399 Works

Vascular adhesion protein-1 expression is reduced in the intestines of infants with necrotizing enterocolitis: an observational research study

Björn Andersson, Laszlo Markasz, Hamid Mobini-Far & Helene Engstrand Lilja
Abstract Background Necrotizing enterocolitis (NEC) is an inflammatory bowel disease in preterm neonates with high morbidity and mortality. The only treatment available is supportive with broad-spectrum antibiotics and gastrointestinal rest. Better understanding of the pathogenesis is crucial for the development of new therapies. Vascular adhesion protein-1 (VAP-1), expressed in human blood vessels and lymphatic, plays a crucial role in the pathogenesis of inflammatory diseases in adults. The aim of the study was to investigate the...

Additional file 1 of Genomic trajectories of a near-extinction event in the Chatham Island black robin

Johanna von Seth, Tom van der Valk, Edana Lord, Hanna Sigeman, Remi-André Olsen, Michael Knapp, Olga Kardailsky, Fiona Robertson, Marie Hale, Dave Houston, Euan Kennedy, Love Dalén, Karin Norén, Melanie Massaro, Bruce C. Robertson & Nicolas Dussex
Additional file 1.

Additional file 1 of Genomic trajectories of a near-extinction event in the Chatham Island black robin

Johanna von Seth, Tom van der Valk, Edana Lord, Hanna Sigeman, Remi-André Olsen, Michael Knapp, Olga Kardailsky, Fiona Robertson, Marie Hale, Dave Houston, Euan Kennedy, Love Dalén, Karin Norén, Melanie Massaro, Bruce C. Robertson & Nicolas Dussex
Additional file 1.

Additional file 2 of Genomic trajectories of a near-extinction event in the Chatham Island black robin

Johanna von Seth, Tom van der Valk, Edana Lord, Hanna Sigeman, Remi-André Olsen, Michael Knapp, Olga Kardailsky, Fiona Robertson, Marie Hale, Dave Houston, Euan Kennedy, Love Dalén, Karin Norén, Melanie Massaro, Bruce C. Robertson & Nicolas Dussex
Additional file 2.

Additional file 2 of Vascular adhesion protein-1 expression is reduced in the intestines of infants with necrotizing enterocolitis: an observational research study

Björn Andersson, Laszlo Markasz, Hamid Mobini-Far & Helene Engstrand Lilja
Additional file 2: Supplementary Fig. 2. Significant difference in VAP-1 expression. There were significant differences in a) VAP-1 area % (NEC = 0,065 ± 0,035; controls = 0,11 ± 0,042, t(1,66) = 4.89, p < 0.001), b) VAP-1 mean (NEC = 80,74 ± 3,81; controls = 86,29 ± 6,06, t(1,66) = 4.65, p < 0.001), c) VAP-1 median (NEC = 76,44 ± 3,39; controls = 81,92 ± 6,09, t(1,66) = 4.77, p < 0.001), d)...

Additional file 3 of Vascular adhesion protein-1 expression is reduced in the intestines of infants with necrotizing enterocolitis: an observational research study

Björn Andersson, Laszlo Markasz, Hamid Mobini-Far & Helene Engstrand Lilja
Additional file 3: Supplementary Fig. 3. Linear regression indicated a strong correlation between mean VAP-1 expression and VAP-1 area % for a) all included infants (R2 = 0.61, F(1, 66) = 101.4, p < 0.001, n = 68), b) NEC infants (R2 = 0.52, F(1, 40) = 43.69, p < 0.001, n = 42) and for c) control infants (R2 = 0.49, F(1, 24) = 22.88, p < 0.001, n = 26).

Electrocardiographic QTc as a Surrogate Measure of Cardiac Risk in Children, Adolescents, and Young Adults With Eating Disorders

Perry B. Dinardo, Ellen S. Rome, Ira B. Taub, Wei Liu, Kenneth Zahka & Peter F. Aziz
The study goal was to investigate electrocardiographic findings, including corrected QT interval (QTc), in patients aged 8 to 23 with eating disorders (EDs) at presentation, compared with an age-and sex-matched control population. We retrospectively reviewed 200 ED patients, and 200 controls. Blinded electrocardiograms (ECGs) were interpreted by an expert reader, and QT intervals corrected using the Bazett formula. Eating disorder patients were 89.5% female, with mean age 16.4 years and median percent median body mass...

Additional file 5 of MED12 mutation as a potential predictive biomarker for immune checkpoint inhibitors in pan-cancer

Yong Zhou, Yuan Tan, Qin Zhang, Qianqian Duan & Jun Chen
Additional file 5: Table S1. Detailed clinical information of the five WES cohorts and the MSKCC cohort.

MED12 mutation as a potential predictive biomarker for immune checkpoint inhibitors in pan-cancer

Yong Zhou, Yuan Tan, Qin Zhang, Qianqian Duan & Jun Chen
Abstract Immune checkpoint inhibitors (ICIs) therapy elicits admirable anti-tumor responses across many types of cancer. Growing evidence point to a link to Mediator complex subunit 12 (MED12) and DNA damage repair (DDR) and TGF-β signing, while the clinical data on the association of MED12 and ICIs response are lacking. In this study, clinical and whole-exome sequencing (WES) data from published studies were merged as a WES cohort to explore the association between MED12 mutation (MED12-Mut)...

Additional file 4 of MED12 mutation as a potential predictive biomarker for immune checkpoint inhibitors in pan-cancer

Yong Zhou, Yuan Tan, Qin Zhang, Qianqian Duan & Jun Chen
Additional file 4: Materials and methods

Memory training with the method of loci for children and adolescents with ADHD—A feasibility study

Vladislav Ruchkin, Marwin Wallonius, Emma Odekvist, Sharmeen Kim & Johan Isaksson
The aim of this study was to investigate if training with the memory technique Method of Loci (MoL) is feasible for children and adolescents with ADHD. Twelve children (aged 9–17 years) with ADHD participated. Training with MoL was done using a mobile application, memorizing a sequence of 20–80 pictures, intended to be carried out five times per week for 4 weeks. Feasibility was assessed with pre- and post-intervention ratings, and with interviews after the training....

Supportive care in pediatric acute myeloid leukemia:Expert-based recommendations of the NOPHO-DB-SHIP consortium

Nira Arad-Cohen, Bernward Zeller, Jonas Abrahamsson, Jose Maria Fernandez Navarro, Daniel Cheuk, Sauli Palmu, Vitor Costa, Barbara De Moerloose, Henrik Hasle, Kirsi Jahnukainen, Cornelis Jan Pronk, Ólafur Gísli Jónsson, Zhanna Kovalova, Birgitte Lausen, Monica Munthe-Kaas, Ulrika Noren-Nyström, Josefine Palle, Ramune Pasauliene, Kadri Saks & Gertjan JL Kaspers
Pediatric acute myeloid leukemia (AML) is the second most common type of pediatric leukemia. Patients with AML are at high risk for several complications such as infections, typhlitis, and acute and long-term cardiotoxicity. Despite this knowledge, there are no definite supportive care guidelines as to what the best approach is to manage or prevent these complications. The NOPHO-DB-SHIP (Nordic-Dutch-Belgian-Spain-Hong-Kong-Israel-Portugal) consortium, in preparation for a new trial in pediatric AML patients, had dedicated meetings for supportive...

T Pyxidis: Death by a Thousand Novae

Joseph Patterson, Arto Oksanen, Jonathan Kemp, Berto Monard, Robert Rea, Franz-Josef Hambsch, Jennie McCormick, Peter Nelson, William Allen, Thomas Krajci, Simon Lowther, Shawn Dvorak, Jordan Borgman, Thomas Richards, Gordon Myers, Caisey Harlingten & Greg Bolt
We report a 20-year campaign to track the 1.8 hour photometric wave in the recurrent nova T Pyxidis, using the global telescope network of the Center for Backyard Astrophysics. During 1996-2011, that wave was highly stable in amplitude and waveform, resembling the orbital wave commonly seen in supersoft binaries. The period, however, was found to increase on a timescale P/P-dot=3x10^5 years. This suggests a mass transfer rate in quiescence of ~10^-7 M_sol/yr, in substantial agreement...

Additional file 2 of Circular RNA circLOC101928570 suppresses systemic lupus erythematosus progression by targeting the miR-150-5p/c-myb axis

Xingwang Zhao, Rui Dong, Zhongwei Tang, Juan Wang, Chunyou Wang, Zhiqiang Song, Bing Ni, Longlong Zhang, Xiaochong He & Yi You
Additional file 2: Table S2. The sequences of the primers used for qRT–PCR.

Additional file 4 of Circular RNA circLOC101928570 suppresses systemic lupus erythematosus progression by targeting the miR-150-5p/c-myb axis

Xingwang Zhao, Rui Dong, Zhongwei Tang, Juan Wang, Chunyou Wang, Zhiqiang Song, Bing Ni, Longlong Zhang, Xiaochong He & Yi You
Additional file 4: Table S4. Identified and selected upregulated circRNAs and downregulated circRNAs (|fold change| >2, P < 0.01) between healthy controls and SLE patients by circRNA RNA-seq data.

Additional file 10 of MP4: a machine learning based classification tool for prediction and functional annotation of pathogenic proteins from metagenomic and genomic datasets

Ankit Gupta, Aditya S. Malwe, Gopal N. Srivastava, Parikshit Thoudam, Keshav Hibare & Vineet K. Sharma
Additional file 10. Table S6: Performance of MP4, MP3 and VirulentPred on real dataset-2.

Additional file 5 of Circular RNA circLOC101928570 suppresses systemic lupus erythematosus progression by targeting the miR-150-5p/c-myb axis

Xingwang Zhao, Rui Dong, Zhongwei Tang, Juan Wang, Chunyou Wang, Zhiqiang Song, Bing Ni, Longlong Zhang, Xiaochong He & Yi You
Additional file 5: Figure S1. Gating strategy for the detection of Th17 cells. Figure represents the result of (A) the patient with SLE compared to (B) the healthy control. Lymphocyte population was gated from PBMCs according to forward scatter area (FSC-A) characteristics and side scatter area (SSC-A) characteristics. Discrimination of single cells was performed by plotting forward scatter height (FSC-H) against forward scatter area (FSC-A). Gating strategy to discriminate T cell populations was set using...

Circular RNA circLOC101928570 suppresses systemic lupus erythematosus progression by targeting the miR-150-5p/c-myb axis

Xingwang Zhao, Rui Dong, Zhongwei Tang, Juan Wang, Chunyou Wang, Zhiqiang Song, Bing Ni, Longlong Zhang, Xiaochong He & Yi You
Abstract Background Accumulating evidence supports the implication of circular RNAs (circRNAs) in systemic lupus erythematosus (SLE). However, little is known about the detailed mechanisms and roles of circRNAs in the pathogenesis of SLE. Methods Quantitative real-time PCR was used to determine the levels of circLOC101928570 and miR-150-5p in peripheral blood mononuclear cells of SLE. Overexpression and knockdown experiments were conducted to assess the effects of circLOC101928570. Fluorescence in situ hybridization, RNA immunoprecipitation, luciferase reporter assays,...

Establishment of the prediction model and biological mechanism exploration for secondary imatinib-resistant in gastrointestinal stromal tumor

Chao Wang, Zhanlong Shen, Kewei Jiang, Zhidong Gao & Yingjiang Ye
A gastrointestinal stromal tumor (GIST) is mostly driven by the auto-activated, mutant KIT receptor tyrosine kinase gene or by the platelet-derived growth factor receptor alpha. Inhibition of KIT-signaling is the primary molecular target therapy for GIST, which is performed by the drug imatinib clinically. However, more than half of advanced or metastatic GIST develop secondary resistance to imatinib within 2 years after initiation of treatment, and the mechanism of acquired imatinib-resistant in GIST remains unclear....

Establishment of the prediction model and biological mechanism exploration for secondary imatinib-resistant in gastrointestinal stromal tumor

Chao Wang, Zhanlong Shen, Kewei Jiang, Zhidong Gao & Yingjiang Ye
A gastrointestinal stromal tumor (GIST) is mostly driven by the auto-activated, mutant KIT receptor tyrosine kinase gene or by the platelet-derived growth factor receptor alpha. Inhibition of KIT-signaling is the primary molecular target therapy for GIST, which is performed by the drug imatinib clinically. However, more than half of advanced or metastatic GIST develop secondary resistance to imatinib within 2 years after initiation of treatment, and the mechanism of acquired imatinib-resistant in GIST remains unclear....

Predictive performance of different bleeding risk scores in patients with atrial fibrillation and acute coronary syndrome or undergoing percutaneous coronary intervention

Si-Qi Lyu, Jun Zhu, Juan Wang, Shuang Wu, Han Zhang, Xing-Hui Shao & Yan-Min Yang
This study aims to evaluate the predictive values of the HAS-BLED, ORBIT, ATRIA, REACH, PARIS, and PRECISE-DAPT scores in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) who received both anticoagulant and antiplatelet therapy. 930 patients were consecutively recruited and followed up for 1 year. The primary endpoints were BARC class ≥3 bleeding and BARC class ≥2 bleeding. BARC class ≥3 bleeding occurred in 36 patients(3.9%), while...

Predictive performance of different bleeding risk scores in patients with atrial fibrillation and acute coronary syndrome or undergoing percutaneous coronary intervention

Si-Qi Lyu, Jun Zhu, Juan Wang, Shuang Wu, Han Zhang, Xing-Hui Shao & Yan-Min Yang
This study aims to evaluate the predictive values of the HAS-BLED, ORBIT, ATRIA, REACH, PARIS, and PRECISE-DAPT scores in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) who received both anticoagulant and antiplatelet therapy. 930 patients were consecutively recruited and followed up for 1 year. The primary endpoints were BARC class ≥3 bleeding and BARC class ≥2 bleeding. BARC class ≥3 bleeding occurred in 36 patients(3.9%), while...

TiO2 nanotube immobilised 5-lipoxygenase-mediated screening and isolation of anti-inflammatory active compounds from the leaves of lonicera japonica thunb

Jinhua Zhu, Danyang Zhou, Dandan Wu, Wei Liu & Xiuhua Liu
In this work, a highly effective separation approach mediated by 5-Lipoxygenase (5-LOX) was established for screening and isolation of anti-inflammatory ingredients from leaves of Lonicera japonica Thunb. (LLJT). Using 5-LOX immobilised on TiO2 nanotubes as a microreactor, the targeted screening was exploited by combining with HPLC-MS system. Four compounds confirmed as luteolin, luteoside, lonicerin, and isochlorogenic acid C and a fraction (M1) were screened out to be potent inhibitors of 5-LOX. Their anti-inflammatory activities were...

Circular RNA–microRNA–mRNA network identified circ_0007618 and circ_0029426 as new valuable biomarkers for lung adenocarcinoma

Qiang Zhang, Yungang Sun, Chao Wang & Feng Shao
Circular RNAs (circRNAs) are involved in multiple physiological processes. However, whether circRNAs function as the indicators of lung adenocarcinoma (LUAD) remains unclear. Three LUAD-related microarray datasets were downloaded from the Gene Expression Omnibus database, and overlapping differentially expressed circRNAs (DECs) in LUAD were identified. circ_0007618 and circ_0029426 were revealed to be significantly dysregulated in LUAD and verified in LUAD tissues and serum obtained in this study. Subsequently, the overall survival curve and receiver operating characteristics...

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Affiliations

  • Uppsala University
    399
  • Zhengzhou University
    133
  • Chinese Academy of Medical Sciences & Peking Union Medical College
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  • Capital Medical University
    125
  • Army Medical University
    121
  • Tongji University
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  • Fudan University
    119
  • Central South University
    118
  • Shandong Academy of Agricultural Sciences
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