1,811 Works

Genotypes of Swan Geese Anser cygnoides using 17 nuclear microsatellite loci at 14 locations.

Qin Zhu, Iderbat Damaba, Qingshan Zhao, Kunpeng Yi, Nyambayar Batbayar, Tseveenmyadag Natsagdorj, Davaasuren Batmunkh, Xin Wang, Sonia Rozenfeld, Sachiko Moriguchi, Aibin Zhan, Lei Cao & Anthony David Fox
Dispersal affects the spatial distribution and population structure of species.Dispersal is often male-biased in mammals while female-biased in birds, with the notable exception of the Anatidae. In this study, we tested genetic evidence for sex-biased dispersal (SBD) in the Swan Goose Anser cygnoides, an Asian endemic and IUCN vulnerable species, which has been increasingly restricted to breeding on Mongolian steppe wetlands. We analyzed the genotypes of 278 Swan Geese samples from 14 locations at 14...

Data from: Determining structural and chemical heterogeneities of surface species at the single-bond limit

Shijing Tan, Jiayu Xu, Xiang Zhu, Yao Zhang, Bin Li, Yunzhe Tian, Huan Shan, Xuefeng Cui, Aidi Zhao, Zhenchao Dong, Yi Luo, Jinlong Yang, Bing Wang & J.G. Hou
The structure determination of surface species has long been a challenge because of their rich chemical heterogeneities. Modern tip-based microscopic techniques can resolve heterogeneities from their distinct electronic, geometric, and vibrational properties at the single-molecule level but with limited interpretation from each. Here, we combined scanning tunneling microscopy (STM), noncontact atomic force microscopy (AFM), and tip-enhanced Raman scattering (TERS) to characterize an assumed inactive system, pentacene on the Ag(110) surface. This enabled us to unambiguously...

A droplet reactor on a super-hydrophobic surface allows control and characterization of amyloid fibril growth

Peng Zhang, Enzo Di Fabrizio, Manola Moretti, Marco Allione, Yuansi Tian, Javier Ordonez-Loza, Davide Altamura, Cinzia Giannini, Bruno Torre, Gobind Das, Erqiang Li, Sigurdur T. Thoroddsen, Mani Sarathy, Ida Autiero, Andrea Giugni, Francesco Gentile, Natalia Malara & Monica Marini
Methods to produce protein amyloid fibrils, in vitro, and in situ structure characterization, are of primary importance in biology, medicine, and pharmacology. We first demonstrated the droplet on a super-hydrophobic substrate as the reactor to produce protein amyloid fibrils with real-time monitoring of the growth process by using combined light-sheet microscopy and thermal imaging. The molecular structures were characterized by Raman spectroscopy, X-ray diffraction and X-ray scattering. We demonstrated that the convective flow induced by...

Additional file 1 of G6PD promotes cell proliferation and dexamethasone resistance in multiple myeloma via increasing anti-oxidant production and activating Wnt/β-catenin pathway

Rui Li, Mengying Ke, Mingming Qi, Zhenru Han, Yuhao Cao, Zhendong Deng, Jinjun Qian, Ye Yang & Chunyan Gu
Additional file 1: Table S1. The clinical characteristics of 70 MM patients.

Additional file 2 of G6PD promotes cell proliferation and dexamethasone resistance in multiple myeloma via increasing anti-oxidant production and activating Wnt/β-catenin pathway

Rui Li, Mengying Ke, Mingming Qi, Zhenru Han, Yuhao Cao, Zhendong Deng, Jinjun Qian, Ye Yang & Chunyan Gu
Additional file 2: Fig S1. Growth curves of ARP1/H929 G6PD-OE/KD cells cultured for 7 days. Fig S2 WB analysis of mTOR and AKT in G6PD-OE/KD cells. Fig. S3 Wnt3a partially restores the suppressed expression of G6PD and β-catenin by RRX-001.

Neutrophil activation and NETosis are the predominant drivers of airway inflammation in an OVA/CFA/LPS induced murine model

Mengling Xia, Fei Xu, Hangqi Ni, Qing Wang, Ruhui Zhang, Yafang Lou & Jianying Zhou
Abstract Background Asthma is one of the most common chronic diseases that affects more than 300 million people worldwide. Though most asthma can be well controlled, individuals with severe asthma experience recurrent exacerbations and impose a substantial economic burden on healthcare system. Neutrophil inflammation often occurs in patients with severe asthma who have poor response to glucocorticoids, increasing the difficulty of clinical treatment. Methods We established several neutrophil-dominated allergic asthma mouse models, and analyzed the...

Additional file 4 of A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology

Yongqun He, Hong Yu, Anthony Huffman, Asiyah Yu Lin, Darren A. Natale, John Beverley, Ling Zheng, Yehoshua Perl, Zhigang Wang, Yingtong Liu, Edison Ong, Yang Wang, Philip Huang, Long Tran, Jinyang Du, Zalan Shah, Easheta Shah, Roshan Desai, Hsin-hui Huang, Yujia Tian, Eric Merrell, William D. Duncan, Sivaram Arabandi, Lynn M. Schriml, Jie Zheng … & Barry Smith
Additional file 4: Supplemental Table 3. Protein Ontology representation of SARS-CoV-2 proteins. Comparative information in RefSeq and UniProtKB is also provided.

Failure pattern and suggestions for target volume delineation of carcinoma showing thymus-like differentiation treated with intensity-modulated radiotherapy

Fang-Fang Kong, Guang-Sen Pan, Rui-Ping Zhai, Cheng-Run Du, Xia-Yun He, Chun-Ying Shen, Xue-Guan Lu, Tuan-Qi Sun, Yu Wang, Qing-Hai Ji, Chao-Su Hu & Hong-Mei Ying
Abstract Background To review our long-term clinical experience, analyze the failure patterns, and give suggestions for target volume delineation of carcinoma showing thymus-like differentiation (CASTLE) treated with intensity-modulated radiotherapy (IMRT). Methods From April 2008 to May 2019, 30 patients with CASTLE treated by postoperative or radical IMRT in our center were retrospectively reviewed. A total dose of 56-60 Gy in 28–30 fractions was prescribed to patients without residual disease and 66 Gy in 33 fractions...

Additional file 3 of Genomic characteristics of two breast malignant phyllodes tumors during pregnancy and lactation identified through whole-exome sequencing

Tinge Lei, Mengjia Shen, Xu Deng, Yongqiang Shi, Yan Peng, Hui Wang & Tongbing Chen
Supplementary Material 3

Additional file 1 of Failure pattern and suggestions for target volume delineation of carcinoma showing thymus-like differentiation treated with intensity-modulated radiotherapy

Fang-Fang Kong, Guang-Sen Pan, Rui-Ping Zhai, Cheng-Run Du, Xia-Yun He, Chun-Ying Shen, Xue-Guan Lu, Tuan-Qi Sun, Yu Wang, Qing-Hai Ji, Chao-Su Hu & Hong-Mei Ying
Supplementary Material 1

Hydrocarbon regulation and lower temperature pyrolysis of balikun oil shale kerogen

Fei Liu, Weiguang Shi, Tianbao Liu, Wei Li, Liang Sun, Xiangbin Liu, Changming Zhao, Benxian Li, Sunhua Deng, Zhaohui Dong, Chengwu Xu, Xiaofei Fu & Xiuling Yan
Oil shale kerogen is a kind of composite nature of fossil energy polymer. Kerogen pyrolysis is a feasible and alternative strategy to produce fossil fuels from shales. However, the disadvantages including the high energy consumption, the high cost, and the low hydrocarbon conversion, significantly hinder the development and utilization of unconventional hydrocarbon resources. Herein, the hexagonal crystal structural layered double hydroxides (LDHs) with the Ni/Fe ratio of 5.64:2.36 is proposed as pyrolysis catalyst to improve...

Effects of physiotherapeutic scoliosis-specific exercise in patients with mild juvenile scoliosis

Wangshu Yuan, Hai Wang, Keyi Yu, Jianxiong Shen, Lixia Chen, Ying Liu & Youxi Lin
Abstract Study design A combined retrospective and prospective analysis on the therapeutic effect of physiotherapeutic scoliosis-specific exercise (PSSE) in mild juvenile idiopathic scoliosis (JIS) patients. Background At present, patients with mild JIS are generally treated by observation without any interventional treatment. This study analyzed the effects of PSSE on mild JIS, which provided a new approach for the treatment of JIS. Method A total of 52 patients with mild JIS (Cobb angle 10–19°), aged 4–9...

Fig. S1. Myelopoiesis in Tg(drl:hoxa9;hsp70:meis1) embryos receiving one time of HS induction or daily HS induction. Embryos were assayed by WISH for mpx at 5 dpf. ;Fig. S2. A subgroup of Tg(drl:hoxa9;hsp70:meis1) adult fish develops AML-like phenotypes after one time HS in the embryos.;Fig. S3. Flow cytometry assay of the whole kidney marrow cells in WT, Tg(drl:hoxa9) and Tg(drl:hoxa9;hsp70:meis1) adult fish.;Fig. S4. Genome-wide transcriptional analysis of the kidney marrow cell of WT and Tg(drl:hoxa9;hsp70:meis1) adult fish.;Fig. S5. May-Grünwald and Giemsa staining of the peripheral blood cells from 7-dpf Tg(drl:hoxa9;hsp70:meis1) embryos with or without Lef treatment.

Wei Wang, Hongji Li, Mengling Huang, Xue Wang, Wei Li, Xiaoqing Qian & Lili Jing
Fig. S1. Myelopoiesis in Tg(drl:hoxa9;hsp70:meis1) embryos receiving one time of HS induction or daily HS induction. Embryos were assayed by WISH for mpx at 5 dpf. HS, heat-shock; NS, no statistical significance. ;Fig. S2. A subgroup of Tg(drl:hoxa9;hsp70:meis1) adult fish develops AML-like phenotypes after one time HS in the embryos. Tg(drl:hoxa9;hsp70:meis1) embryos were HS induced at 24 hpf once and grown to adulthood. (A) May-Grünwald/Giemsa staining of the whole kidney marrow blood cells and peripheral...

Supplementary material from \"Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance\"

Wei Wang, Hongji Li, Mengling Huang, Xue Wang, Wei Li, Xiaoqing Qian & Lili Jing
HOXA9 and MEIS1 are co-expressed in over 50% of acute myeloid leukaemia (AML) and play essential roles in leukemogenesis, but the mechanisms involved are poorly understood. Diverse animal models offer valuable tools to recapitulate different aspects of AML and link in vitro studies to clinical trials. We generated a double transgenic zebrafish that enables hoxa9 overexpression in blood cells under the draculin (drl) regulatory element and an inducible expression of meis1 through a heat shock...

Additional file 4 of Functional differentiation determines the molecular basis of the symbiotic lifestyle of Ca. Nanohaloarchaeota

Yuan-Guo Xie, Zhen-Hao Luo, Bao-Zhu Fang, Jian-Yu Jiao, Qi-Jun Xie, Xing-Ru Cao, Yan-Ni Qu, Yan-Lin Qi, Yang-Zhi Rao, Yu-Xian Li, Yong-Hong Liu, Andrew Li, Cale Seymour, Marike Palmer, Brian P. Hedlund, Wen-Jun Li & Zheng-Shuang Hua
Additional file 4. All commands, scripts, and R codes are included.

Thrombus-targeted nano-agents for NIR-II diagnostic fluorescence imaging-guided flap thromboembolism multi-model therapy

Zichen Cao, Xinyu Zhang, Zheng Wei, Chuanhui Song, Huihui Zou, Jianchuan Ran, Hongbo Zhang, Diya Xie, Shengwei Han, Yufeng Wang, Yu Cai & Wei Han
Abstract In oral and maxillofacial surgery, flap repair is essential to the quality of postoperative life. Still, thrombosis is fatal for the survival of the flaps. Besides, some postoperative thrombotic diseases, such as pulmonary embolism, also intimidate patients’ life. The traditional diagnostic methods are still limited by a large amount of hardware and suffer from inconvenience, delay, and subjectivity. Moreover, the treatments mainly rely upon thrombolytics, such as urokinase (UK) plasminogen activator, which may cause...

Additional file 3 of Reading activities compensate for low education-related cognitive deficits

Yue Wang, Shinan Wang, Wanlin Zhu, Na Liang, Chen Zhang, Yuankun Pei, Qing Wang, Shiping Li & Jiong Shi
Additional file 3: Supplemental Table 3. Cognitive performance of participants using different reading materials.

Reading activities compensate for low education-related cognitive deficits

Yue Wang, Shinan Wang, Wanlin Zhu, Na Liang, Chen Zhang, Yuankun Pei, Qing Wang, Shiping Li & Jiong Shi
Abstract Background The incidence of cognitive impairment is increasing with an aging population. Developing effective strategies is essential to prevent dementia. Higher education level is associated with better baseline cognitive performance, and reading activities can slow down cognitive decline. However, it is unclear whether education and reading activities are synergistic or independent contributors to cognitive performance. Methods This was a sub-study of an ongoing prospective community cohort of China National Clinical Research Center Alzheimer’s Disease...

Supplementary document for Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method - 6063130.pdf

Hao Liang, Qi Wang, Xueguang Yuan, Hao Liu, Jiyu Xu, Yangan Zhang, Kai Liu, Yongqing Huang & Xiaomin Ren
Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method: supplemental document

Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method

Hao Liang, Qi Wang, Xueguang Yuan, Hao Liu, Jiyu Xu, Yangan Zhang, Kai Liu, Yongqing Huang & Xiaomin Ren
Topology optimization has been widely adopted in the inverse design of nanophotonic devices due to low computational cost, which unfortunately produces intermediate relative permittivity values that fail to meet fabrication constraints. Additionally, the postprocessing required inevitably increases the complexity of the inverse design. In this Letter, we propose an adaptive projection method for topology optimization, in which a two-level hierarchical hyperbolic tangent projection function with linear increment and differentiation was constructed and applied to eliminate...

Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method

Hao Liang, Qi Wang, Xueguang Yuan, Hao Liu, Jiyu Xu, Yangan Zhang, Kai Liu, Yongqing Huang & Xiaomin Ren
Topology optimization has been widely adopted in the inverse design of nanophotonic devices due to low computational cost, which unfortunately produces intermediate relative permittivity values that fail to meet fabrication constraints. Additionally, the postprocessing required inevitably increases the complexity of the inverse design. In this Letter, we propose an adaptive projection method for topology optimization, in which a two-level hierarchical hyperbolic tangent projection function with linear increment and differentiation was constructed and applied to eliminate...

Supplementary material from \"The silkworm gustatory receptor BmGr63 is dedicated to the detection of isoquercetin in mulberry\"

Shaoyu ZHANG, Jiaqi Tang, Yunfeng Li, Dong Li, Guo Chen, Lin Chen, Zhen Yang & Ningjia he
Gustatory systems in phytophagous insects are used to perceive feeding stimulants and deterrents and are involved in insect decisions to feed on particular plants. During the process, gustatory receptors (Gr) can recognize diverse phytochemicals and provide a molecular basis for taste perception. The silkworm, as a representative Lepidoptera species, has developed a strong feeding preference for mulberry leaves. The mulberry-derived flavonoid glycoside, isoquercetin, is required to induce feeding behaviours. However, the corresponding Gr for isoquercetin...

Supplementary material from \"The silkworm gustatory receptor BmGr63 is dedicated to the detection of isoquercetin in mulberry\"

Shaoyu ZHANG, Jiaqi Tang, Yunfeng Li, Dong Li, Guo Chen, Lin Chen, Zhen Yang & Ningjia he
Gustatory systems in phytophagous insects are used to perceive feeding stimulants and deterrents and are involved in insect decisions to feed on particular plants. During the process, gustatory receptors (Gr) can recognize diverse phytochemicals and provide a molecular basis for taste perception. The silkworm, as a representative Lepidoptera species, has developed a strong feeding preference for mulberry leaves. The mulberry-derived flavonoid glycoside, isoquercetin, is required to induce feeding behaviours. However, the corresponding Gr for isoquercetin...

'UK Lipoedema' cohort GWAS data 2021

Sara Dobbins, Dionysios Grigoriadis, Pia Ostergaard, Ege Sackey, Alan Pittman, Katie Riches, Malou van Zanten, Glen Brice, Ruth England, Vaughan Keeley, Kristiana Gordon, Liang Dong, David Savage, Mike Mills, Peter Mortimer & Steve Jeffery
Data from "Investigations of Clinical Characteristics and Genome Associations in the 'UK Lipoedema' Cohort" Grigoriadis et al, Plos One Post QC dataset (in plink format) on 130 GWAS cases from the discovery series. Scripts used to produce this dataset and for its analysis can be found on GitHub (https://github.com/digrigor/SGUL_UK_Lipoedema_GWAS). The full PLOS paper can be accessed at: https://doi.org/10.1371/journal.pone.0274867 or via the references below.

Genome of the sea anemone Exaiptasia pallida and transcriptome profiles during tentacle regeneration

Cheryl W.Y. Shum, Wenyan NONG, Wai Lok So, Zhe Qu, Ho-Yin Yip, Thomas Swale, Put O. Ang, King Ming Chan, Ting-Fung Chan, Ka-Hou Chu, Apple P.Y. Chui, Kwok-Fai Lau, Sai-ming Ngai, Fei Xu, Eve Gazave, Michel Veroort & Jerome H.L. Hui
Annotation files of Genome of the sea anemone Exaiptasia pallida.
Reference: SHUM, C., et al. Genome of the sea anemone Exaiptasia pallida and transcriptome profiles during tentacle regeneration. Frontiers in cell and developmental biology, 2022, 10.

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