ABSTRACT Introduction: Knockdown of fat mass and obesity-associated gene (FTO) can induce N6-methyladenosine (m 6A) ribonucleic acid (RNA) methylation. The objective of this study was to explore the effect of m 6A RNA methylation on atherosclerotic vulnerable plaque by FTO knockdown. Methods: A total of 50 New Zealand white rabbits were randomly divided into pure high-fat group, sham operation group, vulnerable plaque group, empty load group, and FTO knockdown group (10 rabbits/group). Results: Flow cytometry...

Abstract As one of the most promising formulations for poorly water-soluble drugs, nanocrystals have been attracting increasing attention in recent years. Isoliquiritigenin (ISL) is a flavonoid with a chalcone structure, and possesses many biological activities. However, its clinical application is significantly limited mainly due to its low oral bioavailability caused by poor hydrophilicity. To address this, ISL nanocrystals were developed in this study to improve its oral bioavailability. Three types of nanocrystals with differing particle...

The receptor-interacting serine/threonine protein kinase 1 (RIPK1) is tightly related to Digestive System Neoplasms genesis. Therefore, inhibitors that target RIPK1 have gained popularity in today's anti-cancer therapy. Molecular docking, molecular dynamics simulations, and molecular mechanics/Poisson-Boltzmann surface area calculations were used to investigate the binding mode and inhibition mechanism of five 4,5-dihydropyrazole derivatives with RIPK1 in the present work. The results showed that the five inhibitors mainly interacted with RIPK1 through van der Waals interaction and...

Supplemental material, sj-docx-1-nad-10.1177_14550725231160335 for The public-private decision for alcohol retail systems: Examining the economic, health, and social impacts of alternative systems in Finland by Adam Sherk, Tim Stockwell, Justin Sorge, Samuel Churchill, Colin Angus, Tanya Chikritzhs, John Holmes, Petra Meier, Timothy S. Naimi, Thor Norström, Mats Ramstedt and Jussi Simpura in Nordic Studies on Alcohol and Drugs

The receptor-interacting serine/threonine protein kinase 1 (RIPK1) is tightly related to Digestive System Neoplasms genesis. Therefore, inhibitors that target RIPK1 have gained popularity in today's anti-cancer therapy. Molecular docking, molecular dynamics simulations, and molecular mechanics/Poisson-Boltzmann surface area calculations were used to investigate the binding mode and inhibition mechanism of five 4,5-dihydropyrazole derivatives with RIPK1 in the present work. The results showed that the five inhibitors mainly interacted with RIPK1 through van der Waals interaction and...

Nucleotide variants were called using GATK version 3.8 with the coho salmon RefSeq genome assembly GCF_002021735.2 (GenBank assembly accession GCA_002021735.2). Samples were from the following NCBI BioProjects: PRJNA401427 and PRJNA808051.

Geographic distinctions in the affinity of tree populations for select ectomycorrhizal fungi (EMF) may occur where strong edaphic pressures act on fungal communities and their hosts. We examine this premise for Pseudotsuga menziesii var. menziesii of southwest British Columbia, using ten native seedlots collected from a range of mean annual precipitation (MAP), as a proxy for podzolization extent and phosphorus (P) deficiencies, and evaluated in contrasting low P and high P soils. After two growing...

Supplemental material, sj-docx-1-nad-10.1177_14550725231160335 for The public-private decision for alcohol retail systems: Examining the economic, health, and social impacts of alternative systems in Finland by Adam Sherk, Tim Stockwell, Justin Sorge, Samuel Churchill, Colin Angus, Tanya Chikritzhs, John Holmes, Petra Meier, Timothy S. Naimi, Thor Norström, Mats Ramstedt and Jussi Simpura in Nordic Studies on Alcohol and Drugs

Nucleotide variants were called using GATK version 3.8 with the coho salmon RefSeq genome assembly GCF_002021735.2 (GenBank assembly accession GCA_002021735.2). Samples were from the following NCBI BioProjects: PRJNA401427 and PRJNA808051.

Background: Organising alcohol retail systems with more or less public ownership has implications for health and the economy. The aim of the present study was to estimate the economic, health, and social impacts of alcohol use in Finland in 2018 (baseline), and in two alternative scenarios in which current partial public ownership of alcohol retail sales is either increased or fully privatised. Methods: Baseline alcohol-attributable harms and costs were estimated across five categories of death,...

Supplemental material, sj-docx-1-pcr-10.1177_26323524231156944 for ‘The beauty and the less beautiful’: exploring the meanings of dying at ‘home’ among community and practitioner representatives and advocates across Canada by Laura Funk, Marian Krawczyk, Maria Cherba, S. Robin Cohen, Carren Dujela, Camille Nichols and Kelli Stajduhar in Palliative Care and Social Practice

Background:Significant structural and normative pressures privilege the ideal of dying at home in Canada. At the same time, the social complexities and meanings associated with dying in particular locations remain critically unexamined.Objective:The aim of this study is to explore how diverse community members, including health and social care stakeholders, talk about preferences for locations of dying, with a particular focus on meanings of dying at home.Design:Semi-structured virtual interviews were conducted with 24 community and practitioner...

Background:Significant structural and normative pressures privilege the ideal of dying at home in Canada. At the same time, the social complexities and meanings associated with dying in particular locations remain critically unexamined.Objective:The aim of this study is to explore how diverse community members, including health and social care stakeholders, talk about preferences for locations of dying, with a particular focus on meanings of dying at home.Design:Semi-structured virtual interviews were conducted with 24 community and practitioner...

Two new indole alkaloids, naucleamide H (1) and (±)-19-O-butylangustoline (8), along with seven known alkaloids, 3,14-dihydroangustine (2), (-)-naucleofficine D (3a), (+)-naucleofficine D (3b), nauclefine (4), angustidine (5),19-O-ethylangustoline (6) and angustine (7) were isolated from the water extract of Nauclea officinalis. The structures of these compounds were established by spectroscopic analysis. Among them, the cytotoxicity of 1, 2, 6 and 8 were evaluated against six human cancer cell lines (HepG-2, SKOV3, HeLa, SGC 7901, MCF-7 and...

Abstract As one of the most promising formulations for poorly water-soluble drugs, nanocrystals have been attracting increasing attention in recent years. Isoliquiritigenin (ISL) is a flavonoid with a chalcone structure, and possesses many biological activities. However, its clinical application is significantly limited mainly due to its low oral bioavailability caused by poor hydrophilicity. To address this, ISL nanocrystals were developed in this study to improve its oral bioavailability. Three types of nanocrystals with differing particle...

Background: Organising alcohol retail systems with more or less public ownership has implications for health and the economy. The aim of the present study was to estimate the economic, health, and social impacts of alcohol use in Finland in 2018 (baseline), and in two alternative scenarios in which current partial public ownership of alcohol retail sales is either increased or fully privatised. Methods: Baseline alcohol-attributable harms and costs were estimated across five categories of death,...

Two new indole alkaloids, naucleamide H (1) and (±)-19-O-butylangustoline (8), along with seven known alkaloids, 3,14-dihydroangustine (2), (-)-naucleofficine D (3a), (+)-naucleofficine D (3b), nauclefine (4), angustidine (5),19-O-ethylangustoline (6) and angustine (7) were isolated from the water extract of Nauclea officinalis. The structures of these compounds were established by spectroscopic analysis. Among them, the cytotoxicity of 1, 2, 6 and 8 were evaluated against six human cancer cell lines (HepG-2, SKOV3, HeLa, SGC 7901, MCF-7 and...

ABSTRACT Introduction: Knockdown of fat mass and obesity-associated gene (FTO) can induce N6-methyladenosine (m 6A) ribonucleic acid (RNA) methylation. The objective of this study was to explore the effect of m 6A RNA methylation on atherosclerotic vulnerable plaque by FTO knockdown. Methods: A total of 50 New Zealand white rabbits were randomly divided into pure high-fat group, sham operation group, vulnerable plaque group, empty load group, and FTO knockdown group (10 rabbits/group). Results: Flow cytometry...

Supplemental material, sj-docx-1-pcr-10.1177_26323524231156944 for ‘The beauty and the less beautiful’: exploring the meanings of dying at ‘home’ among community and practitioner representatives and advocates across Canada by Laura Funk, Marian Krawczyk, Maria Cherba, S. Robin Cohen, Carren Dujela, Camille Nichols and Kelli Stajduhar in Palliative Care and Social Practice