7 Works

Evolution vers la 3ème dimension pour une meilleure compréhension du microenvironnement immunitaire dans les tumeurs

Laïla Letaïef, Safa Azar, Isabelle Brunet, Hélène Kaplon, Jean-Luc Teillaud & Marie-Caroline Dieu-Nosjean
L’analyse du microenvironnement d’un tissu fournit une manne d’informations quasiment illimitées pour les chercheurs et les cliniciens. Les avancées très récentes des techniques d’immunohistochimie (IHC) et d’immunofluorescence (IF) ont permis de mieux appréhender la complexité du microenvironnement tissulaire notamment dans les cancers. Au travers de plusieurs exemples développés dans les cancers du poumon, les limites de l’IHC/IF ont été repoussées pour mieux répondre à des questions comme : est-ce que le niveau d’organisation in situ...

The search for sexually antagonistic genes: practical insights from studies of local adaptation and statistical genomics

Filip Ruzicka, Ludovic Dutoit, Peter Czuppon, Crispin Y. Jordan, Xiang‐Yi Li, Colin Olito, Homa Papoli Yazdi, Tim Connallon, Erik Svensson & Anna Runemark
Sexually antagonistic (SA) genetic variation—in which alleles favored in one sex are disfavored in the other—is predicted to be common and has been documented in several animal and plant populations, yet we currently know little about its pervasiveness among species or its population genetic basis. Recent applications of genomics in studies of SA genetic variation have highlighted considerable methodological challenges to the identification and characterization of SA genes, raising questions about the feasibility of genomic...

A minimal yet flexible likelihood framework to assess correlated evolution

Abdelkader Behdenna, Maxime Godfroid, Patrice Petot, Joël Pothier, Camille Nous, Amaury Lambert & Guillaume Achaz
An evolutionary process is reflected in the sequence of changes through time of any trait (e.g. morphological, molecular). Yet, a better understanding of evolution would be procured by characterizing correlated evolution, or when two or more evolutionary processes interact. A wide range of parametric methods have previously been proposed to detect correlated evolution but they often require significant computing time as they rely on the estimation of many parameters. Here we propose a minimal likelihood...

Codes and data from: The effect of habitat choice on evolutionary rescue in subdivided populations

Peter Czuppon, François Blanquart, Hildegard Uecker & Florence Débarre
Evolutionary rescue is the process by which a population, in response to an environmental change, successfully avoids extinction through adaptation. In spatially structured environments, dispersal can affect the probability of rescue. Here, we model an environment consisting of patches that degrade one after another, and we investigate the probability of rescue by a mutant adapted to the degraded habitat. We focus on the effects of dispersal and of immigration biases. We find that the probability...

Binding of acetylcholine and other quaternary ammonium cations by sulfonated calixarenes. Crystal structure of a [choline-tetrasulfonated calix[4]arene] complex

Jean-Marie Lehn, Robert Meric, Jean-Pierre Vigneron, Michele Cesario, Jean Guilhem, Claudine Pascard, Zouhair Asfari & Jacques Vicens
(1995). Binding of acetylcholine and other quaternary ammonium cations by sulfonated calixarenes. Crystal structure of a [choline-tetrasulfonated calix[4]arene] complex. Supramolecular Chemistry: Vol. 5, No. 2, pp. 97-103.

Data from: The genomic view of diversification

Julie Marin, Guillaume Achaz, Anton Crombach & Amaury Lambert
The process of species diversification is traditionally summarized by a tree, the species tree, whose reconstruction from molecular data is hindered by frequent conflicts between gene genealogies. Here, we argue that instead of seeing these conflicts as nuisances, we can exploit them to inform the diversification process itself. We adopt a gene-based view of diversification to model the ubiquitous presence of gene flow among diverging lineages, one of the most important processes explaining disagreements among...

Data from: Developmental mechanisms of stripe patterns in rodents

Ricardo Mallarino, Corneliu Henegar, Mercedes Mirasierra, Marie Manceau, Carsten Schradin, Mario Vallejo, Slobodan Beronja, Gregory S. Barsh & Hopi E. Hoekstra
Mammalian colour patterns are among the most recognizable characteristics found in nature and can have a profound impact on fitness. However, little is known about the mechanisms underlying the formation and subsequent evolution of these patterns. Here we show that, in the African striped mouse (Rhabdomys pumilio), periodic dorsal stripes result from underlying differences in melanocyte maturation, which give rise to spatial variation in hair colour. We identify the transcription factor ALX3 as a regulator...

Registration Year

  • 2021
  • 2020
  • 2016

Resource Types

  • Dataset
  • Text


  • Collège de France
  • Sorbonne University
  • Institut National des Sciences Appliquées de Strasbourg
  • Howard Hughes Medical Institute
  • Fred Hutchinson Cancer Research Center
  • University of Neuchâtel
  • Lund University
  • University of Otago
  • University of Edinburgh
  • Monash University