Additional file 1.

Supplementary Material 1: TABLE S1: Descriptions of socio-demographic characteristics, CM, PMPU and depression and anxiety symptoms characteristics among college student. TABLE S2: Outcomes (means, ranges, and correlations) of the subscales of the CTQ-SF among the college students. TABLE S3: Full review of multinominal logistic regressions of independent effects between CM and depression and anxiety. TABLE S4: Full review of multinominal logistic regressions of independent effects between PMPU and depression and anxiety. TABLE S5: Full review...

Additional file 2: Table S2. Table of RNA-seq data after Bacillomycin D-C16 treatment versus control at time 12 h.

Supplementary Material 1

Supplementary figures 1 and 2 Supplementary tables Supplementary materials - GAPDH CT value

Supplementary figures 1 and 2 Supplementary tables Supplementary materials - GAPDH CT value

Background:There is evidence supporting the association between Helicobacter pylori infection and colorectal cancer (CRC), but whether H. pylori eradication reduces the risk of CRC is still unknown.Objectives:To compare the incidence of CRC in subjects who had received H. pylori eradication therapy with general population.Design:A population-based retrospective cohort study.Methods:This study included all H. pylori-infected subjects who had received their first course of clarithromycin-containing triple therapy in 2003–2015 in Hong Kong. We compared the observed incidences of...

Abstract Background There is insufficient evidence for the ability of vitamin K2 to improve type 2 diabetes mellitus symptoms by regulating gut microbial composition. Herein, we aimed to demonstrate the key role of the gut microbiota in the improvement of impaired glycemic homeostasis and insulin sensitivity by vitamin K2 intervention. Methods We first performed a 6-month RCT on 60 T2DM participants with or without MK-7 (a natural form of vitamin K2) intervention. In addition, we...

Abstract Background Lipid metabolism disorder during pregnancy has been reported in women with gestational diabetes mellitus (GDM). However, controversy remains regarding the relationship between maternal changes in lipid profiles and perinatal outcomes. This study investigated the association between maternal lipid levels and adverse perinatal outcomes in women with GDM and non-GDM. Methods In total, 1632 pregnant women with GDM and 9067 women with non-GDM who delivered between 2011–2021 were enrolled in this study. Serum samples...

Additional file 3: Figure S3. The time course for measurement of ECAR in C2C12 cells treated with or without glucosamine and/or NaB. The ECAR was measured under baseline conditions and after glucose, oligomycin and 2-Deoxy-D-glucoseinjection, as indicated by the arrowheads.Glycolysis.Glycolytic capacity. ECAR as calculated from the bioenergetic analysis. Data were normalized to protein concentration units per well prior to statistical analysis. Data are the means ± SEMs. The NaB effect was analysed by ANOVA, *p<0.05,...

Additional file 4: Figure S4. Confocal microscopy analyses in C2C12 cells with GLcN or NaB treatment.Mean fluorescence intensity of ERα.Mean fluorescence intensity of AMPK. Data are the means ± SEMs. The NaB effect was analysed by ANOVA, *p<0.05, **p<0.01, ***p<0.001.

Additional file 5: Table S1. qRT-PCR primer sequences

Abstract The higher prevalence of metabolic syndrome (MetS) in women after menopause is associated with a decrease in circulating 17β-oestradiol. To explore novel treatments for MetS in women with oestrogen deficiency, we studied the effect of exogenous butyrate on diet-induced obesity and metabolic dysfunctions using ovariectomized (OVX) mice as a menopause model. Oral administration of sodium butyrate (NaB) reduced the body fat content and blood lipids, increased whole-body energy expenditure, and improved insulin sensitivity. Additionally,...

Abstract Background Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of chemotherapy with poorly understood mechanisms and few treatments. High-mobility group box 1 (HMGB1)-induced neuroinflammation is the main cause of CIPN. Here, we aimed to illustrate the role of the macrophage scavenger receptor A1 (SR-A1) in HMGB1 clearance and CIPN resolution. Methods Oxaliplatin (L-OHP) was used to establish a CIPN model. Recombinant HMGB1 (rHMGB1) (his tag) was used to evaluate the phagocytosis of HMGB1...

The utilization of DMSO or Ph2SO/(COBr)2 or (COCl)2 for the bromination or chlorination of arenes has been explored. Notably, monobromination of activated arenes can be achieved with high regioselectivity using the combination of dimethyl sulfoxide and oxalyl bromide. Bromodimethylsulfonium bromide generated in situ was proposed to be the active species for bromination. In contrast, the practicality of chlorination of arenes with DMSO or Ph2SO/(COCl)2 is limited due to production of the formation of by-products such...

The utilization of DMSO or Ph2SO/(COBr)2 or (COCl)2 for the bromination or chlorination of arenes has been explored. Notably, monobromination of activated arenes can be achieved with high regioselectivity using the combination of dimethyl sulfoxide and oxalyl bromide. Bromodimethylsulfonium bromide generated in situ was proposed to be the active species for bromination. In contrast, the practicality of chlorination of arenes with DMSO or Ph2SO/(COCl)2 is limited due to production of the formation of by-products such...

Additional file 1: Supplementary Table 1. Kendall’s tau B of the questionnaire survey based on the five-point Likert scale. Supplementary Table 2. A five-point Likert scale questionnaire was used to collect the feedback from dental students (n=72)

Additional file 2. Table S1: Sample information of WGBS data.

Additional file 1. Fig. S1: The refUMRs provide a better definition of hypermethylated regions in IDH mutant gliomas. Fig. S2: Partial hyper possess distinct features compared with flanking UMRs. Fig. S3: Chromatin features of fhUMRs and phUMRs. Fig. S4: GO and KEGG functional annotation of phUMR and fhUMR related genes. Fig. S5: Transcriptional tendency of phUMR and fhUMR genes in DKFZ. Fig. S6: Cell type enrichment analysis of phUMRs related genes. Fig. S7: Heatmaps of...

Additional file 3. Table S2: The genomic context of phUMRs and fhUMRs.

Abstract Background IDH1/2 hotspot mutations are well known to drive oncogenic mutations in gliomas and are well-defined in the WHO 2021 classification of central nervous system tumors. Specifically, IDH mutations lead to aberrant hypermethylation of under-methylated regions (UMRs) in normal tissues through the disruption of TET enzymes. However, the chromatin reprogramming and transcriptional changes induced by IDH-related hypermethylation in gliomas remain unclear. Results Here, we have developed a precise computational framework based on Hidden Markov...

Additional file 2: Figure S2. Effect of 3 mM Zn2+ on calcium signal transduction related gene transcription levels in RUT-C30 strain. Transcriptional levels of cam (a), cna1 (b), and crz1 (c) of the RUT-C30 strain were detected after culturing in liquid MM for 36, 48 or 60 h containing 0 or 3 mM Zn2+ with 1% (w/v) Avicel as the sole carbon source. The final values are presented as the mean±standard deviation (SD) of three...

Additional file 1: Figure S1. 1H-NMR (600 MHz) spectrum of R5H3 (A) and Stearyl-H3R5 (B).

Additional file 3: Figure S3. Viability of human skin squamous cell carcinoma (SCL-1) cells incubated for 48 h with blank cell-penetrating peptide modified transfersomes with components of soybean phospholipid and sodium cholate hydrate (STFs-CPP) and cell-penetrating peptide modified transfersomes with components of 1,2-dioleoyl-3-trimethylammonium-propane and sodium cholate hydrate (DTFs-CPP) without lycorine (LR).

Additional file 6: Figure S6. Average tumor weight of mice in each group after 14 days of treatment. *p < 0.05, **p < 0.01, and ***p < 0.001.