Supplemental material, sj-docx-1-msj-10.1177_13524585231161253 for Humoral immune responses remain quantitatively impaired but improve qualitatively in anti-CD20-treated patients with multiple sclerosis after three or four COVID-19 vaccinations by Carolin Otto, Tatjana Schwarz, Lara M Jeworowski, Marie L Schmidt, Felix Walper, Florence Pache, Patrick Schindler, Moritz Niederschweiberer, Andi Krumbholz, Ruben Rose, Christian Drosten, Klemens Ruprecht and Victor M Corman in Multiple Sclerosis Journal

Additional file 4: Table S2: Spearman correlation analysis with and without rituximab intervention in the NMOSD group. n.s.: not significant; *: p < 0.01.

Additional file 2: Table S2. Summary of fields of view and dimensions used to define retinal regions in included studies.

Additional file 3: Table S3. Exclusion criteria and additional information of included studies.

Additional file 2: Table S1. Individual animals, parasite burden, samples per region, and Ascaris intestines included in the microbiome analysis. Table S2. Core ASVs by sample type. Table S3. Permutational analysis of variance for bacterial taxa composition in different gastrointestinal compartments from Ascaris infected pigs. Table S4. Permutational analysis of variance for bacterial taxa composition in jejunum and Ascaris from infected pigs. Table S5. Permutational analysis of variance for bacterial taxa composition in different gastrointestinal...

Additional file 1: Table S1. OCT-A metrics and regions assessed in the included studies with term definitions.

Supplementary Material 3

Additional file 2. Normalized transcript counts.

Abstract We previously discovered a sex-by-genotype defect in microglia function using a heterozygous germline knockout mouse model of Neurofibromatosis type 1 (Nf1 ± mice), in which only microglia from male Nf1 ± mice exhibited defects in purinergic signaling. Herein, we leveraged an unbiased proteomic approach to demonstrate that male, but not female, heterozygous Nf1 ± microglia exhibit differences in protein expression, which largely reflect pathways involved in cytoskeletal organization. In keeping with these predicted defects...

Supplemental material, sj-docx-1-msj-10.1177_13524585231151212 for Cognition in patients with neuromyelitis optica spectrum disorders: A prospective multicentre study of 217 patients (CogniNMO-Study) by Martin W Hümmert, Carlotta Stern, Friedemann Paul, Ankelien Duchow, Judith Bellmann-Strobl, Ilya Ayzenberg, Carolin Schwake, Ingo Kleiter, Kerstin Hellwig, Sven Jarius, Brigitte Wildemann, Makbule Senel, Achim Berthele, Katrin Giglhuber, Felix Luessi, Matthias Grothe, Luisa Klotz, Rasmus Schülke, Stefan Gingele, Jürgen H Faiss, Annette Walter, Clemens Warnke, Florian Then Bergh, Orhan Aktas, Marius Ringelstein, Jan-Patrick...

Supplemental material, sj-docx-1-msj-10.1177_13524585231161253 for Humoral immune responses remain quantitatively impaired but improve qualitatively in anti-CD20-treated patients with multiple sclerosis after three or four COVID-19 vaccinations by Carolin Otto, Tatjana Schwarz, Lara M Jeworowski, Marie L Schmidt, Felix Walper, Florence Pache, Patrick Schindler, Moritz Niederschweiberer, Andi Krumbholz, Ruben Rose, Christian Drosten, Klemens Ruprecht and Victor M Corman in Multiple Sclerosis Journal

Abstract Background Intestinal helminths are extremely prevalent among humans and animals. In particular, intestinal roundworms affect more than 1 billion people around the globe and are a major issue in animal husbandry. These pathogens live in intimate contact with the host gut microbiota and harbor bacteria within their own intestines. Knowledge of the bacterial host microbiome at the site of infection is limited, and data on the parasite microbiome is, to the best of our...

Abstract Background Intestinal helminths are extremely prevalent among humans and animals. In particular, intestinal roundworms affect more than 1 billion people around the globe and are a major issue in animal husbandry. These pathogens live in intimate contact with the host gut microbiota and harbor bacteria within their own intestines. Knowledge of the bacterial host microbiome at the site of infection is limited, and data on the parasite microbiome is, to the best of our...

Additional file 2: Figure S2. Analysis of TCR Vα24-Jα18-positive NKT cells. The downstream analysis of NKT cells with TCR Vα24-Jα18-positive gating among the NMOSD group showed significantly higher CD83 expression against the Normal Control group (D).

Abstract Background and objectives Inhibition of terminal complement in neuromyelitis optica spectrum disorder (NMOSD) using eculizumab helps prevent relapses, but the exact mechanism of action of the drug remains unclear. Similarly, genetic variants in the Fc Gamma receptor 3A (FCGR3A), also known as CD16, are correlated with outcomes in NMOSD, but the immune cells expressing those CD16 are unknown. We compared CD16 expression on immune cells modulated by complement activity in natural killer (NK) cells...

Abstract Background During their lifetime, animals must adapt their behavior to survive in changing environments. This ability requires the nervous system to undergo adjustments at distinct temporal scales, from short-term dynamic changes in expression of neurotransmitters and receptors to longer-term growth, spatial and connectivity reorganization, while integrating external stimuli. The nematode Caenorhabditis elegans provides a model of nervous system plasticity, in particular its dauer exit decision. Under unfavorable conditions, larvae will enter the non-feeding and...

Additional file 3: Table S3. Exclusion criteria and additional information of included studies.

Supplementary Material 3

Background:There is limited and inconsistent information on the prevalence of cognitive impairment in neuromyelitis optica spectrum disorders (NMOSD).Objective:To assess cognitive performance and changes over time in NMOSD.Methods:This study included data from 217 aquaporin-4-IgG-seropositive (80%) and double-seronegative NMOSD patients. Cognitive functions measured by Symbol Digit Modalities Test (SDMT), Paced Auditory Serial-Addition Task (PASAT), and/or Multiple Sclerosis Inventory Cognition (MuSIC) were standardized against normative data (N = 157). Intraindividual cognitive performance at 1- and 2-year follow-up was...

Background:There is limited and inconsistent information on the prevalence of cognitive impairment in neuromyelitis optica spectrum disorders (NMOSD).Objective:To assess cognitive performance and changes over time in NMOSD.Methods:This study included data from 217 aquaporin-4-IgG-seropositive (80%) and double-seronegative NMOSD patients. Cognitive functions measured by Symbol Digit Modalities Test (SDMT), Paced Auditory Serial-Addition Task (PASAT), and/or Multiple Sclerosis Inventory Cognition (MuSIC) were standardized against normative data (N = 157). Intraindividual cognitive performance at 1- and 2-year follow-up was...

Additional file 2: Figure S2. Analysis of TCR Vα24-Jα18-positive NKT cells. The downstream analysis of NKT cells with TCR Vα24-Jα18-positive gating among the NMOSD group showed significantly higher CD83 expression against the Normal Control group (D).

Additional file 3: Table S1: Spearman correlation analysis for the NMOSD group between the parameters. n.s.: not significant; *: p < 0.05; **: p < 0.01; ***: p < 0.001; ****: p < 0.0001.

Additional file 1: Supplementary Figures.

Supplementary Material 1

Supplementary Material 2