142 Works

Data from: Evolution and biogeography of Memecylon

Prabha Amarasinghe, Sneha Joshi, Navendu Page, Lahiru S. Wijedasa, Mary Merello, Hashendra Kathriarachchi, Robert Douglas Stone, Walter Judd, Ullasa Kodandaramaiah & Nico Cellinese
Premise The woody plant group Memecylon (Melastomataceae) is a large clade occupying diverse forest habitats in the Old World tropics and exhibiting high regional endemism. Its phylogenetic relationships have been previously studied using ribosomal DNA with extensive sampling from Africa and Madagascar. However, divergence times, biogeography, and character evolution of Memecylon remain uninvestigated. We present a phylogenomic analysis of Memecylon to provide a broad evolutionary perspective of this clade. Methods One hundred supercontigs of 67...

Bioprospecting of endophytic actinobacterium associated with Aloe ferox mill for antibacterial activity

Tsolanku Sidney Maliehe, Melusi Mbambo, Londeka Sibusisiwe Ngidi, Jabulani Siyabonga Emmanuel Shandu, Ofentse Jacob Pooe, Peter Masoko & Tlou Nelson Selepe
Abstract Background The emergence of drug resistance among pathogens has resulted in renewed interest in bioprospecting for natural microbial products. Methods This study aimed to bioprospecting endophytic actinobacterium associated with Aloe ferox Mill for its antibacterial activity. Endophytic actinomycetes were isolated from the gel of A. ferox Mill by surface sterilization technique using actinomycete isolation agar. The isolate with a promising antibacterial activity was identified using 16S rRNA sequence analysis. The minimum inhibitory concentration (MIC)...

The use of multisource spatial data for determining the proliferation of stingless bees in Kenya

David Masereti Makori, Elfatih M. Abdel-Rahman, Nelly Ndungu, John Odindi, Onisimo Mutanga, Tobias Landmann, Henri E. Z. Tonnang & Nkoba Kiatoko
Stingless/meliponine bees are eusocial insects whose polylactic nature enables interaction with a wide variety of wild plants and crops that enhance pollination and, hence, support ecosystem services. However, their true potential regarding pollination services and honey production is yet to be fully recognized. Worldwide, there are over 800 species of meliponine bees, with over 20 species documented on the African continent. Out of these, only 12 species have been well documented in Kenya. Moreover, interest...

Barriers and facilitators to HIV prevention interventions for reducing risky sexual behavior among youth worldwide: a systematic review

Fungai Mbengo, Esther Adama, Amanda Towell-Barnard, Arvin Bhana & Maggie Zgambo
Abstract Background Interventions aimed at reducing risky sexual behavior are considered an important strategy for averting Human Immunodeficiency Virus (HIV) infection among youth (15–24 years) who continue to be at risk of the disease. Enhancing intervention success requires a comprehensive understanding of the barriers and facilitators to interventions targeting youth. However, there is lack of a systematic review of both quantitative and qualitative studies to comprehensively identify and synthesize barriers and facilitators to HIV prevention...

Barriers and facilitators to HIV prevention interventions for reducing risky sexual behavior among youth worldwide: a systematic review

Fungai Mbengo, Esther Adama, Amanda Towell-Barnard, Arvin Bhana & Maggie Zgambo
Abstract Background Interventions aimed at reducing risky sexual behavior are considered an important strategy for averting Human Immunodeficiency Virus (HIV) infection among youth (15–24 years) who continue to be at risk of the disease. Enhancing intervention success requires a comprehensive understanding of the barriers and facilitators to interventions targeting youth. However, there is lack of a systematic review of both quantitative and qualitative studies to comprehensively identify and synthesize barriers and facilitators to HIV prevention...

CTPS1 inhibition suppresses proliferation and migration in colorectal cancer cells

Fahong Wu, Yudong Mao, Tao Ma, Xiaoli Wang, Hangzhi Wei, Tianwei Wang, Jia Wang & Youcheng Zhang
Colorectal cancer (CRC) is now the third most prevalent tumor and one of the deadliest cancers worldwide, with an increasing prevalence every year. Therefore, we urgently need to understand the mechanisms regulating the progression of colorectal cancer and find potential diagnostic biomarkers. In this study, we performed an analysis using the TCGA and GEO databases to find a molecular biomarker for the diagnosis of CRC, namely CTPS1. The results of this analysis revealed that CTPS1...

Additional file 1 of Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Additional file 1. Supporting methods documents. PRISMA-P and PRISMA-IPD checklists, database search strategies, manuscript screening form, risk of bias instrument, and strength of evidence tool.

Additional file 2 of Dietary patterns and childhood stunting in Zimbabwe

Anesu Marume, Moherndran Archary & Saajida Mahomed
Supplementary Material 2

sj-docx-1-cat-10.1177_10760296221132551 - Supplemental material for Prescribing Trends of Oral Anticoagulants from 2010 to 2020 in Shanghai, China: A Retrospective Study

Chi Zhang, Jia Wang, Ya Yang, Er-Li Ma, Hou-Wen Lin, Bing-Long Liu & Zhi-Chun Gu
Supplemental material, sj-docx-1-cat-10.1177_10760296221132551 for Prescribing Trends of Oral Anticoagulants from 2010 to 2020 in Shanghai, China: A Retrospective Study by Chi Zhang, Jia Wang, Ya Yang, Er-Li Ma, Hou-Wen Lin, Bing-Long Liu and Zhi-Chun Gu in Clinical and Applied Thrombosis/Hemostasis

Prevalence and molecular characterization of alpha and beta-Thalassemia mutations among Hakka people in southern China

XiangXing Zeng, ZhiFang Liu, CaiHua He, Jia Wang & LiXiang Yan
Abstract Our aim was to investigate molecular features of thalassemia for proper clinical consultation and prevention in Heyuan. In our research, a total of 25,437 positive screening subjects were further subjected to a genetic analysis of α-thalassemia (α-thal) and β-thalassemia (β-thal). The deletion of α-thal mutation was tested by Gap-PCR, while the non-deletion of α-thal and β-thal mutation were identified by the PCR-reverse dot blot (PCR-RDB) technique. Nested PCR detected Hkαα/-- SEA and Hkαα/αα. Among...

‘If I am playing football, I forget that I have this virus’: the challenges and coping strategies of adolescents with perinatally acquired HIV in KwaZulu-Natal, South Africa

Marian Loveday, Jennifer Furin, Sindisiwe Hlangu, Thabile Mthethwa & Tasneem Naidoo
Abstract Background Adolescents who have acquired HIV perinatally (ALHIV) face unique challenges in taking lifelong antiretroviral therapy (ART), but little is known about what factors affect their adherence over the course of their lifelong treatment journey. Methods We conducted a qualitative study with ALHIV who had periods of poor adherence to ART in KwaZulu-Natal, South Africa using Participant-generated Visual Methodologies (PVM). Participants used photography to represent their perspectives and experiences. Results 14 individuals participated in...

Patient journey and resources mapping to implement a praziquantel mass drug administration program for children aged 5 years and below in resource-limited settings

Mhlengi Vella Ncube, Muhubiri Kabuyaya & Moses John Chimbari
Abstract Background The early childhood development of millions of children in some low- and medium-income countries may be compromised by schistosomiasis infections contracted at the age of 5 years and below. Currently, there are no standard guidelines for treating schistosomiasis in children that are 5 years and younger using praziquantel (PZQ), the only drug that the World Health Organization (WHO) recommends for treating schistosomiasis. The review is on processes and resources involved in the treatment...

Additional file 3 of Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Additional file 3. Code and data. IPD from co-authors who agreed to share it, results of all analyses presented in the paper, and R code files necessary to reproduce the analysis and figures.

Additional file 4 of Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Additional file 4. Concentration and forest plots for each individual immune mediator. Concentration plots - Each symbol shows the concentration of the indicated immune mediator in a single sample. Each study is plotted separately. Lines connect samples from the same participant; in some cases participants provided multiple samples in the same phase, in which case multiple symbols within the same phase may be connected. Pale grey symbols are below the lower limit of detection and...

Additional file 5 of Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Additional file 5: Figure S1. Assessment of publication bias. A Funnel plots. Symbols show the effect of the menstrual cycle (x-axis) and the standard error of that effect (y-axis, reversed). Each symbol shows an individual study. Vertical solid line shows no effect. Vertical dashed line shows the meta-estimate of effect. Diagonal dashed lines enclose the region expected to include 95% of studies based on the estimated meta-effect and the standard errors. B Results of Egger’s...

Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Abstract Background Hormonal changes during the menstrual cycle play a key role in shaping immunity in the cervicovaginal tract. Cervicovaginal fluid contains cytokines, chemokines, immunoglobulins, and other immune mediators. Many studies have shown that the concentrations of these immune mediators change throughout the menstrual cycle, but the studies have often shown inconsistent results. Our understanding of immunological correlates of the menstrual cycle remains limited and could be improved by meta-analysis of the available evidence. Methods...

A healthcare workers’ mHealth adoption instrument for the developing world

Michael Addotey-Delove, Richard E. Scott & Maurice Mars
Abstract Introduction Healthcare workers’ adoption of mHealth is critical to the success or failure of clinician based mHealth services in the developing world. mHealth adoption is affected or promoted by certain factors, some of which are peculiar to the developing world. Identifying these factors and evaluating them will help develop a valid and reliable measuring instrument for more successful prediction of mHealth adoption in the future. The aim of this study was to design and...

Additional file 2 of Barriers and enablers to emergency obstetric and newborn care services use in Wolaita Zone, Southern Ethiopia: a qualitative case study

Mihiretu Alemayehu, Bereket Yakob & Nelisiwe Khuzwayo
Additional file 2: COREQ (COnsolidated criteria for REporting Qualitative research) Checklist.

Additional file 1 of Barriers and enablers to emergency obstetric and newborn care services use in Wolaita Zone, Southern Ethiopia: a qualitative case study

Mihiretu Alemayehu, Bereket Yakob & Nelisiwe Khuzwayo
Additional file 1: Information sheet, consent to participate in research, and interview guide.

Barriers and enablers to emergency obstetric and newborn care services use in Wolaita Zone, Southern Ethiopia: a qualitative case study

Mihiretu Alemayehu, Bereket Yakob & Nelisiwe Khuzwayo
Abstract Background Globally, 11.4 million untreated obstetric complications did not receive Emergency Obstetric and Newborn Care (EmONC) services yearly, with the highest burden in low and middle-income countries. Half of the Ethiopian women with obstetric complications did not receive EmONC services. However, essential aspects of the problem have not been assessed in depth. This study, therefore, explored the various aspects of barriers and enablers to women’s EmONC services utilization in southern Ethiopia. Methodology A qualitative...

Additional file 2 of An analysis of past and future heatwaves based on a heat-associated mortality threshold: towards a heat health warning system

Thandi Kapwata, Michael T. Gebreslasie & Caradee Y. Wright
Additional file 2. Heatwave characteristics from 2014 - 2019 as defined using threshold of 12.8 oC and duration of two days or more.

Additional file 2 of An analysis of past and future heatwaves based on a heat-associated mortality threshold: towards a heat health warning system

Thandi Kapwata, Michael T. Gebreslasie & Caradee Y. Wright
Additional file 2. Heatwave characteristics from 2014 - 2019 as defined using threshold of 12.8 oC and duration of two days or more.

Additional file 4 of An analysis of past and future heatwaves based on a heat-associated mortality threshold: towards a heat health warning system

Thandi Kapwata, Michael T. Gebreslasie & Caradee Y. Wright
Additional file 4. Heatwave characteristics for period 2020 – 2039 using data simulated from RCP 8.5 projections.

Modelling dominant height growth including a rainfall effect using the algebraic difference approach

Morries Chauke, Henry Mwambi & Heyns Kotze
ABSTRACT Background: Estimating forest productivity is critical for effective management and site assessment. The dominant height is used to calculate the Site Index (SI), which is commonly used to assess forest productivity. In this study, an algebraic difference approach was used to develop a dominant height model incorporating the rainfall effect for Eucalyptus grandis x Eucalyptus urophylla ( E. Grandis x E. Urophylla). The dataset consists of 75 permanent sample plots ranging in age from...

Additional file 2 of Prognostic markers in patients with chronic lymphocytic leukaemia on targeted therapy, chemoimmunotherapy with anti-CD20 monoclonal antibody: a systematic review and meta-analysis of prognostic factors

Zekhethelo A. Mkhwanazi, Tawanda M. Nyambuya, Snenhlanhla A. Mfusi & Bongani B. Nkambule
Additional file 2: Supplementary Table 2. Risk of bias assessment of individual studies using the QUIPS tool.

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  • 2022
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Affiliations

  • University of KwaZulu-Natal
    142
  • Jiangsu Academy of Agricultural Sciences
    27
  • Zhejiang University
    27
  • Jilin University
    27
  • Inner Mongolia Agricultural University
    27
  • Southwest University
    27
  • Oak Ridge National Laboratory
    27
  • Peking University
    27
  • Second Hospital of Shanxi Medical University
    25
  • Harvard University
    21