Iron oxide nanoparticles (IONPs) are mostly intended to be administrated intravenously, understanding the interaction of IONPs with vascular endothelial cells is extremely crucial for developing safe application regimes of IONPs. In this work, interactions of three kinds of IONPs to endothelial cells were investigated both in human umbilical vein endothelial cells (HUVECs) and in healthy mice. Both meso-2,3-dimercaptosuccinic acid (DMSA) coated Fe3O4 NPs (DMSA-Fe3O4 NPs) and DMSA-Fe2O3 NPs induced cell growth inhibition, while polyglucose sorbitol...

Prolonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 105 genome copies per ml plasma, SIVhi) but...

Multimode interference (MMI) based power splitters are fundamental building blocks for integrated photonic devices consisting of interferometer structure. In order to forestall the ‘capacity crunch’ in optical communications, integrated devices capable of operating in multiple spectral bands (e.g., conventional telecom window and the emerging 2 µm waveband) have since been proposed and are attracting increasing interest. Here we demonstrate for the first time, to the best of our knowledge, the realization of a dual-band MMI-based...

supplementary material updated

We propose and theoretically investigate the coupled concentric ring resonators on a thickness-constrained GaP on Insulator (GaP-OI) integrated photonic platform. Anomalous dispersion is fulfilled by mode hybridization in the coupled structure on a 200 nm thick GaP-OI resonator which originally only exhibits normal dispersion. The anomalous dispersion profile for the anti-symmetric mode is flattened and broadened in favor of Kerr frequency comb generation by optimizing the waveguide width and the coupling gap size synergistically. We...

Lonicera caerulea var. edulis, known as “blue honeysuckle” or “Haskap,” is a deciduous shrub that belongs to the Caprifoliaceae family. Characterized by the high cold hardiness and high quality of fruit, it has become a novel cash crop in cold regions worldwide. The lack of available chloroplast (cp) genome information limits studies of its molecular breeding and phylogeny. Here, the complete cp genome of Lonicera caerulea var. edulis was assembled and characterized for the first...

Juglans mandshurica Maxim., 1856 is a second-class, protected, rare tree species of high economic and ecological value. We elucidated the complete mitochondrial (mt) genome of J. mandshurica using the Illumina Novaseq 6000 and Nanopore platforms. The complete sequences of 558,032 and 161,386 bp had an overall GC content of 45.0% and 45.3%, respectively, and 61 genes could be annotated, including 38 protein-coding, 20 tRNA, and 3 rRNA genes. The high-quality J. mandshurica mt genomic sequences...

Lonicera caerulea var. edulis, known as “blue honeysuckle” or “Haskap,” is a deciduous shrub that belongs to the Caprifoliaceae family. Characterized by the high cold hardiness and high quality of fruit, it has become a novel cash crop in cold regions worldwide. The lack of available chloroplast (cp) genome information limits studies of its molecular breeding and phylogeny. Here, the complete cp genome of Lonicera caerulea var. edulis was assembled and characterized for the first...

Supplementary figure 1 Supplementary tables 1-6

Particulate matter with an aerodynamic diameter ≤2.5 μm (PM2.5) is a public health risk. We investigate PM2.5 on metabolites in cardiomyocytes and the influence of vitamin C on PM2.5 toxicity. For 24 hours, H9C2 were exposed to various concentrations of PM2.5 (0, 100, 200, 400, 800 μg/ml), after which the levels of reactive oxygen species (ROS) and cell viability were measured using the cell counting kit-8 (CCK-8) and 2′,7′-dichlorofluoresceindiacetate (DCFH2-DA), respectively. H9C2 were treated with...

Particulate matter with an aerodynamic diameter ≤2.5 μm (PM2.5) is a public health risk. We investigate PM2.5 on metabolites in cardiomyocytes and the influence of vitamin C on PM2.5 toxicity. For 24 hours, H9C2 were exposed to various concentrations of PM2.5 (0, 100, 200, 400, 800 μg/ml), after which the levels of reactive oxygen species (ROS) and cell viability were measured using the cell counting kit-8 (CCK-8) and 2′,7′-dichlorofluoresceindiacetate (DCFH2-DA), respectively. H9C2 were treated with...

Supplemental material, sj-docx-1-oed-10.1177_25158414221139002 for A medication-wide association study to identify medications associated with incident clinically significant diabetic retinopathy by Ruilin Xiong, Wei Wang, Xianwen Shang, Yixiong Yuan, Yifan Chen, Lei Zhang, Katerina V Kiburg, Zhuoting Zhu and Mingguang He in Therapeutic Advances in Ophthalmology

We built a comprehensive dataset of the arboviruses and arthropod-specific viruses by curating worldwide available data from Arbovirus Catalog, Section VIII-F of the Biosafety in Microbiological and Biomedical Laboratories 6th edition, Virus Metadata Resource of International Committee on Taxonomy of Viruses, and GenBank. This dataset includes a complete information on viral taxonomy, biological characteristics, vectors and vertebrate hosts, distribution, recommended biosafety levels, genome segment, and nucleotide/amino acid sequences, which will facilitate research by scientists/researchers of...

This is the dataset for paper "Overestimated nitrogen loss from denitrification for natural terrestrial ecosystems in CMIP6 Earth System Models" authored by Feng et al.
The dataset contains six .nc files, and each file contains soil_N15, fgas, and N loss and their quantiles derived with different combinations of N weathering, N depostion and BNF.
Figure1_data.nc is the data for Figure 1 in the main.

Soil d15N and isotope benchmarking based fdenit and N loss

soil d15N and isotope benchmarking based fdenit and N loss

We built a comprehensive dataset of the arboviruses and arthropod-specific viruses by curating worldwide available data from Arbovirus Catalog, Section VIII-F of the Biosafety in Microbiological and Biomedical Laboratories 6th edition, Virus Metadata Resource of International Committee on Taxonomy of Viruses, and GenBank. This dataset includes a complete information on viral taxonomy, biological characteristics, vectors and vertebrate hosts, distribution, recommended biosafety levels, genome segment, and nucleotide/amino acid sequences, which will facilitate research by scientists/researchers of...

Detailed parameter

Detailed parameter

Detailed parameter

Detailed parameter

Supplement 1

We propose an infrared-sensitive negative differential transconductance (NDT) phototransistor based on a graphene/WS2/Au double junction with a SiO2/Ge gate. By changing the drain bias, diverse field-effect characteristics can be achieved. Typical p-type and n-type behavior is obtained under negative and positive drain bias, respectively. And NDT behavior is observed in the transfer curves under positive drain bias. It is believed to originate from competition between the top and bottom channel currents in stepped layers of...

Anaplastic lymphoma kinases (ALK) tyrosine kinase inhibitors (TKIs) are effective and safe targeted therapies used in advanced ALK-positive non-small cell lung cancers (NSCLC). However, ALK-TKIs associated cardiovascular toxicities in patients with ALK-positive NSCLCremain incompletely characterized. We conducted the first meta-analysis to investigate this. To determine the cardiovascular toxicities associated with these agents, we carried out a meta-analysis comparing ALK-TKIs with chemotherapy and a meta-analysis comparing crizotinib with other ALK-TKIs. Statistical analysis was conducted to calculate...

In present, there was no detailed report on the formulation optimization and quality evaluation of aprepitant (APT) injectable lipid emulsion (APT-IE). The aim of the present investigation was to prepare and evaluate its properties of APT-IE loaded with an APT phospholipid complex (APT-PC) in vitro and in vivo. APT-PC was obtained by solvent evaporation with APT and phospholipids, then analyzed by X-ray diffraction, Fourier transform infrared spectroscopy and differential scanning calorimetry. Lipid emulsions are a...