4 Works

Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100

Simona Capponi, Nadja Stöffler, Manuel Irimia, Frederik M.A. Van Schaik, Mercedes M. Ondik, Martin L. Biniossek, Lisa Lehmann, Julia Mitschke, Marit W. Vermunt, Menno P. Creyghton, Ann M. Graybiel, Thomas Reinheckel, Oliver Schilling, Benjamin J. Blencowe, Jill R. Crittenden & H. Th. Marc Timmers
Neuronal microexons represent the most highly conserved class of alternative splicing events and their timed expression shapes neuronal biology, including neuronal commitment and differentiation. The six-nt microexon 34ʹ is included in the neuronal form of TAF1 mRNA, which encodes the largest subunit of the basal transcription factor TFIID. In this study, we investigate the tissue distribution of TAF1-34ʹ mRNA and protein and the mechanism responsible for its neuronal-specific splicing. Using isoform-specific RNA probes and antibodies,...

A historical-genetic reconstruction of human extra-pair paternity

Maarten H.D. Larmuseau, Pieter Van Den Berg, Sofie Claerhout, Francesc Calafell, Alessio Boattini, Leen Gruyters, Michiel Vandenbosch, Kelly Nivelle, Ronny Decorte & Tom Wenseleers
Paternity testing using genetic markers has shown that extra-pair paternity (EPP) is common in many pair-bonded species. Evolutionary theory and empirical data show that extra-pair copulations can increase the fitness of males as well as females. This can carry a significant fitness cost for the social father, who then invests in rearing offspring that biologically are not his own. In human populations, the incidence and correlates of extra-pair paternity remain highly contentious. Here, we use...

Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100

Simona Capponi, Nadja Stöffler, Manuel Irimia, Frederik M.A. Van Schaik, Mercedes M. Ondik, Martin L. Biniossek, Lisa Lehmann, Julia Mitschke, Marit W. Vermunt, Menno P. Creyghton, Ann M. Graybiel, Thomas Reinheckel, Oliver Schilling, Benjamin J. Blencowe, Jill R. Crittenden & H. Th. Marc Timmers
Neuronal microexons represent the most highly conserved class of alternative splicing events and their timed expression shapes neuronal biology, including neuronal commitment and differentiation. The six-nt microexon 34ʹ is included in the neuronal form of TAF1 mRNA, which encodes the largest subunit of the basal transcription factor TFIID. In this study, we investigate the tissue distribution of TAF1-34ʹ mRNA and protein and the mechanism responsible for its neuronal-specific splicing. Using isoform-specific RNA probes and antibodies,...

The impact of genetic adaptation on chimpanzee subspecies differentiation

Joshua Schmidt, Sergi Castellano, Marc De Manuel, Aida Andrés & Tomas Marques-Bonet
Chimpanzees, humans’ closest relatives, are in danger of extinction. Aside from direct human impacts such as hunting and habitat destruction, a key threat is transmissible disease. As humans continue to encroach upon their habitats, which shrink in size and grow in density, the risk of inter-population and cross-species viral transmission increases, a point dramatically made in the reverse with the global HIV/AIDS pandemic. Inhabiting central Africa, the four subspecies of chimpanzees differ in demographic history...

Registration Year

  • 2019
    4

Resource Types

  • Dataset
    2
  • Text
    2

Affiliations

  • Pompeu Fabra University
    4
  • University of Freiburg
    2
  • Institució Catalana de Recerca i Estudis Avançats
    2
  • Heidelberg University
    2
  • Barcelona Institute for Science and Technology
    2
  • University Medical Center Freiburg
    2
  • Centre for Genomic Regulation
    2
  • German Cancer Research Center
    2
  • Ludwig-Maximilians-Universität München
    2
  • University of Bologna
    1