Classification of Type 2 Diabetes Genetic Variants and a Novel Genetic Risk Score Association with Insulin ClearanceMark Goodarzi, Nicholette D Palmer, Jinrui Cui, Xiuqing Guo, Yii-Der I Chen, Kent D Taylor, Leslie J Raffel, Lynne E Wagenknecht, Thomas A Buchanan, Willa A Hsueh & Jerome I Rotter
Abstract Context Genome-wide association studies have identified >450 single nucleotide polymorphisms (SNPs) for type 2 diabetes (T2D). Objective To facilitate use of these SNPs in future genetic risk score (GRS)-based analyses, we aimed to classify the SNPs based on physiology. We also sought to validate GRS associations with insulin-related traits in deeply-phenotyped Mexican Americans. Design, Setting, and Participants 457 T2D SNPs from the literature were assigned physiologic function based on association studies and cluster analyses....
Existing needs to manage flood risk in the U.S. are underserved by available flood hazard information. This contributes to an alarming escalation of flood impacts that amount to hundreds of billions of dollars per year and countless disrupted lives and affected communities. Making information about flood hazards useful for the range of decisions by actors that dictate the consequences of flooding poses many challenges. This dataset contains a collection of flood hazard mapping layers for...
Crystal Cove Conservancy operates the Crystal Cove Marine Protected Area Science Cruise in partnership with Newport Landing Sportfishing. Under the supervision of trained Crystal Cove Conservancy staff, junior high school and high school students collect data on fish and plankton biodiversity and nearshore water quality in the Crystal Cove Marine Conservation Area, following protocols designed in partnership with UCI and other researchers. See README file for more detailed information. “Data made available in the OC...
Data from: Diet variability among insular populations of Podarcis lizards reveals diverse strategies to face resource-limited environmentsMaxime Taverne, Anne-Claire Fabre, Nina King-Gillies, Marija Krajnović, Duje Lisičić, Louise Martin, Leslie Michal, Donat Petricioli, Anamaria Stambuk, Zoran Tadić, Chloé Vigliotti, Beck Wehrle & Anthony Herrel
Access to resources is a dynamic and multi-causal process that determines the success and survival of a population. It is therefore often challenging to disentangle the factors affecting ecological traits like diet. Insular habitats provide a good opportunity to study how variation in diet originates, in particular in populations of mesopredators such as lizards. Indeed, high levels of population density associated with low food abundance and low predation are selection pressures typically observed on islands....
Data from: Insensitivity of the cloud response to surface warming under radical changes to boundary layer turbulence and cloud microphysics: results from the ultraparameterized CAMHossein Parishani
This data set contains the simulation outputs used in the study summarized below: We study the cloud response to a +4K surface warming in a new multiscale climate model that uses enough interior resolution to begin explicitly resolving boundary layer turbulence (i.e., ultraparameterization or UP). UP's predictions are compared against those from standard superparameterization (SP). The mean cloud radiative effect feedback turns out to be remarkably neutral across all of our simulations, despite some radical...
Supporting Data for Relative Humidity Effect on the Formation of Highly Oxidized Molecules and New Particles during Monoterpene OxidationJames Smith & Jingjun Jiang
It has been widely observed around the world that the frequency and intensity of new particle formation (NPF) events are reduced during periods of high relative humidity (RH). The current study focuses on how RH affects the formation of highly oxidized molecules (HOMs), which are key components of NPF and initial growth caused by oxidized organics. The ozonolysis of α-pinene, limonene, and △3-carene, with and without OH-scavenger, were carried out under low NOx conditions under...
A predator's ability to capture prey depends critically on how it coordinates its approach in response to a prey's motion. Flying insects, bats, and raptors are capable of capturing prey with a strategy known as parallel navigation, which allows a predator to move directly toward the anticipated point of interception. It is unclear if predators using other modes of locomotion are capable of employing this strategy when pursuing evasive prey. Using kinematic measurements and mathematical...
Data from: The geographical variation of network structure is scale dependent: understanding the biotic specialization of host-parasitoid networksNuria Galiana, Bradford A. Hawkins & Jose M. Montoya
Research on the structure of ecological networks suggests that a number of universal patterns exist. Historically, biotic specialization has been thought to increase towards the Equator. Yet, recent studies have challenged this view showing non-conclusive results. Most studies analysing the geographical variation in biotic specialization focus, however, only on the local scale. Little is known about how the geographical variation of network structure depends on the spatial scale of observation (i.e., from local to regional...
These data are associated with the manuscript "Mortality risk across life stages and habitats of an intertidal mussel (Mytilus californianus)". Code for statsitical analyses can be found on L. Pandori's GitHub (https://github.com/llmpandori/Mussel_Habitat_Risk). Feel free to conatct L. Pandori with any requests regarding this dataset.
The living tree sloths Choloepus and Bradypus are the only remaining members of Folivora, a major xenarthran radiation that occupied a wide range of habitats in many parts of the western hemisphere during the Cenozoic, including both continents and the West Indies. Ancient DNA evidence has played only a minor role in folivoran systematics, as most sloths lived in places not conducive to genomic preservation. Here we utilize collagen sequence information, both separately and in...
Data from: Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravisJames F. Howard, Vera Bril, Ted M. Burns, Renato Mantegazza, Malgorzata Bilinska, Andrzej Szczudlik, Said Beydoun, Francisco Javier Rodriguez De Rivera Garrido, Fredrik Piehl, Mariarosa Rottoli, Philip Van Damme, Tuan Vu, Amelia Evoli, Miriam Freimer, Tahseen Mozaffar, E. Sally Ward, Torsten Dreier, Peter Ulrichts, Katrien Verschueren, Antonio Guglietta, Hans De Haard, Nicolas Leupin & Jan J. G. M. Verschuuren
Objective: To investigate safety and explore efficacy of efgartigimod (ARGX-113), an anti-neonatal Fc receptor immunoglobulin G1 Fc fragment, in patients with generalized myasthenia gravis (gMG) with a history of anti-acetylcholine receptor (AChR) autoantibodies, who were on stable standard-of-care myasthenia gravis (MG) treatment. Methods: A phase 2, exploratory, randomized, double-blind, placebo-controlled, 15-center study is described. Eligible patients were randomly assigned (1:1) to receive 4 doses over a 3-week period of either 10 mg/kg IV efgartigimod or...
Supporting data for Formation of Highly Oxidized Molecules from NO3 Radical Oxidation of Δ-3-Carene: A Computational MechanismDanielle Draper, Nanna Myllys, Noora Hyttinen, Kristian Moller, Henrik Kjaergaard, Juliane Fry, James Smith & Theo Kurten
NO3 radical oxidation of most monoterpenes is a significant source of secondary organic aerosol (SOA) in many regions influenced by both biogenic and anthropogenic emissions, but there are very few published mechanistic studies of NO3 chemistry beyond simple 1st generation products. Here, we present a computationally-derived mechanism detailing the unimolecular pathways available to the 2nd generation of peroxy radicals following NO3 oxidation of Δ-3-carene, defining generations based on the sequence of peroxy radicals formed rather...
Data from: Chiral Majorana fermion modes in a quantum anomalous Hall insulator–superconductor structureQing Lin He, Lei Pan, Alexander L. Stern, Edward C. Burks, Xiaoyu Che, , Jing Wang, Biao Lian, Quan Zhou, Eun Sang Choi, Koichi Murata, Xufeng Kou, Zhijie Chen, Tianxiao Nie, Qiming Shao, Yabin Fan, Shou-Cheng Zhang, Kai Liu, Jing Xia & Kang L. Wang
Majorana fermion is a hypothetical particle that is its own antiparticle. We report transport measurements that suggest the existence of one-dimensional chiral Majorana fermion modes in the hybrid system of a quantum anomalous Hall insulator thin film coupled with a superconductor. As the external magnetic field is swept, half-integer quantized conductance plateaus are observed at the locations of magnetization reversals, giving a distinct signature of the Majorana fermion modes. This transport signature is reproducible over...
Complete map of ice motion in Antarctica combining phase data in the interior and speckle tracking in the fast-moving sectors. We present a new map of Antarctic ice velocity that is ten times more precise than prior maps and reveals ice motion at a high precision over 80% of the continent versus 20% in the past. The ice motion vector map provides novel constrains on interior ice motion and its connection with the glaciers and...
Multistate hybrid time-dependent density functional theory with surface hopping accurately captures ultrafast thymine photodeactivationShane Parker, Saswata Roy & Filipp Furche
Collected trajectories for paper "Multistate hybrid time-dependent density functional theory with surface hopping accurately captures ultrafast thymine photodeactivation".
Data from: Context-dependent scaling of kinematics and energetics during contests and feeding in mantis shrimpP.A. Green, M.J. McHenry & S.N. Patek
Measurements of energy use, and its scaling with size, are critical to understanding how organisms accomplish myriad tasks. For example, energy budgets are central to game theory models of assessment during contests and underlie patterns of feeding behavior. Clear tests connecting energy to behavioral theory require measurements of the energy use of single individuals for particular behaviors. Many species of mantis shrimp (Stomatopoda: Crustacea) use elastic energy storage to power high-speed strikes that they deliver...
University of California, Irvine42
Jet Propulsion Lab4
French National Centre for Scientific Research3
Grenoble Alpes University3
Institute of Hydrobiology2
Central South University2
Northwest Normal University2
Air Force Medical University2
Fudan University Shanghai Cancer Center2