5 Works

Cerebral Vasoregulation in Diabetes

Vera Novak & Laura Mendez
This observational study evaluated the effects of type 2 diabetes on cerebral vasoregulation and functional outcomes, measured by blood flow responses to hypocapnia and hypercapnia, Valsalva maneuver, head-up tilt, and sit-to-stand test. This dataset contains 37 diabetic participants and 49 controls (aged 55 to 75 years) with continuous measurements of cerebral blood flow using transcranial Doppler and MRI, heart rate, blood pressure, and respiratory parameters, balance, walking, laboratory and retinopathy measures.

GnRH deficient patients with congenital hypogonadotropic hypogonadism: Novel genetic findings in ANOS1, RNF216, WDR11, FGFR1, CHD7 and POLR3A genes

Vassos Neocleous, Pavlos Fanis, Meropi Toumba, George Tanteles, Melpo Schiza, Feride Cinarli, Nicolas Nicolaides, Anastasis Oulas, George Spyrou, Christos Mantzoros, Dimitrios Vlachakis, Nicos Skordis & Leonidas Phylactou
Background: Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disease caused by Gonadotropin-Releasing Hormone (GnRH) deficiency. So far a limited number of variants in several genes have been associated with the pathogenesis of the disease. In this original research and review manuscript the retrospective analysis of known variants in ANOS1 (KAL1), RNF216, WDR11, FGFR1, CHD7 and POLR3A genes is described, along with novel variants identified in patients with CHH by the present study. Methods: Seven...

Orthostatic hypotension, dizziness, neurology outcomes, and death in older adults, supplement methods & tables, STROND checklist

Stephen Juraschek, , Oscar L. Lopez, John S Gottdiener, Lewis A Lipsitz, Lewis H. Kuller & Kenneth J Mukamal
Objective To test the hypothesis that orthostatic hypotension (OH) might cause cerebral hypoperfusion and injury, we examined the longitudinal relationship between orthostatic hypotension (OH) or orthostatic symptoms and incident neurologic outcomes in a community population of older adults. Methods Cardiovascular Health Study (CHS) participants (≥65yrs) without dementia or stroke had blood pressure (BP) measured after lying 20-minutes and after standing 3-minutes. Participants reported dizziness immediately upon standing and any dizziness in the past 2wks. OH...

International consensus guidance for management of myasthenia gravis

Pushpa Narayanaswami
OBJECTIVE: To update the 2016 formal consensus-based guidance for the management of myasthenia gravis (MG) based on the latest evidence in the literature. METHODS: In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to develop treatment guidance for MG, and a panel of 15 international experts was convened. The RAND/UCLA appropriateness method was used to develop consensus recommendations pertaining to seven treatment topics. In February 2019, the international panel was reconvened...

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo: RNAseq dataset

Eben Estell, Phuong T Le, Yosta Vegting, Hyeonwoo Kim, Christiane Wrann, Mary L Bouxsein, Kenichi Nagano, Roland Baron, Bruce M Spiegelman & Clifford J Rosen
Irisin, a skeletal-muscle secreted myokine, facilitates muscle-bone crosstalk and skeletal remodeling in part by its action on osteoblasts and osteocytes. In this study, we investigated whether irisin directly regulates osteoclasts. In vitro, irisin (2–10 ng/mL) increased osteoclast differentiation in C57BL/6J mouse bone marrow progenitors; however, this increase was blocked by a neutralizing antibody to integrin αVβ5. Irisin also increased bone resorption on several substrates in situ. RNAseq revealed differential gene expression induced by irisin including...

Registration Year

  • 2020
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Resource Types

  • Dataset
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Affiliations

  • Beth Israel Deaconess Medical Center
    5
  • Harvard Medical School
    2
  • University of Washington
    1
  • University of Pittsburgh
    1
  • Cyprus Institute of Neurology and Genetics
    1
  • Dana-Farber Cancer Institute
    1
  • Maine Medical Center Research Institute
    1
  • Agricultural University of Athens
    1
  • University of Pittsburgh Medical Center
    1
  • National and Kapodistrian University of Athens
    1