14 Works

Tumor-targeted Gd-doped mesoporous Fe3O4 nanoparticles for T1/T2 MR imaging guided synergistic cancer therapy

Shaohui Zheng, Shang Jin, Min Jiao, Wenjun Wang, Xiaoyu Zhou, Jie Xu, Yong Wang, Peipei Dou, Zhen Jin, Changyu Wu, Jingjing Li, Xinting Ge & Kai Xu
In this study, a novel intelligent nanoplatform to integrate multiple imaging and therapeutic functions for targeted cancer theranostics. The nanoplatform, DOX@Gd-MFe3O4 NPs, was constructed Gd-doped mesoporous Fe3O4 nanoparticles following with the doxorubicin (DOX) loading in the mesopores of the NPs. The DOX@Gd-MFe3O4 NPs exhibited good properties in colloidal dispersity, photothermal conversion, NIR triggered drug release, and high T1/T2 relaxicity rate (r1=9.64 mM−1s−1, r2= 177.71 mM−1s−1). Benefiting from the high MR contrast, DOX@Gd-MFe3O4 NPs enabled simultaneous...

Current status and future strategies for mentoring women in neurology

Christa San Luis Nobleza, Amtul Farheen, Ilena George, Divya Singhal, Regina Troxell, Jyoti Pillai, Logan Schneider, Catherine Lomen-Hoerth, Jennifer Graves & Stefano Sandrone
The American Academy of Neurology's (AAN) 2017 Gender Disparity Report identified improving mentorship as a key intervention to fill the leadership and pay gaps for women in neurology. Here we summarize the literature on mentoring women, provide an outline of ideal components of programs geared toward closing gender gaps, and present a mentoring program for AAN members. The strategies discussed share similarities with those for closing gaps related to race, ethnicity and religion. Developing effective...

Higher probability of tick infestation reveals a hidden cost of army ant-following in Amazonian birds

Alan Fecchio, Thiago F. Marins, Maria Ogrzewalska, Fabio Schunck, Jason D. Weckstein & Raphael I. Dias
The foraging specialization of army-ant-following birds has long intrigued ecologists and provided numerous questions such as why, how, and when did this foraging guild specialization arise and evolve. Many of the answers to these questions have focused on ecological interactions such as predation and competition, whereas little has been done to study the potential effects of host-parasite interactions among members of this foraging guild. Using 1,177 Amazonian birds from 187 species, we studied the probability...

Reconciling the Differences in Aggregate U.S. Wage Series

Julien Champagne, André Kurmann & Jay Stewart
Average hourly real wage series from the Labor Productivity and Costs (LPC) program and the Current Employment Statistics (CES) program have evolved very differently over the past decades. While the LPC wage has grown consistently over time and become markedly more volatile since the mid-1980s, the CES wage stagnated from the early 1970s to the mid-1990s and experienced a substantial drop in volatility since the mid-1980s. These differences are due to the divergent evolution of...

Systematics and conservation of an endemic radiation of Accipiter hawks in the Caribbean islands

Therese A. Catanach, Matthew H. Halley, Julie M. Allen, Jeff A. Johnson, Russell Thorstrom, Samantha Palhano, Chyna Poor Thunder, Julio C. Gallardo & Jason D. Weckstein
More than one third of the bird species found in the Caribbean are endemic to a set of neighboring islands or a single island. However, we have little knowledge of the evolutionary history of the Caribbean avifauna and the lack of phylogenetic studies limits our understanding of the extent of endemism in the region. The Sharp-shinned Hawk (Accipiter striatus) occurs widely across the Americas and includes three endemic Caribbean taxa: venator on Puerto Rico, striatus...

Population structure of giant clams (sub-family: Tridacninae) across Palau: implications for conservation

Lincoln Rehm, Lincy Marino, Randa Jonathan, Amanda Holt, Richard McCourt & Alison Sweeney
Giant clams (Sub-family: Tridacninae) are an important food and economic resource for the Republic of Palau. Previous surveys of giant clams conducted over 20 years ago found diverse, localized populations across Helen Reef and the Rock Islands Southern Lagoon. This study updates population structure data for Palauan giant clams and investigates the impacts of conservation on these important bivalves. We surveyed eleven sites within fringing, barrier, atoll, and oceanic reefs across the Palauan archipelago (total...

Did shell-crushing predators drive the evolution of ammonoid septal shape?

Erynn Johnson, Briana DiMarco, David Peterman, Aja Carter & Warren Allmon
For centuries, paleontologists have sought functional explanations for the uniquely complex internal walls (septa) of ammonoids, extinct shelled cephalopods. Ammonoid septa developed increasingly complex fractal margins, unlike any modern shell morphologies, throughout more than 300 million years of evolution. Some have suggested these morphologies provided increased resistance to shell-crushing predators. We perform the first physical compression experiments on model ammonoid septa using controlled, theoretical morphologies generated by computer-aided design and 3D printing. These biomechanical experiments...

Tumor-targeted Gd-doped mesoporous Fe3O4 nanoparticles for T1/T2 MR imaging guided synergistic cancer therapy

Shaohui Zheng, Shang Jin, Min Jiao, Wenjun Wang, Xiaoyu Zhou, Jie Xu, Yong Wang, Peipei Dou, Zhen Jin, Changyu Wu, Jingjing Li, Xinting Ge & Kai Xu
In this study, a novel intelligent nanoplatform to integrate multiple imaging and therapeutic functions for targeted cancer theranostics. The nanoplatform, DOX@Gd-MFe3O4 NPs, was constructed Gd-doped mesoporous Fe3O4 nanoparticles following with the doxorubicin (DOX) loading in the mesopores of the NPs. The DOX@Gd-MFe3O4 NPs exhibited good properties in colloidal dispersity, photothermal conversion, NIR triggered drug release, and high T1/T2 relaxicity rate (r1=9.64 mM−1s−1, r2= 177.71 mM−1s−1). Benefiting from the high MR contrast, DOX@Gd-MFe3O4 NPs enabled simultaneous...

Disrupting Intergenerational Poverty Through a Place-Based Education Initiative: A Review of Promise Neighborhoods in their First Decade

Kim Sterin
This study explains the complexities of attainment, implementation, and evaluation of the U.S. Department of Education’s Promise Neighborhood (PN) initiative. PNs seek to disrupt intergenerational poverty through a place-based education initiative that creates a pipeline of health, social, and education resources within an economically distressed neighborhood in an urban, rural, or tribal setting. The PN implementation grantees manage a network of school-community partnerships aiming to support students from cradle to career. This study includes an...

Neuroanatomical differentiation in dimorphic male C. pallida and A. dawsoni bees (volumes)

Meghan Barrett, Sophi Schneider, Purnima Sachdeva, Angelina Gomez, Stephen Buchmann & Sean O'Donnell
Alternative reproductive tactics (ARTs) occur when there is categorical variation in the reproductive strategies of a sex within a population. These different behavioral phenotypes can expose animals to distinct cognitive challenges, which may be addressed through neuroanatomical differentiation. The dramatic phenotypic plasticity underlying ARTs provides a powerful opportunity to study how intraspecific nervous system variation can support distinct cognitive abilities. We hypothesized that conspecific animals pursuing ARTs would exhibit dissimilar brain architecture. Dimorphic males of...

Precipitation and vegetation shape patterns of genomic and craniometric variation in the Central African rodent Praomys misonnei

Katy Morgan, Jean Francois Mboumba, Stephan Ntie, Patrick Mickala, Courtney A. Miller, Ying Zhen, Ryan J. Harrigan, Vinh Le Underwood, Kristen Ruegg, Eric B. Fokam, Geraud C. Tasse Taboue, Paul R. Sesink Clee, Trevon Fuller, Thomas B. Smith & Nicola M. Anthony
Predicting species capacity to respond to climate change is an essential first step in developing effective conservation strategies. However, conservation prioritization schemes rarely take evolutionary potential into account. Ecotones provide important opportunities for diversifying selection and may thus constitute important reservoirs of standing variation, increasing the capacity for future adaptation. Here we map patterns of environmentally-associated genomic and craniometric variation in the central African rodent Praomys misonnei to identify areas with the greatest turnover in...

Phylogenomics of the bumblebee catfishes (Siluriformes: Pseudopimelodidae) using ultraconserved elements

Gabriel Costa e Silva, Bruno F. Melo, Fábio Fernandes Roxo, Luz E. Ochoa, Oscar Akio Shibatta, Mark H. Sabaj, Ricardo C. Benine & Claudio Oliveira
Data matrix of UCEs.

Avian community mist net survey data from Luba/Ureca road elevational gradient, Bioko Island, Equatorial Guinea

Steven Miller, Joris Wiethase, Amancio Etingue, Elaine Franklin, Maximiliano Fero, Jared Wolfe, Mary Gonder & Luke Powell
Understanding interactive effects between anthropogenic disturbance and abiotic factors on species turnover can help identify and prioritize conservation of potentially vulnerable tropical bird communities. We investigated potential factors influencing avian understory community composition along a recently constructed road across three elevations (300, 800 and 1200 m), each with two sampling sites (road edge vs interior forest), over a four-year period on Bioko Island, Equatorial Guinea. Obligate ant following species were the most abundant guild sampled...

Diet overlap among non-native trout species and native Cutthroat Trout (Oncorhynchus clarkii) in two U.S. ecoregions

Mario Minder, Emily Arsenault, Bolortsetesg Erdenee, Alain Maasri & Mark Pyron
The invasion of freshwater ecosystems by non-native species can constitute a significant threat to native species and ecosystem health. Non-native trouts have long been stocked in areas where native trouts occur and have negatively impacted native trouts through predation, competition, and hybridization. This study encompassed two seasons of sampling efforts across two ecoregions of the western United States: The Great Basin in summer 2016 and the Yellowstone River Basin in summer 2017. We found significant...

Registration Year

  • 2021
    14

Resource Types

  • Dataset
    10
  • Text
    4

Affiliations

  • Drexel University
    13
  • Chinese Academy of Tropical Agricultural Sciences
    2
  • Beijing Tian Tan Hospital
    2
  • North West Agriculture and Forestry University
    2
  • Zhejiang University
    2
  • Zunyi Medical University
    2
  • Key Laboratory of Guangdong Province
    2
  • Sichuan University
    2
  • Affiliated Hospital of Xuzhou Medical College
    2
  • Fudan University
    2