25 Works

Landscape of RNA editing reveals new insights into the dynamic gene regulation of spermatogenesis

Xiaodan Wang, Xiaolong Wu, Zhenshuo Zhu, Hao Li, Tongtong Li, Qun Li, Peng Zhang, Leijie Li, Dongxue Che, Xia Xiao, Tong Liu, Jinlian Hua & Mingzhi Liao
Spermatogenesis is an important physiological process associated with male infertility. As a kind of post-transcriptional regulation, RNA editings (REs) change the genetic information at the mRNA level. But whether there are REs and what’s the role of REs during the process are still unclear. In this study, we integrated published RNA-Seq datasets and established a landscape of RNA REs during the development of mouse spermatogenesis. Totally, 7530 editing sites occurred in 2012 genes among all...

The role of DRP1 in ropivacaine-induced mitochondrial dysfunction and neurotoxicity

Yan Chen, Lili Yan, Yan Zhang & Xianhui Yang
Ropivacaine is a commonly used local anaesthetic, but its side effects remain largely unknown. In the present study, we investigated the side effects of ropivacaine in human neuronal SH-5Y5Y cells. We show that 0.5% and 1% ropivacaine could cause fission-like mitochondrial morphological changes. Ropivacaine exclusively induces mitochondrial fission protein DRP1, generation of ROS and causes mitochondrial dysfunction including decreasing mitochondrial membrane potential, the activity of cytochrome C oxidase and ATP production. The side effects of...

Delivery of mesenchymal stem cells-derived extracellular vesicles with enriched miR-185 inhibits progression of OPMD

Lin Wang, Panpan Yin, Jiaqi Wang, Yuanyuan Wang, Zheng Sun, Yu Zhou & Xiaobing Guan
Oral leukoplakia is one of the most common oral potentially malignant disorders (OPMDs) and its malignant transformation to oral cancer is highly associated with chronic inflammation. Extracellular vesicles (EVs) or exosome-delivered microRNAs modulate inflammatory responses and alleviate irritations that predisposes to cancer. We previously reported that microRNA-185 (miR-185) was significantly decreased in the buccal tissue of patients with oral cancer. In this study, we utilized genetically modified mesenchymal stem cells (MSCs) derived EVs with high...

Sevoflurane suppresses migration and invasion of glioma cells by regulating miR-146b-5p and MMP16

Le Zhang, Jun Wang, Zhijie Fu, YanQiu Ai, Yanrong Li, Ying Wang & Yanping Wang
Glioma is the most common brain tumor with poor prognosis all over the world. Anesthetics have been demonstrated to have important impacts on cell migration and invasion in different cancers. However, the underlying mechanism that allows anesthetics-mediated progression of glioma cells remains elusive. Sevoflurane (Sev), a class of common anesthetics, was used to expose to U87-MG and U251 cells. The expressions of microRNA-146b-5p (miR-146b-5p) and matrix metallopeptidase 16 (MMP16)were measured by quantitative real-time polymerase chain...

Spontaneous formation of tumorigenic hybrids between human omental adipose-derived stromal cells and endometrial cancer cells increased motility and heterogeneity of cancer cells

Mingxia Li, Xiaoping Li, Lijun Zhao, Jingyi Zhou, Yuan Cheng, Bo Xu, Jianliu Wang & Lihui Wei
Recent reports indicate that mesenchymal stem cells (MSCs) can fuse with cancer cells to promote cancer progression. Omental adipose-derived stromal cells (O-ASCs) are similar to MSCs, which could be recruited to the stroma in endometrial cancer. The aim of our study was to investigate whether O-ASCs can fuse with endometrial cancer cells to influence cancer cells biological characteristics. We isolated O-ASCs from patients with endometrial cancer. O-ASCs and endometrial cancer cells were labeled with different...

Spontaneous formation of tumorigenic hybrids between human omental adipose-derived stromal cells and endometrial cancer cells increased motility and heterogeneity of cancer cells.

Mingxia Li, Xiaoping Li, Lijun Zhao, Jingyi Zhou, Yuan Cheng, Bo Xu, Jianliu Wang & Lihui Wei
Recent reports indicate that mesenchymal stem cells (MSCs) can fuse with cancer cells to promote cancer progression. Omental adipose-derived stromal cells (O-ASCs) are similar to MSCs, which could be recruited to the stroma in endometrial cancer. The aim of our study was to investigate whether O-ASCs can fuse with endometrial cancer cells to influence cancer cells biological characteristics We isolated O-ASCs from patients with endometrial cancer. O-ASCs and endometrial cancer cells were labeled with different...

Cadomian crust of Eastern Iran: evidence from the Tapeh Tagh granitic gneisses

Habib Mollai, Rahim Dabiri, Habib Allah Torshizian, Georgia Pe-Piper & Wei Wang
Late Neoproterozoic to Early Cambrian (Cadomian) magmatic rocks are abundant in Iran, but their occurrence in east-central Iran is voluminous. This paper reports, for the first time, on the Cadomian rocks of the eastern Iranian region known as Tapeh Tagh and deals with their geochemistry and uranium-lead (U-Pb) zircon ages. The Tapeh Tagh region contains masses of Cadomian meta-igneous rocks (including various types of granitic gneiss) and overlying meta-sedimentary rocks. The granitic gneisses show tectonic...

Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling

Dan Zhao, Cong Shen, Tingting Gao, Hong Li, Yueshuai Guo, Feng Li, Chenchen Liu, Yuanyuan Liu, Xia Chen, Xi Zhang, Yangyang Wu, Yi Yu, Meng Lin, Yan Yuan, Xiaofang Chen, Xiaoyan Huang, Shenmin Yang, Jun Yu, Jun Zhang & Bo Zheng
Myotubularin related protein 7 (MTMR7), a key member of the MTMR family, depicts phosphatase activity and is involved in myogenesis and tumor growth. We have previously identified MTMR7 in the proteomic profile of mouse spermatogonial stem cell (SSC) maturation and differentiation, implying that MTMR7 is associated with neonatal testicular development. In this study, to further explore the distribution and function of MTMR7 in mouse testis, we studied the effect of Mtmr7 knockdown on neonatal testicular...

Cholesterol depletion sensitizes gallbladder cancer to cisplatin by impairing DNA damage response

Yonglong Zhang, Yanfeng Liu, Jinlin Duan, Hui Wang, Yuchen Zhang, Ke Qiao & Jian Wang
Gallbladder cancer (GBC) is the common malignancy of the bile tract system with extremely poor clinical outcomes, owing to its metastatic property and intrinsic resistance to the first-line drugs. Although it is well-established that cholesterol abnormity contributes to gallstone formation, a leading risk factor for GBC, the link of cholesterol homeostasis with GBC has not been investigated. The present study systematically examined the genes implicated in cholesterol homeostasis, and revealed altered gene expressions of de...

Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling

Dan Zhao, Cong Shen, Tingting Gao, Hong Li, Yueshuai Guo, Feng Li, Chenchen Liu, Yuanyuan Liu, Xia Chen, Xi Zhang, Yangyang Wu, Yi Yu, Meng Lin, Yan Yuan, Xiaofang Chen, Xiaoyan Huang, Shenmin Yang, Jun Yu, Jun Zhang & Bo Zheng
Myotubularin related protein 7 (MTMR7), a key member of the MTMR family, depicts phosphatase activity and is involved in myogenesis and tumor growth. We have previously identified MTMR7 in the proteomic profile of mouse spermatogonial stem cell (SSC) maturation and differentiation, implying that MTMR7 is associated with neonatal testicular development. In this study, to further explore the distribution and function of MTMR7 in mouse testis, we studied the effect of Mtmr7 knockdown on neonatal testicular...

Cadomian crust of Eastern Iran: evidence from the Tapeh Tagh granitic gneisses

Habib Mollai, Rahim Dabiri, Habib Allah Torshizian, Georgia Pe-Piper & Wei Wang
Late Neoproterozoic to Early Cambrian (Cadomian) magmatic rocks are abundant in Iran, but their occurrence in east-central Iran is voluminous. This paper reports, for the first time, on the Cadomian rocks of the eastern Iranian region known as Tapeh Tagh and deals with their geochemistry and uranium-lead (U-Pb) zircon ages. The Tapeh Tagh region contains masses of Cadomian meta-igneous rocks (including various types of granitic gneiss) and overlying meta-sedimentary rocks. The granitic gneisses show tectonic...

MiR-150-5p retards the progression of myocardial fibrosis by targeting EGR1

Jie Shen, Wanhong Xing, Fangqi Gong, Wei Wang, Yufeng Yan, Yiying Zhang, Chunhong Xie & Songling Fu
To investigate the differential expression of microRNA-150-5p (miR-150-5p) and early growth response 1 (EGR1) in myocardial fibrosis (MF) cells, and determine the effect between miR-150-5p and EGR1 on MF. Human MF cells were generated via Trypanosoma cruzi (T. cruzi) infection, a mouse model of MF was generated via angiotensin II. The expression levels of miR-150-5p and EGR1 were detected by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assay. The correlation between miR-150-5p and...

MiR-150-5p retards the progression of myocardial fibrosis by targeting EGR1

Jie Shen, Wanhong Xing, Fangqi Gong, Wei Wang, Yufeng Yan, Yiying Zhang, Chunhong Xie & Songling Fu
To investigate the differential expression of microRNA-150-5p (miR-150-5p) and early growth response 1 (EGR1) in myocardial fibrosis (MF) cells, and determine the effect between miR-150-5p and EGR1 on MF. Human MF cells were generated via Trypanosoma cruzi (T. cruzi) infection, a mouse model of MF was generated via angiotensin II. The expression levels of miR-150-5p and EGR1 were detected by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assay. The correlation between miR-150-5p and...

Delivery of mesenchymal stem cells-derived extracellular vesicles with enriched miR-185 inhibits progression of OPMD

Lin Wang, Panpan Yin, Jiaqi Wang, Yuanyuan Wang, Zheng Sun, Yu Zhou & Xiaobing Guan
Oral leukoplakia is one of the most common oral potentially malignant disorders (OPMDs) and its malignant transformation to oral cancer is highly associated with chronic inflammation. Extracellular vesicles (EVs) or exosome-delivered microRNAs modulate inflammatory responses and alleviate irritations that predisposes to cancer. We previously reported that microRNA-185 (miR-185) was significantly decreased in the buccal tissue of patients with oral cancer. In this study, we utilized genetically modified mesenchymal stem cells (MSCs) derived EVs with high...

The role of DRP1 in ropivacaine-induced mitochondrial dysfunction and neurotoxicity

Yan Chen, Lili Yan, Yan Zhang & Xianhui Yang
Ropivacaine is a commonly used local anaesthetic, but its side effects remain largely unknown. In the present study, we investigated the side effects of ropivacaine in human neuronal SH-5Y5Y cells. We show that 0.5% and 1% ropivacaine could cause fission-like mitochondrial morphological changes. Ropivacaine exclusively induces mitochondrial fission protein DRP1, generation of ROS and causes mitochondrial dysfunction including decreasing mitochondrial membrane potential, the activity of cytochrome C oxidase and ATP production. The side effects of...

Spontaneous formation of tumorigenic hybrids between human omental adipose-derived stromal cells and endometrial cancer cells increased motility and heterogeneity of cancer cells

Mingxia Li, Xiaoping Li, Lijun Zhao, Jingyi Zhou, Yuan Cheng, Bo Xu, Jianliu Wang & Lihui Wei
Recent reports indicate that mesenchymal stem cells (MSCs) can fuse with cancer cells to promote cancer progression. Omental adipose-derived stromal cells (O-ASCs) are similar to MSCs, which could be recruited to the stroma in endometrial cancer. The aim of our study was to investigate whether O-ASCs can fuse with endometrial cancer cells to influence cancer cells biological characteristics. We isolated O-ASCs from patients with endometrial cancer. O-ASCs and endometrial cancer cells were labeled with different...

High-flow nasal cannula versus nasal continuous positive airway pressure for respiratory support in preterm infants: a meta-analysis of randomized controlled trials

Hui Hong, Xiao-xia Li, Jing Li & Zhi-qun Zhang
Background: As a noninvasive respiratory support mode, high-flow nasal cannula (HFNC) is widely used in preterm infants at neonatal care units. HFNC is often used as an alternative to nasal continuous positive airway pressure (NCPAP) for initial or post-extubation respiratory support. The purpose of this meta-analysis is to evaluate and compare the efficacy and safety of HFNC and NCPAP for respiratory support in preterm infants. Methods: We searched PubMed, Web of Science, Embase, Cochrane Library,...

RETRACTED ARTICLE: MicroRNA-3194-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by decreasing Wnt/β-catenin signaling through targeting BCL9

Bowen Yao, Yazhao Li, Liang Wang, Tianxiang Chen, Yongshen Niu, Qingguang Liu & Zhikui Liu
We, the Editors and Publisher of the journal Artificial Cells, Nanomedicine, and Biotechnology, have retracted the following article: Bowen Yao, Yazhao Li, Liang Wang, Tianxiang Chen, Yongshen Niu, Qingguang Liu & Zhikui Liu (2019) MicroRNA-3194-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by decreasing Wnt/β-catenin signaling through targeting BCL9. Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 3885–3895, DOI: 10.1080/21691401.2019.1670190 Since publication, concerns have been raised about the integrity of the data in the article. In...

MicroRNA-3194-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by decreasing Wnt/β-catenin signaling through targeting BCL9

Bowen Yao, Yazhao Li, Liang Wang, Tianxiang Chen, Yongshen Niu, Qingguang Liu & Zhikui Liu
Local and systemic metastasis of hepatocellular carcinoma (HCC) causes the poor prognosis and increasing evidence confirms that aberrant miRNAs were involved in cancer progression. However, the expression and mechanisms of a specific miR-3194-3p in HCC remains unknown. In this research, we demonstrated that miR-3194-3p, significantly down-regulated in HCC tissues and cell lines, was associated with metastasis and recurrence of HCC. Notably, gain- and loss-of-function assays demonstrated that miR-3194-3p inhibited the migration, invasion and epithelial-mesenchymal transition...

The assessment of different vegetation indices for spatial disaggregating of thermal imagery over the humid agricultural region

Kai Liu, Shudong Wang, Xueke Li, Yao Li, Bo Zhang & Ruiting Zhai
Land surface temperature (LST) plays a significant role in surface water circulation and energy balance at both global and regional scales. Thermal disaggregation technique, which relies on vegetation indices, has been widely used due to its advantage in producing relatively high resolution LST data. However, the spatial enhancement of satellite LST using soil moisture delineated vegetation indices has not gained enough attention. Here we compared the performances of temperature vegetation dryness index (TVDI), normalized difference...

Landscape of RNA editing reveals new insights into the dynamic gene regulation of spermatogenesis

Xiaodan Wang, Xiaolong Wu, Zhenshuo Zhu, Hao Li, Tongtong Li, Qun Li, Peng Zhang, Leijie Li, Dongxue Che, Xia Xiao, Tong Liu, Jinlian Hua & Mingzhi Liao
Spermatogenesis is an important physiological process associated with male infertility. As a kind of post-transcriptional regulation, RNA editings (REs) change the genetic information at the mRNA level. But whether there are REs and what’s the role of REs during the process are still unclear. In this study, we integrated published RNA-Seq datasets and established a landscape of RNA REs during the development of mouse spermatogenesis. Totally, 7530 editing sites occurred in 2012 genes among all...

High-flow nasal cannula versus nasal continuous positive airway pressure for respiratory support in preterm infants: a meta-analysis of randomized controlled trials

Hui Hong, Xiao-xia Li, Jing Li & Zhi-qun Zhang
Background: As a noninvasive respiratory support mode, high-flow nasal cannula (HFNC) is widely used in preterm infants at neonatal care units. HFNC is often used as an alternative to nasal continuous positive airway pressure (NCPAP) for initial or post-extubation respiratory support. The purpose of this meta-analysis is to evaluate and compare the efficacy and safety of HFNC and NCPAP for respiratory support in preterm infants. Methods: We searched PubMed, Web of Science, Embase, Cochrane Library,...

RETRACTED ARTICLE: Sevoflurane suppresses migration and invasion of glioma cells by regulating miR-146b-5p and MMP16

Le Zhang, Jun Wang, Zhijie Fu, YanQiu Ai, Yanrong Li, Ying Wang & Yanping Wang
We, the Editors and Publisher of the journal Artificial Cells, Nanomedicine, and Biotechnology, have retracted the following article: Le Zhang, Jun Wang, Zhijie Fu, YanQiu Ai, Yanrong Li, Ying Wang & Yanping Wang (2019) Sevoflurane suppresses migration and invasion of glioma cells by regulating miR-146b-5p and MMP16. Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 3306–3314, DOI: 10.1080/21691401.2019.1648282 Since publication, concerns have been raised about the integrity of the data in the article. When approached for an...

miR-29c-3p inhibits autophagy and cisplatin resistance in ovarian cancer by regulating FOXP1/ATG14 pathway

Zhenhua Hu, Mingbo Cai, Ying Zhang, Lingling Tao & Ruixia Guo
Autophagy, characterized by the elevator of autophagy-related gene 14 (ATG14) and the dysregulation of autophagy-related proteins, contributes to the cisplatin (DDP) resistance in ovarian cancer. Forkhead box protein P1 (FOXP1), which is a well-defined transcription factor, is reported to have the oncogenic effect on ovarian cancer. This study aims to identify the effect of miR-29c-3p/FOXP1/ATG14 pathway in regulating autophagy and DDP resistance in ovarian cancer. The expressions of miR-29c-3p, FOXP1, ATG14 and autophagy-related proteins were...

The assessment of different vegetation indices for spatial disaggregating of thermal imagery over the humid agricultural region

Kai Liu, Shudong Wang, Xueke Li, Yao Li, Bo Zhang & Ruiting Zhai
Land surface temperature (LST) plays a significant role in surface water circulation and energy balance at both global and regional scales. Thermal disaggregation technique, which relies on vegetation indices, has been widely used due to its advantage in producing relatively high resolution LST data. However, the spatial enhancement of satellite LST using soil moisture delineated vegetation indices has not gained enough attention. Here we compared the performances of temperature vegetation dryness index (TVDI), normalized difference...

Registration Year

  • 2019
    25

Resource Types

  • Dataset
    14
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    10
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    1

Affiliations

  • Xuzhou Medical College
    25
  • Shanghai Jiao Tong University
    22
  • Fudan University
    20
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    20
  • Zhejiang University
    19
  • Huazhong University of Science and Technology
    19
  • Sichuan University
    19
  • Sun Yat-sen University
    16
  • University of Chinese Academy of Sciences
    15
  • Southern Medical University
    14