiratory viruses, type analysis of common virus-related sequence viral in MP positive and MP negative (TTV has been removed). Table S1: The filtering parameters setting using Prinseq-lite software. Table S2: Primers and probes used to detect co-infection respiratory viruses. Table S3: Type analysis of common virus-related sequence viral in MP positive and MP negative (TTV...

Abstract Background The Accelerating Innovation for Mothers (AIM) project established a database of candidate medicines in research and development (R&D) between 2000 and 2021 for five pregnancy-related conditions, including pre-eclampsia. In parallel, we published target product profiles (TPPs) that describe optimal characteristics of medicines for use in preventing/treating pre-eclampsia. The study objective was to use systematic double screening and extraction to identify all candidate medicines being investigated for pre-eclampsia prevention/treatment and rank their potential based...

Additional file 12.

Additional file 1.

Additional file 5.

Additional file 2. Template for intervention description and replication (TIDieR) checklist.

Additional file 6.

Additional file 6.

Additional file 8.

Additional file 2: Supplementary Fig. 2. Significant difference in VAP-1 expression. There were significant differences in a) VAP-1 area % (NEC = 0,065 ± 0,035; controls = 0,11 ± 0,042, t(1,66) = 4.89, p < 0.001), b) VAP-1 mean (NEC = 80,74 ± 3,81; controls = 86,29 ± 6,06, t(1,66) = 4.65, p < 0.001), c) VAP-1 median (NEC = 76,44 ± 3,39; controls = 81,92 ± 6,09, t(1,66) = 4.77, p < 0.001), d)...

Additional file 3: Supplementary Fig. 3. Linear regression indicated a strong correlation between mean VAP-1 expression and VAP-1 area % for a) all included infants (R2 = 0.61, F(1, 66) = 101.4, p < 0.001, n = 68), b) NEC infants (R2 = 0.52, F(1, 40) = 43.69, p < 0.001, n = 42) and for c) control infants (R2 = 0.49, F(1, 24) = 22.88, p < 0.001, n = 26).