Abstract Background There are debates in acupuncture related systematic reviews and meta-analyses on whether searching Chinese databases to get more Chinese-language studies may increase the risk of bias and overestimate the effect size, and whether the treatment effects of acupuncture differ between Chinese and non-Chinese populations. Methods In this meta-epidemiological study, we searched the Cochrane library from its inception until December 2021, and identified systematic reviews and meta-analyses with acupuncture as one of the interventions....

Additional file 1: Table S1. Factors and levels of Plackett-Burman experiment. Table S2. Factors and levels of Central Composite design. Table S3. Plackett-Burma test design and results. Table S4. The variance analysis of Plackett-Burman test. Table S5. The design and results of steepest ascent experiment. Table S6. CCD design and results. Table S7. The variance analysis of experiment. Figure S1. The alkaline protease and process pH during the fermentation of different initial medium pH.

Abstract Alkaline protease is widely used in the food, detergent, and pharmaceutical industries because of its comparatively great hydrolysis ability and alkali tolerance. To improve the ability of the recombinant Bacillus licheniformis to produce alkaline protease, single-factor experiments and response surface methodology (RSM) were utilized to determine and develop optimal culture conditions. The results showed that three factors (corn starch content, soybean meal content, and initial medium pH) had significant effects on alkaline protease production...

Abstract Background Increasing evidence indicates that radiotherapy (RT) has synergistic inhibitory efficiency with immunotherapy agents in multiple cancers and enhances abscopal effects by regulating the innate immune response, which was further investigated in this study. Neutrophils are recruited in radiated tumors. Therefore, neutrophil membrane-coated nanoparticles potentially deliver R837 (Toll-like receptor 7 agonist) to radiated tumors. Methods A novel nanoparticle R837@PLGA@Neu was prepared by initially assembling PLGA (poly (lactic-co-glycolic acid)) with R837 (TLR7 agonist) into R837@PLGA...

Abstract Purpose Hepatocellular carcinoma (HCC) is a kind of primary liver cancer. It is a common malignant tumor of digestive system that is difficult to predict the prognosis of patients. As an important epigenetic modification, N7 methyl guanosine (m7G) is indispensable in gene regulation. This regulation may affect the development and occurrence of cancer. However, the prognosis of long non coding RNAs (lncRNAs) in HCC is limited, especially how m7G-related lncRNAs regulate the development of...

Additional file 2: Table S2. The differentially expressed m7G-related genes between HCC and normal samples.

Details about our method and theory

Decoy-state measurement-device-independent quantum key distribution (MDI-QKD) has been regarded as one of the most promising protocols since it is physically immune to all fatal detection-side attacks. However, the loopholes in the source side still open side-channels to eavesdroppers. Previous works have indicated that some sophisticated attacks could be performed if the decoy states are inaccurate, but more details about the ``sophisticated attack'' are still absent. In this work, we proposed a threatening hacking strategy accompanying...

Purpose: To translate and cross-culturally adapt the anterior cruciate ligament-return to sport after injury (ACL-RSI) into simplified Chinese [ACL-RSI (Cn)]. Method: In this diagnostic study, the translation, cross-culturally adaptation, and validation of the ACL-RSI was performed according to international guidelines. A total of 112 patients with ACL reconstruction participated in this study. All were capable of competitive sports before the injury and completed the Knee Injury and Osteoarthritis Outcome (KOOS), the International Knee Documentation Committee...

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis. Therefore, there is an urgent need to identify prognostic markers to improve current treatment and therapeutic strategies. The transcriptional factor ZNF503 has been reported to promote aggressive breast cancer development through the down-regulation of GATA3 expression and has been identified as a candidate predictive marker. In this study, we explored whether ZNF503 and GATA3 could serve as prognostic markers independently or in...

Supplemental material, sj-xlsx-1-cat-10.1177_10760296231167849 for Low MHR Is Associated with Hemorrhagic Transformation in Acute Large Artery Atherosclerosis Ischemic Stroke Patients with Intravenous Thrombolysis by Delong Meng, MM, Yan Li, MM, Ting Ju, MM, Wei Huo, MD, and Mingfei Wang, MD in Clinical and Applied Thrombosis/Hemostasis

Additional file 1: Figure S1. The workflow of KuA in treatment of OP. Figure S2. GO enrichment analysis among target genes. (A) Cell type signature. (B) Disgenet analysis. (C) Trrust analysis. (D) Pagenbase analysis. (E) Transcription factor. Figure S3. KuA improve the mechanical properties and inflammation level in OVX mice. (A) Stiffness of tibia. (B) Displacement of tibia. (C) Energy absorption. (D) serum IL-6. (E)serum CRP. (F) serum TNF-α. (G) serum IL-1b. (H) Principal genetic...

Additional file 3. Search strategy used for PUBMED, Web of Science, and EMBASE.

Additional file 4. Extraction form utilitzed by authors for O2 only studies and O2 with non-O2 studies.

The short-form 6-dimension (SF-6D) is a preference-based measure designed to calculate quality-adjusted life-year (QALY). Preference-based measures are standardized multidimensional health state classifications with preference or utility weights elicited from a sample of the population. There is a concern that valuations may differ between countries because of differences in culture, thus invalidating the use of values obtained from one country to another. To conduct a systematic review of elicitation methods and modeling strategies in SF-6D studies...

The short-form 6-dimension (SF-6D) is a preference-based measure designed to calculate quality-adjusted life-year (QALY). Preference-based measures are standardized multidimensional health state classifications with preference or utility weights elicited from a sample of the population. There is a concern that valuations may differ between countries because of differences in culture, thus invalidating the use of values obtained from one country to another. To conduct a systematic review of elicitation methods and modelling strategies in SF-6D studies...

Supplemental material, sj-jpg-1-tam-10.1177_17588359231167818 for Circulating tumor cells dynamics during chemotherapy predict survival and response in advanced non-small-cell lung cancer patients by Zhen Wang, Xu-Chao Zhang, Wei-Neng Feng, Li Zhang, Xiao-Qing Liu, Wei-Bang Guo, Yan-Ming Deng, Qing-Feng Zou, Jin-Ji Yang, Qing Zhou, Bin-Chao Wang, Hua-Jun Chen, Hai-Yan Tu, Hong-Hong Yan and Yi-Long Wu in Therapeutic Advances in Medical Oncology

Supplemental material, sj-docx-5-tam-10.1177_17588359231167818 for Circulating tumor cells dynamics during chemotherapy predict survival and response in advanced non-small-cell lung cancer patients by Zhen Wang, Xu-Chao Zhang, Wei-Neng Feng, Li Zhang, Xiao-Qing Liu, Wei-Bang Guo, Yan-Ming Deng, Qing-Feng Zou, Jin-Ji Yang, Qing Zhou, Bin-Chao Wang, Hua-Jun Chen, Hai-Yan Tu, Hong-Hong Yan and Yi-Long Wu in Therapeutic Advances in Medical Oncology

Background:Circulating tumor cells (CTCs) are prognostic biomarker in non-small-cell lung cancer (NSCLC). CTCs could also be used as predictor of efficacy of systemic treatments in advanced NSCLC.Objectives:We described the dynamic changes of CTCs during first-line platinum-based chemotherapy in advanced NSCLC and clarified the correlation between CTC counts and efficacy of chemotherapy.Design:Chemotherapy is administered and blood specimens are collected at four time points from baseline to disease progression for CTC detection.Methods:This multicenter prospective study enrolled patients...

Additional file 2: Figure S1. The survival curves of 154 patients with pT1b esophageal squamous cellcarcinoma stratified by the count of D2-40-LI of one representative paraffinblock (RD2-40-LI).

Additional file 2. Table S1: Sample information of WGBS data.

Additional file 1. Fig. S1: The refUMRs provide a better definition of hypermethylated regions in IDH mutant gliomas. Fig. S2: Partial hyper possess distinct features compared with flanking UMRs. Fig. S3: Chromatin features of fhUMRs and phUMRs. Fig. S4: GO and KEGG functional annotation of phUMR and fhUMR related genes. Fig. S5: Transcriptional tendency of phUMR and fhUMR genes in DKFZ. Fig. S6: Cell type enrichment analysis of phUMRs related genes. Fig. S7: Heatmaps of...

Additional file 3. Table S2: The genomic context of phUMRs and fhUMRs.

Abstract Background IDH1/2 hotspot mutations are well known to drive oncogenic mutations in gliomas and are well-defined in the WHO 2021 classification of central nervous system tumors. Specifically, IDH mutations lead to aberrant hypermethylation of under-methylated regions (UMRs) in normal tissues through the disruption of TET enzymes. However, the chromatin reprogramming and transcriptional changes induced by IDH-related hypermethylation in gliomas remain unclear. Results Here, we have developed a precise computational framework based on Hidden Markov...

Additional file 2: Figure S2. Effect of 3 mM Zn2+ on calcium signal transduction related gene transcription levels in RUT-C30 strain. Transcriptional levels of cam (a), cna1 (b), and crz1 (c) of the RUT-C30 strain were detected after culturing in liquid MM for 36, 48 or 60 h containing 0 or 3 mM Zn2+ with 1% (w/v) Avicel as the sole carbon source. The final values are presented as the mean±standard deviation (SD) of three...