2 Works

Unobtrusive tracking of interpersonal orienting and distance predicts the subjective quality of social interactions

Juha M Lahnakoski, Paul AG Forbes, Cade McCall & Leonhard Schilbach
Interpersonal coordination of behavior is essential for smooth social interactions. Measures of interpersonal behavior, however, often rely on subjective evaluations, invasive measurement techniques or gross measures of motion. Here, we constructed an unobtrusive motion tracking system that enables detailed analysis of behavior at the individual and interpersonal levels, which we validated using wearable sensors. We evaluate dyadic measures of joint orienting and distancing, synchrony and gaze behaviors to summarize data collected during natural conversation and...

Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB1 receptors

Juan Paraiso-Luna, Jose Aguareles, Ricardo Martin, Ane C. Ayo-Martin, Daniel Garcia-Rincon, Samuel Simon-Sanchez, Adan De Salas-Quiroga, Javier Diaz-Alonso, Elena Garcia-Taboada, Isabel Liste, Jose Sanchez-Prieto, Silvia Cappello, Manuel Guzman, Ismael Galve-Roperh & Carlos Costas-Insua
The endocannabinoid (eCB) system, via cannabinoid CB1 receptor, regulates neurodevelopment by controlling neural progenitor proliferation and neurogenesis. CB1 receptor signalling in vivo drives corticofugal deep layer projection neuron development through the regulation of BCL11B and Satb2 transcription factors. Here, we investigated the role of eCB signalling in mouse pluripotent embryonic stem cell-derived neuronal differentiation. Characterization of the eCB system revealed increased expression of eCB-metabolizing enzymes, eCB ligands and CB1 receptors along neuronal differentiation. CB1 receptor...

Registration Year

  • 2020
    2

Resource Types

  • Dataset
    2

Affiliations

  • Max Planck Institute of Psychiatry
    2
  • Instituto de Salud Carlos III
    1
  • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
    1
  • Forschungszentrum Jülich
    1
  • Complutense University of Madrid
    1
  • University of Vienna
    1
  • University of York
    1