Abstract Background Kai-Xin-San (KXS) has been reported to have a good curative impact on dementia. The purpose of the study was to determine whether KXS might ameliorate cognitive deficits in APP/PS1 mice and to evaluate its neuroprotective mechanism. Methods APP/PS1 mice were employed as an AD animal model; Aβ1–42 and KXS-containing serum were used in HT22 cells. Four different behavioral tests were used to determine the cognitive ability of mice. Nissl staining was utilized to...

Abstract Background Kai-Xin-San (KXS) has been reported to have a good curative impact on dementia. The purpose of the study was to determine whether KXS might ameliorate cognitive deficits in APP/PS1 mice and to evaluate its neuroprotective mechanism. Methods APP/PS1 mice were employed as an AD animal model; Aβ1–42 and KXS-containing serum were used in HT22 cells. Four different behavioral tests were used to determine the cognitive ability of mice. Nissl staining was utilized to...

Data files from " Modulation of deep neural circuits with sonogenetics " Xian et al 2023

Data files from " Modulation of deep neural circuits with sonogenetics " Xian et al 2023

A novel fluorescence and colorimetric dual probe based upon the inner filter effect (IFE) is reported to selectively and sensitively determine alkaline phosphatase (ALP). First, up-conversion nanoparticles (UCNPs) were prepared via a facile hydrothermal method and characterized by transmission electron microscopy (TEM), X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FT-IR), and zeta potential. Under near infrared (NIR) excitation at 980 nm, the prepared nanoparticles emit green light at 541 nm. The absorption band of p-phenylenediamine...

Data files from " Modulation of deep neural circuits with sonogenetics " Xian et al 2023

A novel fluorescence and colorimetric dual probe based upon the inner filter effect (IFE) is reported to selectively and sensitively determine alkaline phosphatase (ALP). First, up-conversion nanoparticles (UCNPs) were prepared via a facile hydrothermal method and characterized by transmission electron microscopy (TEM), X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FT-IR), and zeta potential. Under near infrared (NIR) excitation at 980 nm, the prepared nanoparticles emit green light at 541 nm. The absorption band of p-phenylenediamine...

Additional file 1: Figure S1. The histogram of the number of survival neurons in hippocampal CA1 and CA3 regions of APP/PS1 mice. KXS-H: 10g/kg/day. The experiment data are expressed as means ± SEM. n = 3 in each group. ###P < 0.001 vs. Ctrl group; ∗P < 0.05 vs. APP/PS1 group. Figure S2. The histogram of immunofluorescent about SIRT3 and NLRP3 in the hippocampus of APP/PS1 mice. n = 3 in each group. ###P <...

Additional file 1: Figure S1. The histogram of the number of survival neurons in hippocampal CA1 and CA3 regions of APP/PS1 mice. KXS-H: 10g/kg/day. The experiment data are expressed as means ± SEM. n = 3 in each group. ###P < 0.001 vs. Ctrl group; ∗P < 0.05 vs. APP/PS1 group. Figure S2. The histogram of immunofluorescent about SIRT3 and NLRP3 in the hippocampus of APP/PS1 mice. n = 3 in each group. ###P <...