Experimental characterization

Additional file 1: Fig. S1. The mRNA levels of candidate genes in different molecular subtypes of breast cancer. ER/PR+ (ER/PR+ and HER−, n = 685), HER2+ (n = 168), and TNBC (n = 177). TCGA BRCA ER, PR, and HER2 status were retrieved from Thennavan et al. [21].

Additional file 1: Figure S1. Scatterplot of polymyxin B AUCss,24h versus dosage. AUCss,24h, the area under the plasma concentration-time curve across 24 hours at steady state. Figure S2. Scatterplot of polymyxin B AUCss,24h (a) and C0h (b) stratified for different stages of acute kidney injury. AUCss,24h, the area under the plasma concentration-time curve across 24 hours at steady state; C0h, trough concentration. Figure S3. Kaplan-Meier estimates of survival to 30 days after administration of polymyxin...

Additional file 11: Table S4. Taxa associated with TMA metabolism using the Mann-Whitney U-test.

Additional file 12: Table S5. Taxa associated with TMA metabolism using LEfSe analysis.

Additional file 1. Preparation for iTRAQ quantitative proteomics study.

Additional file 3. The Gaussian fitting curve of log2 ratio of the intensities of two replicates of 20/0 (A), 80/0 (B) and 160/0 (C). The red and blue curves represent the experimental and Gaussian fitting curve, respectively.

The detailed information of sampling stations, the carbon, nitrogen, and amino acids levels in DOM and POM, as well as other parameters including temperature, salinity, nutrients, chlorophyll-a, and biological parameters (heterotrophic bacteria, Synechococcus, and picoeukaryotes) are dispalyed in this dataset.

Angle resolved photoemission spectroscopy with nanometer-scale spatial resolution (Nano-ARPES) is a powerful tool for the investigation of electronic structure of materials and its spatial distribution. In order to target the area of interest in Nano-ARPES measurements effectively, optical microscopy can be used to provide real space optical images as reference. In this work, a new type of optical microscopy for Nano APRES spectrometer with a large tilt angle of ~30 degrees and long focus length...

Supplementary materials

Abstract Background Esophageal carcinoma is the highly lethal cancer in the world, predominantly in some areas of East Asia. We previously reported that overexpression of cytoskeleton regulator Wiskott-Aldrich syndrome protein and SCAR Homolog (WASH) associates with poor prognosis of patients with esophageal squamous cell carcinoma (ESCC). However, the molecular mechanism and clinical significance involved in WASH overexpression have not been fully elucidated. Methods Bioinformatics analysis and luciferase reporter assay were used to predict and validate...

Additional file 4: Appendix 3. WinBUGS Code for Network Meta-Analyses.

Configuration of simulation setup

We demonstrate that reflectionless propagation of electromagnetic waves between two different materials can be achieved by designing an intermediate temporal medium, which can work in an ultra-wide frequency band. Such a temporal medium is designed with consideration of a multi-stage variation of the material’s permittivity in the time domain. The multi-stage temporal permittivity is formed by a cascaded quarter-wave temporal coating, which is an extension of the antireflection temporal coating by Pacheco-Peña et al [[1]...

Abstract Background Acetaminophen is commonly recommended for the early analgesia of osteoarthritis. However, the molecular mechanism by which it acts remains unknown. The aim of this study is to investigate the effect of acetaminophen on inflammation and extracellular matrix degradation in human chondrocytes, and the possible molecular mechanisms involved in its effect. Methods The normal chondrocyte cell line C28/I2 was treated with interleukin-1β to mimic the inflammatory state. Acetaminophen and the methylation inhibitor (cycloleucine) were...

Abstract Background Acetaminophen is commonly recommended for the early analgesia of osteoarthritis. However, the molecular mechanism by which it acts remains unknown. The aim of this study is to investigate the effect of acetaminophen on inflammation and extracellular matrix degradation in human chondrocytes, and the possible molecular mechanisms involved in its effect. Methods The normal chondrocyte cell line C28/I2 was treated with interleukin-1β to mimic the inflammatory state. Acetaminophen and the methylation inhibitor (cycloleucine) were...

Additional file 1: Supplementary Figure 1. MMP-13 levels in the medium of IL-1β-induced C28/I2 cells detected by ELISA.

Additional file 2: Supplementary Figure 2. The original versions of Fig. 1B. Supplementary Figure 3. The original versions of Fig. 2D. Supplementary Figure 4. The original versions of Fig. 3A. Supplementary Figure 5. The original versions of Fig. 3E.

Abstract Abdominal aortic aneurysm (AAA) represents the serious vascular degenerative disorder, which causes high incidence and mortality. Alpha-ketoglutarate (AKG), a crucial metabolite in the tricarboxylic acid (TCA) cycle, has been reported to exert significant actions on the oxidative stress and inflammation. However, its role in AAA still remains elusive. Herein, we examined the effects of AKG on the formation of AAA. The study established an elastase-induced mouse abdominal aortic aneurysms model as well as a...

The establishment of effective vascularization represents a key challenge in regenerative medicine. Adequate sources of vascular cells and intact vessel fragments have not yet been explored. We herein examined the potential application of microvessels induced from hiPSCs for rapid angiogenesis and tissue regeneration. Microvessels were generated from human pluripotent stem cells (iMVs) under a defined induction protocol and compared with human adipose tissue-derived microvessels (ad-MVs) to illustrate the similarity and differences of the alternative source....

Background: Methylated SEPT9 (mSEPT9) has a role in the occurrence and development of hepatocellular carcinoma (HCC). Here, we studied the significance of plasma mSEPT9 for predicting prognosis-associated pathological parameters in patients with HCC. Methods: We retrospectively analyzed data from 205 subjects, including 111 HCC patients, 53 patients with at-risk liver disease (ARD) and 41 healthy donors (HDs). Analysis of plasma mSEPT9 was performed using methylation-specific polymerase chain reaction. Levels of mSEPT9 among different groups were...

Background: Methylated SEPT9 (mSEPT9) has a role in the occurrence and development of hepatocellular carcinoma (HCC). Here, we studied the significance of plasma mSEPT9 for predicting prognosis-associated pathological parameters in patients with HCC. Methods: We retrospectively analyzed data from 205 subjects, including 111 HCC patients, 53 patients with at-risk liver disease (ARD) and 41 healthy donors (HDs). Analysis of plasma mSEPT9 was performed using methylation-specific polymerase chain reaction. Levels of mSEPT9 among different groups were...

Supplemental material, sj-doc-3-tct-10.1177_15330338221123634 for Ixazomib Combined With Autologous Stem Cell Transplantation for POEMS Syndrome: A Case Report and Meta-Analysis by Ji Ma, Xiaoyue Wang, Hui Lu, Zhihao Liang and Liang Wang in Technology in Cancer Research & Treatment

Supplemental material, sj-docx-4-taj-10.1177_20406223221143245 for Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis by Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang and Yunshan Cao in Therapeutic Advances in Chronic Disease

Supplemental material, sj-docx-7-taj-10.1177_20406223221143245 for Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis by Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang and Yunshan Cao in Therapeutic Advances in Chronic Disease