334 Works

Enhanced stromal H2S production via CBS upregulation promotes estrogen-stimulated human endometrial angiogenesis

Qian-Rong Qi, Thomas J. Lechuga, Basari Patel, Nicole A. Nguyen, Yi-Hua Yang, Yan Li, Sassi Sarnthiyakul, Quan-Wei Zhang, Jin Bai, Joshua Makhoul & Dong-Bao Chen
Angiogenesis is a physiological process for endometrial regeneration in the menstrual cycle and remodeling during pregnancy. Endogenous hydrogen sulfide (H2S), produced by cystathionine-β synthase (CBS) and cystathionine-γ lyase (CSE), is a potent proangiogenic factor; yet, whether the H2S system is expressed in the endometrium and whether H2S plays a role in endometrial angiogenesis are unknown. This study was to test whether estrogens stimulate endometrial H2S biosynthesis to promote endometrial microvascular endothelial cell (EMEC) angiogenesis. CBS...

CALFIN: Calving front dataset for East/West Greenland, 1972-2019

Daniel Cheng, Wayne Hayes & Eric Larour
We present Calving Front Machine (CALFIN), an automated method for extracting calving fronts from satellite images of marine-terminating glaciers. The results use Landsat imagery from 1972 to 2019 to generate 22,678 calving front lines across 66 Greenlandic glaciers. The method uses deep learning, and builds on existing work by Mohajerani et al., Zhang et al., and Baumhoer et al. Additional post-processing techniques allow for accurate segmentation of imagery into Shapefile outputs. This method is uniquely...

How Open Science Influences Next Developments in Grey Literature

Julia Gelfand & Anthony Lin
The practice of open science reinforces the intersections of open access, open data, open educational resources (textbooks), open methods, open standards, open transcription, open peer review, to promote how science is based on replication of experimental process and outcomes. Traditional publishing streams of books and journals capture just a fraction of the content now contextualized in open science. Our definition of open science blends the Foster Open Science Taxonomy with contextualizing science as Abraham Flexner...

Immature Representation or Immature Deployment? Modeling Child Pronoun Resolution

Hannah Forsythe & Lisa Pearl

Sexuality Leveraged Through Diversity: Recognizing LGBT+ Communities

Anthony Lin & Julia Gelfand

De ida y vuelta: Myriam Moscona entre el pasado búlgaro-sefardí y el presente mexicano

Jacobo Sefamí
pp. 155-165 This article studies the Sephardic sphere in the work of Myriam Moscona (Mexico City, 1955). It begins with an overview of this writer’s works, and then concentrates on two of her fundamental books on the subject: Tela de sevoya (2012) and Ansina (2015). The idea of displacement or wandering is explored not only as a family motive but also as the engine that nurtures the various explorations that Moscona has carried out throughout...

Academic libraries and collection development implications for grey literature

Julia Gelfand
The proliferation of grey literature (GL) in all subject areas poses great challenges, concerns and responsibilities for libraries. This paper examines the major issues most germane to the acquisition and collection development aspects of grey literature and providing access to it in library collections. With increasing academic and scholarly value placed in the grey literature and it being an original and primary source for information, many collection development policies are beginning to include grey literature...

Data from: Inferring pathobiology from structural MRI in schizophrenia and bipolar disorder: modeling head motion and neuroanatomical specificity

Nailin Yao, Anderson M. Winkler, Jennifer Barrett, Gregory A. Book, Tamara Beetham, Rachel Horseman, Olivia Leach, Karen Hodgson, Emma E. Knowles, Samuel Mathias, Michael C. Stevens, Michal Assaf, Theo G. M. Van Erp, Godfrey D. Pearlson & David C. Glahn
Despite over 400 peer-reviewed structural MRI publications documenting neuroanatomic abnormalities in bipolar disorder and schizophrenia, the confounding effects of head motion and the regional specificity of these defects are unclear. Using a large cohort of individuals scanned on the same research dedicated MRI with broadly similar protocols, we observe reduced cortical thickness indices in both illnesses, though less pronounced in bipolar disorder. While schizophrenia (n = 226) was associated with wide-spread surface area reductions, bipolar...

Data from: Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation

Angele M. De Silva, Rían W. Manville & Geoffrey W. Abbott
A third of the global population relies heavily upon traditional or folk medicines, such as the African shrub Mallotus oppositifolius. Here, we used pharmacological screening and electrophysiological analysis in combination with in silico docking and site-directed mutagenesis to elucidate the effects of M. oppositifolius constituents on KCNQ1, a ubiquitous and influential cardiac and epithelial voltage-gated potassium (Kv) channel. Two components of the M. oppositifolius leaf extract, mallotoxin (MTX) and 3-ethyl-2-hydroxy-2-cyclopenten-1-one (CPT1), augmented KCNQ1 current by...

The impact of Rhodiola Rosea on biomarkers of diabetes, inflammation, and microbiota in a leptin receptor-knockout mouse model

Robert Courville, Mahtab Jafari, Richard Van Etten, John Chaston, Jasmin Grace Juanson Arabit, Dara Kiani, Cindy Duy Nguyen, Nilamani Jena, Zhong-Ying Liu & Prasanthi Tata
Type 2 diabetes is the most prevalent endocrine disease in the world, and recently the gut microbiota have become a potential target for its management. Recent studies have illustrated that this disease may predispose individuals to certain microbiome compositions, and treatments like metformin have been shown to change gut microbiota and their associated metabolic pathways. However, given the limitations and side effects associated with pharmaceuticals currently being used for therapy of diabetes, there is a...

Evaluating Promising Practices in Undergraduate STEM Lecture Courses

Mark Warschauer, Lynn Reimer, Kameryn Denaro, Gabe Orona, Katerina Schenke, Tutrang Nguyen, Amanda Niili, Di Xu, Sabrina Solanki & Tate Tamara
Observations were collected to examine instructional practices in large undergraduate lecture courses at UCI, particularly in STEM (science, technology, engineering, and mathematics). The study began in 2012 with the intention of documenting the relative presence or absence of practices that potentially promote more active and engaged learning (e.g., enhanced faculty-student interaction, enhanced peer interaction, greater attention to problem-solving strategies, more opportunities for personalized learning, opportunities to receive and communicate information across diverse channels and modalities,...

Seismic detection of oceanic internal gravity waves from subaerial seismometers

Kristen Davis, Heather Shaddox, Emily Brodsky & Thorne Lay
Oceanic internal gravity waves propagate along density stratification within the water column and are ubiquitous. They can propagate thousands of kilometers before breaking in shoaling bathymetry and the ensuing turbulent mixing affects coastal processes and climate feedbacks. Despite their importance, internal waves are intrinsically difficult to detect as they result in only minor amplitudedeflection of the sea surface; the need for global detection and long time series of internal waves motivates a search for geophysical...

Differentially expressed genes of Peromyscus leucopus fibroblast cultures treated with lipopolysaccharide or buffer alone

Alan Barbour, Youwen Zhang, Ana Milovic & Hippokratis Kiaris
This experiment and its results were part of a larger study of the differential responses of the white-footed deermouse Peromyscus leucopus and the house mouse Mus musculus to single injections of lipopolysaccharide (LPS). The entire study is presented in the associated manuscript in submission and in the listed pre-print. The aim of this particular experiment was to identify differentially expressed genes (DEG) of fibroblast cultures of P. leucopus. The experiment identified 543 DEGs that were...

Physical processes controlling the rifting of Larsen C Ice Shelf, Antarctica, prior to the calving of iceberg A68 in 2017

Eric Rignot, Eric Larour, Bernd Scheuchl & Mattia Poinelli
The sudden propagation of a major pre-existing rift (full-thickness crack) in late 2016 on the Larsen C Ice Shelf, Antarctica lead to the calving of tabular iceberg A68 in July 2017, one of the largest icebergs on record, posing a threat for the stability of the remainder of the ice shelf. As for other ice shelves, the physical processes that led to the activation of the A68 rift and controlled its propagation have not been...

Dataset for: Fast retreat of Pope, Smith, and Kohler glaciers in West Antarctica observed by satellite interferometry

Pietro Milillo, Eric Rignot, Paola Rizzoli, Bernd Scheuchl, Jeremie Mouginot, Jose Luis Bueso Bello, Pau Prats Iraola & Luigi Dini
Pope, Smith, and Kohler glaciers, in the Amundsen Sea Embayment of West Antarctica, have experienced enhanced ocean-induced ice-shelf melt, glacier acceleration, ice thinning, and grounding line retreat in the past thirty years, in a glaciological setting with retrograde bedrock slopes conducive to marine ice sheet instability. Here we present observations of the grounding line retreat of these glaciers since 2014 using a constellation of interferometric radar satellites with a short revisit cycle combined with precision...

Data from: Widespread grounding line retreat of Totten Glacier, East Antarctica, over the 21st century

Tyler Pelle, Mathieu Morlighem, Helene Seroussi & Yoshihiro Nakayama
Totten Glacier, the primary ice discharger of East Antarctica, contains 3.85 m sea level rise equivalent ice mass (SLRe) and has displayed ocean-driven dynamic change since at least the early 2000s. We project Totten’s evolution through 2100 in a fully coupled ice-ocean model, forced at the ocean boundaries with anomalies in CMIP6 projected temperature, salinity, and velocity. Consistent with previous studies, the Antarctic Slope Current continues to modulate warm water inflow towards Totten in future...

Dataset S1: Results of modeled spectral competition between Synechococcus type IV chromatic acclimaters (CA4) and blue and green light-harvesting specialists

Raisha Lovindeer
This dataset is the output of a one-dimensional model that simulated the time evolution of growth of Synechococcus phycoerythrin pigment types, with low, high, and variable ratios of phycourobilin to phycoerythrobilin (PUB:PEB; pigment types 3a, 3c and 3d, respectively). The model used to generate the output was built on existing published equations of competition for light color within an ocean water column by Stomp and coworkers. Our version of the model was coded in MATLAB,...

Leaf gas exchange in Ipomopsis aggregata under manipulated snowmelt timing and summer precipitation

Jocelyn Navarro, John Powers, Ayaka Paul & Diane Campbell
Vegetative traits of plants can respond directly to changes in the environment, such as those occurring under climate change. That phenotypic plasticity could be adaptive, maladaptive, or neutral. We manipulated the timing of spring snowmelt and amount of summer precipitation in factorial combination and examined the responses of photosynthetic rate, stomatal conductance, and intrinsic water-use efficiency (iWUE) in the subalpine herb Ipomopsis aggregata. The experiment was repeated in three years differing in natural timing of...

Random peptide sequences binding amyloid monoclonal antibodies

Charles Glabe
Antibodies against Aß amyloid are indispensable research tools and potential therapeutics for Alzheimer’s Disease, but display several unusual properties, such as specificity for aggregated forms of the peptide, ability to distinguish polymorphic aggregate structures and ability to recognize generic aggregation-related epitopes formed by unrelated amyloid sequences. Understanding the mechanisms underlying these unusual properties of anti-amyloid antibodies and the structures of their corresponding epitopes is crucial for the understanding why antibodies display different therapeutic activities and...

Tuned inhibition in perceptual decision-making circuits can explain seemingly suboptimal confidence behavior: S4 data, evidence for tuned inhibition in macaque superior colliculus

Megan Peters, Brian Maniscalco, Brian Odegaard, Piercesare Grimaldi, Seong Hah Cho, Michele Basso & Hakwan Lau
This dataset contains online spike-sorted single-unit recordings from one Rhesus macaque who performed a dot-motion discrimination task while neural data was recorded with a 16-channel v-probe from superior colliculus neurons. Full methods for data collection, including description of the stimuli and task, surgical details, ethics statement, funding information, and other relevant details, are available in the above-referenced manuscript, section S4 Text.

Experimental test of the combined effects of water availability and flowering time on pollinator visitation and seed set

M. Kate Gallagher & Diane Campbell
Climate change is likely to alter both flowering phenology and water availability for plants. Either of these changes alone can affect pollinator visitation and plant reproductive success. The relative impacts of phenology and water, and whether they interact in their impacts on plant reproductive success remain, however, largely unexplored. We manipulated flowering phenology and soil moisture in a factorial experiment with the subalpine perennial Mertensia ciliata (Boraginaceae). We examined responses of floral traits, floral abundance,...

The tale of two ice shelves: Zachariae Isstrøm and Nioghalvfjerdsfjorden, Northeast Greenland

Lu An, Eric Rignot, Michael Wood, Josh Willis, Jeremie Mouginot & Shfaqat Khan
Oceanography and gravity data of Northeastern Greenland reveal ocean temperature and bathymetry in front of Zachariae Isstrøm (ZI) and Nioghalvfjerdsfjorden (79N), which hold a 1.1-m sea-level rise ice volume equivalent but underwent different evolutions. Sub-surface, warm, salty water of Atlantic origin has easier access to ZI than to 79N because of bathymetric barriers. We reconstruct ice removal by the ocean at the grounding line and floatation retreat from thinning to explain the observed grounding line...

Differentially expressed genes in the blood, spleen, and liver of Peromyscus leucopus and Mus musculus with or without treatment with lipopolysaccharide

Alan Barbour, Ana Milovic, Gabriela Balderrama-Gutierrez & Ali Mortazavi
Animals that are competent reservoirs of zoonotic pathogens commonly suffer little morbidity from the infections. To investigate mechanisms of this tolerance of infection, we used single-dose lipopolysaccharide (LPS) as an experimental model of inflammation and compared the responses by two rodents: Peromyscus leucopus, white-footed deermouse and reservoir for agents of Lyme disease and other zoonoses, and the house mouse Mus musculus. Four hours after injection with LPS or saline, blood, spleen and liver samples were...

Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow

Diana Le Duc, Akhil Velluva, Molly Cassatt-Johnstone, Remi-Andre Olsen, Sina Baleka, Chen-Ching Lin, Johannes R. Lemke, John R. Southon, Alexander Burdin, Ming-Shan Wang, Sonja Grunewald, Wilfried Rosendahl, Ulrich Joger, Sereina Rutschmann, Thomas B. Hildebrandt, Guido Fritsch, James A. Estes, Janet Kelso, Love Dalén, Michael Hofreiter, Beth Shapiro & Torsten Schöneberg
Steller’s sea cow, an extinct sirenian and one of the largest Quaternary mammals, was described by Georg Steller in 1741 and eradicated by humans within 27 years. Here, we complement Steller’s descriptions with paleogenomic data from 12 individuals. We identified convergent evolution between Steller’s sea cow and cetaceans but not extant sirenians, suggesting a role of several genes in adaptation to cold environments. Among these are inactivations of lipoxygenase genes, which in humans and mouse...

Monitoring marine bound debris using UAS on the US-Mexico Border

Jochen Schubert, Napoleon Gudino, Steven Wright & Waylon Matson
The Tijuana river estuary suffers from overwhelming solid-waste contamination such as marine bound plastics, tires, and sediment. Funded by the US EPA's Border 2020 program (SOLTA-C-19-008), this project intends to establish a framework for bi-national monitoring of trans-boundary, marine bound trash (TBMBT) using light-weight unmanned aerial systems (UASs), also known as drones. The developed framework is intended to benefit 1) border authorities through the establishment of a low-cost, minimally invasive, operational standard to monitor TBMBT...

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