Data from: Metagenomic chromosome conformation capture (meta3C) unveils the diversity of chromosome organization in microorganismsMartial Marbouty, Axel Cournac, Jean-Francois Flot, Herve Marie-Nelly, Julien Mozziconacci & Romain Koszul
Genomic analyses of microbial populations in their natural environment remain limited by the difficulty to assemble full genomes of individual species. Consequently, the chromosome organization of microorganisms has been investigated in a few model species, but the extent to which the features described can be generalized to other taxa remains unknown. Using controlled mixes of bacterial and yeast species, we developed meta3C, a metagenomic chromosome conformation capture approach that allows characterizing individual genomes and their...
Data from: Comparative genomics of the dairy isolate Streptococcus macedonicus ACA-DC 198 against related members of the Streptococcus bovis/Streptococcus equinus complexKonstantinos Papadimitriou, Rania Anastasiou, Eleni Mavrogonatou, Jochen Blom, Nikos C. Papandreou, Stavros J. Hamodrakas, Stéphanie Ferreira, Pierre Renault, Philip Supply, Bruno Pot & Effie Tsakalidou
Background: Within the genus Streptococcus, only Streptococcus thermophilus is used as a starter culture in food fermentations. Streptococcus macedonicus though, which belongs to the Streptococcus bovis/Streptococcus equinus complex (SBSEC), is also frequently isolated from fermented foods mainly of dairy origin. Members of the SBSEC have been implicated in human endocarditis and colon cancer. Here we compare the genome sequence of the dairy isolate S. macedonicus ACA-DC 198 to the other SBSEC genomes in order to...
Data from: Patterns of selection on Plasmodium falciparum erythrocyte binding antigens after the colonisation of the New WorldErhan Yalcindag, Virginie Rougeron, Eric Elguero, Céline Arnathau, Patrick Durand, Sylvain Brisse, Laure Diancourt, Agnes Aubouy, Pierre Becquart, Umberto D'Alessandro, Didier Fontenille, Dionicia Gamboa, Amanda Maestre, Didier Ménard, Lise Musset, Oscar Noya, Vincent Veron, Albina Wide, Bernard Carme, Eric Legrand, Christine Chevillon, Francisco J. Ayala, François Renaud & Franck Prugnolle
Pathogens, which have recently colonized a new host species or new populations of the same host, are interesting models for understanding how populations may evolve in response to novel environments. During its colonization of South America from Africa Plasmodium falciparum, the main agent of malaria, has been exposed to new conditions in distinctive new human populations (Amerindian and populations of mixed origins), that likely exerted new selective pressures on the parasite's genome. Among the genes...
Data from: Prominent intra-specific genetic divergence within Anopheles gambiae sibling species triggered by habitat discontinuities across a riverine landscapeBeniamino Caputo, Davis Nwakanma, Francesco Paolo Caputo, Musa Jawara, Cheryll Oriero, Majidah Adiamoh, Ibrahima Dia, Lassana Konate, Vincenzo Petrarca, Joao Pinto, David J. Conway, Alessandra Della Torre, E. C. Oriero & M. Hamid-Adiamoh
The Anopheles gambiae complex of mosquitoes includes malaria vectors at different stages of speciation, whose study enables a better understanding of how adaptation to divergent environmental conditions leads to evolution of reproductive isolation. We investigated the population genetic structure of closely-related sympatric taxa that have recently been proposed as separate species (An. coluzzii and An. gambiae), sampled from diverse habitats along the Gambia River in West Africa. We characterised putatively neutral microsatellite loci as well...
Data from: Computational design of protein-based inhibitors of Plasmodium vivax subtilisin-like 1 proteaseGiacomo Bastianelli, Anthony Bouillon, Christophe Nguyen, Dung Le-Nguyen, Michael Nilges & Jean-Christophe Barale
Background: Malaria remains a major global health concern. The development of novel therapeutic strategies is critical to overcome the selection of multiresistant parasites. The subtilisin-like protease (SUB1) involved in the egress of daughter Plasmodium parasites from infected erythrocytes and in their subsequent invasion into fresh erythrocytes has emerged as an interesting new drug target. Findings: Using a computational approach based on homology modeling, protein–protein docking and mutation scoring, we designed protein–based inhibitors of Plasmodium vivax...
Data from: Phylum-wide comparative genomics unravel the diversity of secondary metabolism in CyanobacteriaAlexandra Calteau, David P. Fewer, Amel Latifi, Thérèse Coursin, Thierry Laurent, Jouni Jokela, Cheryl A. Kerfeld, Kaarina Sivonen, Jörn Piel & Muriel Gugger
Background: Cyanobacteria are an ancient lineage of photosynthetic bacteria from which hundreds of natural products have been described, including many notorious toxins but also potent natural products of interest to the pharmaceutical and biotechnological industries. Many of these compounds are the products of non-ribosomal peptide synthetase (NRPS) or polyketide synthase (PKS) pathways. However, current understanding of the diversification of these pathways is largely based on the chemical structure of the bioactive compounds, while the evolutionary...
French National Centre for Scientific Research2
Centre national de la recherche scientifique1
Max Planck Institute for Dynamics and Self Organization1
Centre de Recherches de Jouy-en-Josas1
Atomic Energy and Alternative Energies Commission1
University of California, Berkeley1
Institut Pasteur de la Guyane1
French National Institute for Agricultural Research1