220 Works

Additional file 1 of A cross-sectional survey on the early impact of COVID-19 on the uptake of decentralised trial methods in the conduct of clinical trials

Arnela Suman, Jasmijn van Es, Helga Gardarsdottir, Diederick E. Grobbee, Kimberly Hawkins, Megan A. Heath, Isla S. Mackenzie, Ghislaine van Thiel & Mira G. P. Zuidgeest
Additional file 1.

Additional file 2 of The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry

Hiba Mohammed Taha, Reza Aalizadeh, Nikiforos Alygizakis, Jean-Philippe Antignac, Hans Peter H. Arp, Richard Bade, Nancy Baker, Lidia Belova, Lubertus Bijlsma, Evan E. Bolton, Werner Brack, Alberto Celma, Wen-Ling Chen, Tiejun Cheng, Parviel Chirsir, Ľuboš Čirka, Lisa A. D’Agostino, Yannick Djoumbou Feunang, Valeria Dulio, Stellan Fischer, Pablo Gago-Ferrero, Aikaterini Galani, Birgit Geueke, Natalia Głowacka, Juliane Glüge … & Emma L. Schymanski
Additional file 2: Overview of the NORMAN-SLE website (DOCX format) as of 30 May 2022 [82].

Additional file 2 of The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry

Hiba Mohammed Taha, Reza Aalizadeh, Nikiforos Alygizakis, Jean-Philippe Antignac, Hans Peter H. Arp, Richard Bade, Nancy Baker, Lidia Belova, Lubertus Bijlsma, Evan E. Bolton, Werner Brack, Alberto Celma, Wen-Ling Chen, Tiejun Cheng, Parviel Chirsir, Ľuboš Čirka, Lisa A. D’Agostino, Yannick Djoumbou Feunang, Valeria Dulio, Stellan Fischer, Pablo Gago-Ferrero, Aikaterini Galani, Birgit Geueke, Natalia Głowacka, Juliane Glüge … & Emma L. Schymanski
Additional file 2: Overview of the NORMAN-SLE website (DOCX format) as of 30 May 2022 [82].

Additional file 3 of Lost in explanation: internal conflicts in the discourse of ADHD psychoeducation

Myrte J. M. van Langen, Rebeka Szőke, Dominique N. J. Rijkelijkhuizen, Sarah Durston & Branko M. van Hulst
Additional file 3. Examples of internal conflicts in ADHD psychoeducation.

Additional file 1 of Evidence for pharmacological interventions to reduce cardiovascular risk for patients with chronic kidney disease: a study protocol of an evidence map

Julia M. T. Colombijn, Demy L. Idema, Kim van der Braak, Rene Spijker, Sabine C. A. Meijvis, Michiel L. Bots, Lotty Hooft, Marianne C. Verhaar & Robin W. M. Vernooij
Additional file 1: Appendix 1. search strategy in ClinicalTrials.gov. Appendix 2. search strategy for validation study.

Additional file 1 of Evidence for pharmacological interventions to reduce cardiovascular risk for patients with chronic kidney disease: a study protocol of an evidence map

Julia M. T. Colombijn, Demy L. Idema, Kim van der Braak, Rene Spijker, Sabine C. A. Meijvis, Michiel L. Bots, Lotty Hooft, Marianne C. Verhaar & Robin W. M. Vernooij
Additional file 1: Appendix 1. search strategy in ClinicalTrials.gov. Appendix 2. search strategy for validation study.

How Streptococcus suis escapes antibiotic treatments

Cristina Uruén, Carla García, Lorenzo Fraile, Jan Tommassen & Jesús Arenas
Abstract Streptococcus suis is a zoonotic agent that causes sepsis and meningitis in pigs and humans. S. suis infections are responsible for large economic losses in pig production. The lack of effective vaccines to prevent the disease has promoted the extensive use of antibiotics worldwide. This has been followed by the emergence of resistance against different classes of antibiotics. The rates of resistance to tetracyclines, lincosamides, and macrolides are extremely high, and resistance has spread...

Snacking for a reason: detangling effects of socio-economic position and stress on snacking behaviour

Marleen Gillebaart, Caroline Schlinkert, Maartje P. Poelman, Jeroen S. Benjamins & Denise T.D. De Ridder
Abstract Background As snacking can be considered a cornerstone of an unhealthy diet, investigating psychological drivers of snacking behaviour is urgent, and therefore the purpose of this study. Socio-economic position (SEP) and stress are known to affect many behaviours and outcomes, and were therefore focal points in the study. Methods In a cross-sectional survey study, we examined whether Socio-economic position (SEP) would amplify associations between heightened stress levels and self-reported negative-affect related reasons for snacking....

A qualitative evaluation of the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R) by the patient community: a web-based cross-sectional survey

Danielle Boyce, Michael Robinson, Jesse M. Cedarbaum, Lisa M. Shank, Christopher J. McDermott & Ruben P. A. van Eijk
Objective: The revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) is the most commonly used outcome measure in ALS studies. The aim of this study was to identify potential limitations of the ALSFRS-R from the perspective of people living with ALS and their caregivers. Methods: A web-based survey was developed by investigators, people living with ALS, and their caregivers, and shared across social media. For each item, participants were asked, “Can you think of a...

The reimbursement for expensive medicines: stakeholder perspectives on the SMA medicine nusinersen and the Dutch Coverage Lock policy

Féline E. V. Scheijmans, Margot L. Zomers, Sina Fadaei, Marthe R. Onrust, Rieke van der Graaf, Johannes J. M. van Delden, W. Ludo van der Pol & Ghislaine J. M. W. van Thiel
Abstract Background The reimbursement for expensive medicines poses a growing challenge to healthcare worldwide. In order to increase its control over the costs of medicines, the Dutch government introduced the Coverage Lock (CL) policy in 2015. The CL postpones decisions regarding reimbursement of expensive medicines until detailed advice on i.e., cost-effectiveness has been given. The CL has been in place for six years, has raised many questions and concerns, but currently, no evaluation is known...

Chemotherapy induces ACE2 expression in breast cancer via the ROS-AKT-HIF-1α signaling pathway: a potential prognostic marker for breast cancer patients receiving chemotherapy

Xiaoyan Zuo, Sixin Ren, He Zhang, Jianfei Tian, Ruinan Tian, Baoai Han, Hui Liu, Qian Dong, Zhiyong Wang, Yanfen Cui, Ruifang Niu & Fei Zhang
Abstract Background Angiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin-angiotensin system and a well-known functional receptor for the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into host cells. The COVID-19 pandemic has brought ACE2 into the spotlight, and ACE2 expression in tumors and its relationship with SARS-COV-2 infection and prognosis of cancer patients have received extensive attention. However, the association between ACE2 expression and tumor therapy and prognosis, especially in...

Additional file 2 of Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study

Joeri W. van Straalen, Sytze de Roock, Gabriella Giancane, Alessandro Consolaro, Marite Rygg, Ellen B. Nordal, Nadina Rubio-Pérez, Marija Jelusic, Jaime De Inocencio, Jelena Vojinovic, Nico M. Wulffraat, Patricia C. J. Bruijning-Verhagen, Nicolino Ruperto & Joost F. Swart
Additional file 2. Characteristics of included and excluded patients.

Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study

Joeri W. van Straalen, Sytze de Roock, Gabriella Giancane, Alessandro Consolaro, Marite Rygg, Ellen B. Nordal, Nadina Rubio-Pérez, Marija Jelusic, Jaime De Inocencio, Jelena Vojinovic, Nico M. Wulffraat, Patricia C. J. Bruijning-Verhagen, Nicolino Ruperto & Joost F. Swart
Abstract Background Etanercept (ETN) and adalimumab (ADA) are considered equally effective biologicals in the treatment of arthritis in juvenile idiopathic arthritis (JIA) but no studies have compared their impact on patient-reported well-being. The objective of this study was to determine whether ETN and ADA have a differential effect on patient-reported well-being in non-systemic JIA using real-world data. Methods Biological-naive patients without a history of uveitis were selected from the international Pharmachild registry. Patients starting ETN...

Additional file 4 of Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study

Joeri W. van Straalen, Sytze de Roock, Gabriella Giancane, Alessandro Consolaro, Marite Rygg, Ellen B. Nordal, Nadina Rubio-Pérez, Marija Jelusic, Jaime De Inocencio, Jelena Vojinovic, Nico M. Wulffraat, Patricia C. J. Bruijning-Verhagen, Nicolino Ruperto & Joost F. Swart
Additional file 4. Stacked histograms of time intervals between start of etanercept/adalimumab therapy and baseline/follow-up measurements.

Additional file 2 of Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort

Frank W. Roemer, Mylène Jansen, Anne C. A. Marijnissen, Ali Guermazi, Rafael Heiss, Susanne Maschek, Agnes Lalande, Francisco J. Blanco, Francis Berenbaum, Lotte A. van de Stadt, Margreet Kloppenburg, Ida K. Haugen, Christoph H. Ladel, Jaume Bacardit, Anna Wisser, Felix Eckstein, Floris P. J. G. Lafeber, Harrie H. Weinans & Wolfgang Wirth
Additional file 2.

Additional file 1 of A literature review exploring how health systems respond to acute shocks in fragile and conflict-affected countries

Kyaw Myat Thu, Sarah Bernays & Seye Abimbola
Supplementary Material 1

Epigenome-wide association studies of occupational exposure to benzene and formaldehyde

Rachael V. Phillips, Linqing Wei, Andres Cardenas, Alan E. Hubbard, Cliona M. McHale, Roel Vermeulen, Hu Wei, Martyn T. Smith, Luoping Zhang, Qing Lan & Nathaniel Rothman
Sufficient evidence supports a relationship between certain myeloid neoplasms and exposure to benzene or formaldehyde. DNA methylation could underlie benzene- and formaldehyde-induced health outcomes, but data in exposed human populations are limited. We conducted two cross-sectional epigenome-wide association studies (EWAS), one in workers exposed to benzene and another in workers exposed to formaldehyde. Using HumanMethylation450 BeadChips, we investigated differences in blood cell DNA methylation among 50 benzene-exposed subjects and 48 controls, and among 31 formaldehyde-exposed...

Poisoning in older adults: characterization of exposures reported to the Dutch Poisons Information Center

Saskia J. Rietjens, Joyce E. M. van der Heijden & Dylan W. de Lange
Introduction: The annual number of patients > 65 years old about whom the Dutch Poisons Information Center (DPIC) was consulted has more than doubled in the last decade. We aimed to gain insight in the type and circumstances of exposures reported to the DPIC involving older patients, in order to help prevent future poisonings. Methods: Enquiries to the DPIC involving patients > 65 years old were prospectively included from January 2019 to June 2019. Data...

Additional file 1 of Translation and validation of the Dutch Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ2.0) to evaluate health-related quality of life in patients with symptomatic spinal metastases

Roxanne Gal, Joanne M van der Velden, Daimy C Bach, Jorrit-Jan Verlaan, Ruth E Geuze, Joost PHJ Rutges, Helena M Verkooijen & Anne L Versteeg
Additional file 1. Final version of the Dutch Spine Oncology Study Group Outcomes Questionnaire 2.0 (SOSGOQ2.0).

Additional file 4 of In pursuit of a better transition to selected residencies: a quasi-experimental evaluation of a final year of medical school dedicated to the acute care domain

Gersten Jonker, Eveline Booij, Jacqueline E. M. Vernooij, Cor J. Kalkman, Olle ten Cate & Reinier G. Hoff
Additional file 4.

Additional file 1 of Nitrogen, manganese, iron, and carbon resource acquisition are potential functions of the wild rice Oryza rufipogon core rhizomicrobiome

Jingjing Chang, Lei Tian, Marcio F.A. Leite, Yu Sun, Shaohua Shi, Shangqi Xu, Jilin Wang, Hongping Chen, Dazhou Chen, Jianfeng Zhang, Chunjie Tian & Eiko E. Kuramae
Additional file 1: Table S1. Statistics for the quality assessment of the sequencing data.

Additional file 4 of Nitrogen, manganese, iron, and carbon resource acquisition are potential functions of the wild rice Oryza rufipogon core rhizomicrobiome

Jingjing Chang, Lei Tian, Marcio F.A. Leite, Yu Sun, Shaohua Shi, Shangqi Xu, Jilin Wang, Hongping Chen, Dazhou Chen, Jianfeng Zhang, Chunjie Tian & Eiko E. Kuramae
Additional file 4: Figure S2. The principal coordinate analysis (PCoA) of the (A) bacterial and (B) fungal communities in the rhizosphere of wild rice populations of the in situ natural reserves (ZTI, Zhangtang; AJSI, Anjiashan; STSI, Shuitaoshu) and ex situ (ZT, Zhangtang; AJS, Anjiashan; STS, Shuitaoshu).

Additional file 5 of In pursuit of a better transition to selected residencies: a quasi-experimental evaluation of a final year of medical school dedicated to the acute care domain

Gersten Jonker, Eveline Booij, Jacqueline E. M. Vernooij, Cor J. Kalkman, Olle ten Cate & Reinier G. Hoff
Additional file 5.

Nitrogen, manganese, iron, and carbon resource acquisition are potential functions of the wild rice Oryza rufipogon core rhizomicrobiome

Jingjing Chang, Lei Tian, Marcio F.A. Leite, Yu Sun, Shaohua Shi, Shangqi Xu, Jilin Wang, Hongping Chen, Dazhou Chen, Jianfeng Zhang, Chunjie Tian & Eiko E. Kuramae
Abstract Background The assembly of the rhizomicrobiome, i.e., the microbiome in the soil adhering to the root, is influenced by soil conditions. Here, we investigated the core rhizomicrobiome of a wild plant species transplanted to an identical soil type with small differences in chemical factors and the impact of these soil chemistry differences on the core microbiome after long-term cultivation. We sampled three natural reserve populations of wild rice (i.e., in situ) and three populations...

Additional file 2 of In pursuit of a better transition to selected residencies: a quasi-experimental evaluation of a final year of medical school dedicated to the acute care domain

Gersten Jonker, Eveline Booij, Jacqueline E. M. Vernooij, Cor J. Kalkman, Olle ten Cate & Reinier G. Hoff
Additional file 2.

Registration Year

  • 2022
    220

Resource Types

  • Text
    121
  • Collection
    48
  • Dataset
    47
  • Audiovisual
    2
  • Image
    2

Affiliations

  • Utrecht University
    220
  • University Medical Center Utrecht
    90
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    42
  • Shanghai Jiao Tong University
    32
  • Leiden University Medical Center
    27
  • Zhejiang University
    24
  • Newcastle University
    21
  • Universitätsklinikum Erlangen
    20
  • Hôpital Saint-Antoine
    20
  • University of A Coruña
    20