Infants recovering from anesthesia are at risk of life threatening Postoperative Apnea (POA). POA events are rare, and so the study of POA requires the analysis of long cardiorespiratory records. Manual scoring is the preferred method of analysis for these data, but it is limited by low intra- and inter-scorer repeatability. Furthermore, recommended scoring rules do not provide a comprehensive description of the respiratory patterns. This work describes a set of manual scoring tools that...

Additional file 1: Table S1. Multivariable probit regression of determinants associated with USC. Fig. S1. The calibration curves for the nomogram. Table S2. Probability of the elderly with CVD who would most or be least likely to choose primary care facilities as their USC. Table S3. Probability of the elderly with CVD who would most or be least likely to choose public primary care facilities as their USC.

Additional file 1. Protocol for scoping review.

Objective: To assess the frequency of biologically-defined Alzheimer’s disease (AD) in relation to age, sex and APOEε4, as well as rates of discordance between clinically- and biologically defined AD. Methods: We assessed cognitively unimpaired (CU) elderly (n=166), amnestic MCI (n=77) and probable AD dementia (n=62) subjects who underwent evaluation by dementia specialists and neuropsychologists in addition to amyloid-PET with [18F]AZD4694 and tau-PET with [18F]MK6240. Individuals were grouped according to their AD biomarker profile. Positive predictive...

The internet is an increasingly influential actor and arena for debating emerging sustainability controversies, but studies often overlook the role of visualisations in online spreading of information. This paper offers a way to better understand this role: what images do competing online actors use, are there differences between opponents and proponents, differences between internet regions, and are there shifts in their online visualisations over time? Adopting a controversy studies perspective and the digital methods approach,...

mitochondrial Unfolded Protein Response ATFS-1 targets

Supplemental material, sj-docx-2-cjk-10.1177_20543581221150675 for Living Donor Kidney Transplantation in Quebec: A Qualitative Case Study of Health System Barriers and Facilitators by Anna Horton, Katya Loban, Marie-Chantal Fortin, Sylvie Charbonneau, Peter Nugus, Michel R. Pâquet, Prosanto Chaudhury, Marcelo Cantarovich and Shaifali Sandal in Canadian Journal of Kidney Health and Disease

Abstract Background More people with rare diseases likely receive disease education and emotional and practical support from peer-led support groups than any other way. Most rare-disease support groups are delivered outside of the health care system by untrained leaders. Potential benefits may not be achieved and harms, such as dissemination of inaccurate information, may occur. Our primary objective was to evaluate the effects of a rare-disease support group leader education program, which was developed collaboratively...

Abstract Purpose To inform recommendations by the Canadian Task Force on Preventive Health Care on potentially inappropriate prescribing and over-the-counter (OTC) medication use among adults aged 65 years and older in primary care settings. This protocol outlines the planned scope and methods for a systematic review of the benefits and harms and acceptability of interventions to reduce potentially inappropriate prescriptions and OTC medication use. Methods De novo systematic reviews will be conducted to synthesize the...

Supplemental material, sj-pdf-1-smm-10.1177_09622802221139233 for Standard error estimation in meta-analysis of studies reporting medians by Sean McGrath, Stephan Katzenschlager, Alexandra J Zimmer, Alexander Seitel, Russell Steele and Andrea Benedetti in Statistical Methods in Medical Research

Supplemental material, sj-pdf-1-msj-10.1177_13524585231151953 for A national case–control study investigating demographic and environmental factors associated with NMOSD by Dalia L Rotstein, Christina Wolfson, Robert Carruthers, Mark S Freedman, Sarah A Morrow, Liesly Lee, Jodie M Burton, Rosane Nisenbaum, Andrea Konig, Sandra Magalhaes and Ruth Ann Marrie in Multiple Sclerosis Journal

The COVID-19 pandemic had devastating effects around the world, yet it was not experienced equally by all. The emergence of the virus has been linked with the intensification of discrimination and inequities, as well as other systemic issues already present in society prior to the pandemic. The CoVivre Program was created with the mission to facilitate and accelerate initiatives aimed at reducing socioeconomic and health disparities caused by the COVID-19 pandemic in the Greater Montreal...

Additional file 6: Mount Sinai investigators.

Abstract Introduction Severe COVID-19 leads to important changes in circulating immune-related proteins. To date it has been difficult to understand their temporal relationship and identify cytokines that are drivers of severe COVID-19 outcomes and underlie differences in outcomes between sexes. Here, we measured 147 immune-related proteins during acute COVID-19 to investigate these questions. Methods We measured circulating protein abundances using the SOMAscan nucleic acid aptamer panel in two large independent hospital-based COVID-19 cohorts in Canada...

Additional file 2: Sample code for the generalized additive models.

Objective: Mild traumatic brain injury (mTBI) has been insufficiently researched and its definition remains elusive. Investigators are confronted by heterogeneity in patients, mechanism of injury and outcomes. Findings are thus often limited in generalizability and clinical application. Serum protein biomarkers are increasingly assessed to enhance prognostication of outcomes but their translation into clinical practice has yet to be achieved. A systematic review was performed to describe the adult populations included and enrolled in studies that...

Most HIV-infected patients who initiate combination antiretroviral therapy experience a viral load decline in several phases. These phases are characterized by different rates of viral load decay that decrease when transitioning from one phase to the next. There is no consensus as to the origin of these phases. One hypothesis put forward is that short- and long-lived infected cells are responsible for the first and second phases of decay, respectively. However, significant differences in drug...

Additional file1. S1: Examples of support groups for people with systemic sclerosis.

Additional file3. S3: Detailed trial outcome measures.

Additional file3. S3: Detailed trial outcome measures.

Additional file4. S4: Statistical analysis plan.

Additional file5. S5: Trial outcomes for intent to treat and adjusted intent to treat with complete cases only (no imputation).

Additional file 2. Search strategies.

Additional file 2. Search strategies.

Additional file 3. List of grey literature relevant websites.