3 Works

Data from: Frequency and characteristics of MODY 1 (HNF4A mutation) and MODY 5 (HNF1B mutation) - Analysis from the DPV database

Katharina Warncke, Sebastian Kummer, Klemens Raile, Jürgen Grulich-Henn, Joachim Woelfle, Elisabeth Steichen, Nicole Prinz & Reinhard W. Holl
Objective. To characterize initial presentation and clinical course of patients with hepatocyte nuclear factor (HNF) 4A- and HNF1B-MODY in a multinational registry. Design, setting and participants. Within the Diabetes Patienten Verlaufsdokumentation (DPV) registry, 44 patients with HNF4A- and 35 patients with HNF1B-MODY were characterized and compared with patients < 20years old with type 1 diabetes (T1D)/type 2 diabetes (T2D). Main outcome measure. Clinical and laboratory parameters, therapy, metabolic control, and extrapancreatic symptoms in patients with...

Data from: Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

Vladimir Chubanov, Thomas Gudermann, Wenke Jonas, Annette Schürmann, Önder A Yildirim, Yuriy Shymkiv, Alexey G Ryazanov, Christian Weber, Emiel PC Van Der Vorst, Harald Bartsch, Karl Sotlar, Attila Braun, David G Simmons, Silvia Ferioli, Annika Wisnowsky, Banu Akdogan, Lorenz Mittermeier, Ludmila Sytik, Susanna Zierler & Vindi Jurinovic
Mg2+ regulates many physiological processes and signalling pathways. However, little is known about the mechanisms underlying the organismal balance of Mg2+. Capitalizing on a set of newly generated mouse models, we provide an integrated mechanistic model of the regulation of organismal Mg2+ balance during prenatal development and in adult mice by the ion channel TRPM6. We show that TRPM6 activity in the placenta and yolk sac is essential for embryonic development. In adult mice, TRPM6...

Data from: Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood

Nicole Toepfner, Christoph Herold, Oliver Otto, Philipp Rosendahl, Angela Jacobi, Martin Kräter, Julia Stächele, Leonard Menschner, Maik Herbig, Laura Ciuffreda, Lisa Ranford-Cartwright, Michal Grzybek, Ünal Coskun, Elisabeth Reithuber, Genevieve Garriss, Peter Mellroth, Birgitta Henriques Normark, Nicola Tregay, Meinolf Suttorp, Martin Bornhäuser, Edwin R. Chilvers, Reinhard Berner, Jochen Guck, Birgitta Henriques-Normark & Leonhard Menschner
Blood is arguably the most important bodily fluid and its analysis provides crucial health status information. A first routine measure to narrow down diagnosis in clinical practice is the differential blood count, determining the frequency of all major blood cells. What is lacking to advance initial blood diagnostics is an unbiased and quick functional assessment of blood that can narrow down the diagnosis and generate specific hypotheses. To address this need, we introduce the continuous,...

Registration Year

  • 2019
    1
  • 2018
    1
  • 2016
    1

Resource Types

  • Dataset
    3

Affiliations

  • German Center for Diabetes Research
    3
  • University of Würzburg
    1
  • Karolinska University Hospital
    1
  • Princeton Medical Institute
    1
  • University of Queensland
    1
  • University of Glasgow
    1
  • University of Cambridge
    1
  • Technical University Munich
    1
  • German Centre for Cardiovascular Research
    1
  • University of Ulm
    1