8 Works

Data from: Simulated annealing approach to vascular structure with application to the coronary arteries

Jonathan Keelan, James P. Hague & Emma M. L. Chung
Do the complex processes of angiogenesis during organism development ultimately lead to a near optimal coronary vasculature in the organs of adult mammals? We examine this hypothesis using a powerful and universal method, built on physical and physiological principles, for the determination of globally energetically optimal arterial trees. The method is based on simulated annealing, and can be used to examine arteries in hollow organs with arbitrary tissue geometries. We demonstrate that the approach can...

Data from: Anaesthetic interventions for prevention of awareness during surgery

Anthony G. Messina, Michael Wang, Marshall J. Ward, Chase C. Wilker, Brett B. Smith, Daniel P. Vezina, Nathan Pace & Nathan Leon Pace
BACKGROUND: General anaesthesia is usually associated with unconsciousness. 'Awareness' is when patients have postoperative recall of events or experiences during surgery. 'Wakefulness' is when patients become conscious during surgery, but have no postoperative recollection of the period of consciousness. OBJECTIVES: To evaluate the efficacy of two types of anaesthetic interventions in reducing clinically significant awareness: - anaesthetic drug regimens; and - intraoperative anaesthetic depth monitors. SEARCH METHODS: We searched the Cochrane Central Register of Controlled...

Data from: Population characteristics, mechanisms of primary care and premature mortality in England: a cross-sectional study

Richard Baker, Kate Honeyford, Louis S. Levene, , David R. Jones, M. John Bankart & Tim Stokes
Objectives. Health systems with strong primary care tend to have better population outcomes, but in many countries demand for care is growing. We sought to identify mechanisms of primary care that influence premature mortality. Design. We developed a conceptual model of the mechanisms by which primary care influences premature mortality, and undertook a cross-sectional study in which population and primary care variables reflecting the model were used to explain variations in mortality under aged 75...

Data from: Environmental change mediates mate choice for an extended phenotype, but not for mate quality

Megan L. Head, Rebecca J. Fox & Iain Barber
Sexual cues, including extended phenotypes, are expected to be reliable indicators of male genetic quality and/or provide information on parental quality. However, the reliability of these cues may be dependent on stability of the environment, with heterogeneity affecting how selection acts on such traits. Here we test how environmental change mediates mate choice for multiple sexual traits, including an extended phenotype – the structure of male-built nests – in stickleback fish. First, we manipulated the...

Data from: Revisiting Brownian motion as a description of animal movement: a comparison to experimental movement data

Daniel Bearup, Carly M. Benefer, Sergei V. Petrovskii & Rod P. Blackshaw
Characterization of patterns of animal movement is a major challenge in ecology with applications to conservation, biological invasions and pest monitoring. Brownian random walks, and diffusive flux as their mean field counterpart, provide one framework in which to consider this problem. However, it remains subject to debate and controversy. This study presents a test of the diffusion framework using movement data obtained from controlled experiments. Walking beetles (Tenebrio molitor) were released in an open circular...

Data from: Introgression of chromosome segments from multiple alien species in wheat breeding lines with wheat streak mosaic virus resistance

Niaz Ali, J. S. Heslop-Harrison, Habib Ahmad, Robert A. Graybosch, Gary L. Hein & Trude Schwarzacher
Pyramiding of alien-derived Wheat streak mosaic virus (WSMV) resistance and resistance enhancing genes in wheat is a cost-effective and environmentally safe strategy for disease control. PCR-based markers and cytogenetic analysis with genomic in situ hybridisation were applied to identify alien chromatin in four genetically diverse populations of wheat (Triticum aestivum) lines incorporating chromosome segments from Thinopyrum intermedium and Secale cereale (rye). Out of 20 experimental lines, 10 carried Th. intermedium chromatin as T4DL*4Ai#2S translocations, while,...

Data from: High throughput method for analysis of repeat number for 28 phase variable loci of Campylobacter jejuni strain NCTC11168

Lea Lango-Scholey, Jack Aidley, Alexandra Woodacre, Michael A. Jones & Christopher D. Bayliss
Mutations in simple sequence repeat tracts are a major mechanism of phase variation in several bacterial species including Campylobacter jejuni. Changes in repeat number of tracts located within the reading frame can produce a high frequency of reversible switches in gene expression between ON and OFF states. The genome of C. jejuni strain NCTC11168 contains 29 loci with polyG/polyC tracts of seven or more repeats. This protocol outlines a method—the 28-locus-CJ11168 PV-analysis assay—for rapidly determining...

Data from: Pigmented anatomy in Carboniferous cyclostomes and the evolution of the vertebrate eye

Sarah E. Gabbott, Philip C.J. Donoghue, Robert S. Sansom, Jakob Vinther, Andrei Dolocan, Mark A. Purnell & Philip C. J. Donoghue
The success of vertebrates is linked to the evolution of a camera-style eye and sophisticated visual system. In the absence of useful data from fossils, scenarios for evolutionary assembly of the vertebrate eye have been based necessarily on evidence from development, molecular genetics and comparative anatomy in living vertebrates. Unfortunately, steps in the transition from a light-sensitive ‘eye spot’ in invertebrate chordates to an image-forming camera-style eye in jawed vertebrates are constrained only by hagfish...

Registration Year

  • 2016

Resource Types

  • Dataset


  • University of Leicester
  • Keele University
  • Plymouth University
  • ARUP Laboratories (United States)
  • Dartmouth–Hitchcock Medical Center
  • The University of Texas at Austin
  • Hazara University
  • Australian National University
  • University of Nottingham
  • University of Otago