Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231152549 for Noradrenaline released from locus coeruleus axons contracts cerebral capillary pericytes via α2 adrenergic receptors by Nils Korte, Greg James, Haoming You, Chanawee Hirunpattarasilp, Isabel Christie, Huma Sethi and David Attwell in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231152549 for Noradrenaline released from locus coeruleus axons contracts cerebral capillary pericytes via α2 adrenergic receptors by Nils Korte, Greg James, Haoming You, Chanawee Hirunpattarasilp, Isabel Christie, Huma Sethi and David Attwell in Journal of Cerebral Blood Flow & Metabolism

Noradrenaline (NA) release from locus coeruleus axons generates vascular contractile tone in arteriolar smooth muscle and contractile capillary pericytes. This tone allows neuronal activity to evoke vasodilation that increases local cerebral blood flow (CBF). Much of the vascular resistance within the brain is located in capillaries and locus coeruleus axons have NA release sites closer to pericytes than to arterioles. In acute brain slices, NA contracted pericytes but did not raise the pericyte cytoplasmic Ca2+...

Noradrenaline (NA) release from locus coeruleus axons generates vascular contractile tone in arteriolar smooth muscle and contractile capillary pericytes. This tone allows neuronal activity to evoke vasodilation that increases local cerebral blood flow (CBF). Much of the vascular resistance within the brain is located in capillaries and locus coeruleus axons have NA release sites closer to pericytes than to arterioles. In acute brain slices, NA contracted pericytes but did not raise the pericyte cytoplasmic Ca2+...