There is an increased recognition of the need to identify and quantify the impact of genetic polymorphisms on drug-drug interactions. This study investigated the pharmacogenetics of the pharmacokinetic drug-drug interaction between nevirapine and artemether-lumefantrine in HIV-positive and HIV-negative adult Nigerian subjects. Thirty each of HIV-infected patients on nevirapine-based antiretroviral therapy and HIV-negative volunteers without clinical malaria, but with predetermined CYP2B6 c.516GG and TT genotypes were administered a complete treatment dose of 3-days of artemether-lumefantrine. Rich...

Supplementary Material 1

Additional file 2.

Abstract Background Oral diseases are features of COVID-19 infection. There is, however, little known about oral diseases associated with COVID-19 in adolescents and young adults (AYA). Therefore, the aim of this study was to assess oral lesions’ association with COVID-19 infection in AYA; and to identify if sex and age will modify these associations. Methodology Data was collected for this cross-sectional study between August 2020 and January 2021 from 11-to-23 years old participants in 43-countries...

Supplementary Material 2

Abstract Child and adolescent mental health (CAMH) are a global priority. Different countries across the globe face unique challenges in CAMH services that are specific to them. However, there are multiple issues that are also similar across countries. These issues have been presented in this commentary from the lens of early career CAMH professionals who are alumni of the Donald J Cohen Fellowship program of the IACAPAP. We also present recommendations that can be implemented...

Additional file 1. List of countries in West Africa number of respondents included in the analysis.

Supplementary Material 1

The bushmeat trade in tropical Africa represents illegal, unsustainable off-takes of millions of tons of wild game – mostly mammals – per year. We sequenced four mitochondrial gene fragments (cyt b, COI, 12S, 16S) in >300 bushmeat items representing nine mammalian orders and 59 morphological species from five western and central African countries (Guinea, Ghana, Nigeria, Cameroon and Equatorial Guinea). Our objectives were to assess the efficiency of cross-species PCR amplification and to evaluate the...

Background: Access to the right information from credible sources on sexual and reproductive health (SRH) issues is germane to smooth and healthy transition from childhood to adulthood among adolescents with or without disabilities. Despite the large amount of research focused on adolescents aged 15-19 years, adolescents with disabilities, particularly those with visual impairment have received little attention. This study aims to assess the sources of information on SRH issues among adolescents with visually impairment (AVI)...

Protected areas (PAs) are vital in the global effort to preserve biodiversity, particularly for disturbance-intolerant pollinator species in the tropics. As there is little information on the potential of PAs for pollinator conservation in sensitive tropical ecosystems, we assessed here insect pollinator diversity in protected vs. unprotected areas in two vegetation zones in Nigeria, within the West African Guinea Biodiversity Hotspot. We selected two land-use types based on predominant canopy cover type (open and tree-shaded...

Abstract Background The aim of this study was to determine whether self-reported depression, coronavirus disease of 2019 (COVID-19) health risk profile, HIV status, and SARS-CoV-2 exposure were associated with the use of COVID-19 prevention measures. Methods This survey collected data electronically between June 29 and December 31, 2020 from a convenient sample of 5050 adults 18 years and above living in 12 West African countries. The dependent variables were: social distancing, working remotely, difficulty obtaining...

Abstract Background The aim of this study was to determine whether self-reported depression, coronavirus disease of 2019 (COVID-19) health risk profile, HIV status, and SARS-CoV-2 exposure were associated with the use of COVID-19 prevention measures. Methods This survey collected data electronically between June 29 and December 31, 2020 from a convenient sample of 5050 adults 18 years and above living in 12 West African countries. The dependent variables were: social distancing, working remotely, difficulty obtaining...

Additional file 1.

Abstract Background Oral diseases are features of COVID-19 infection. There is, however, little known about oral diseases associated with COVID-19 in adolescents and young adults (AYA). Therefore, the aim of this study was to assess oral lesions’ association with COVID-19 infection in AYA; and to identify if sex and age will modify these associations. Methodology Data was collected for this cross-sectional study between August 2020 and January 2021 from 11-to-23 years old participants in 43-countries...

Introduction: Inflammation plays a major role in the development of atherosclerosis and cardiovascular morbidity and mortality in chronic kidney disease (CKD) patients. Toll-like receptor-4 (TLR4) is a major receptor for lipopolysaccharides (endotoxin) and other ligands involved in the pathogenesis of inflammation. We determined whether endotoxin levels and the presence of TLR4 polymorphisms are associated with markers of inflammation and atherosclerosis among South African CKD patients. Materials and methods: Endotoxin, lipopolysaccharide binding protein (LBP), serum CD14...

Fire is a major disturbance factor in many terrestrial ecosystems, leading to landscape transformation in fire‐prone areas. Species in mutualistic interactions are often highly sensitive to disturbances like fire events, but the degree and complexity of their responses are unclear. We use bipartite insect–flower interaction networks across a recently burned landscape to explore how plant–pollinator interaction networks respond to a recent major fire event at the landscape level, and where fire refuges were present. We...

The Nigerian riparian forest ecosystems had declined in extent and distribution and this had been attributed mainly to land use change. This study intended to provide an understanding of the links between plant diversity, composition, structures, and disturbances both anthropogenic and natural processes inducing the vegetation dynamics. Nine study sites were used for this study, within each site, five (5) plots (0.25 ha in size) were marked out and placed systematically at an interval of...

Background: Double burden of malnutrition (DBM) is the co-existence of overweight/obesity and undernutrition. Rising prevalence rates of childhood overweight/obesity in Nigeria have been reported, whilst undernutrition continues to be prevalent. This study aimed to estimate the prevalence and distribution of underweight, stunting, thinness, overweight/obesity, and the DBM among school-aged children and adolescents in Gombe and Osun States in Nigeria. Methods: This was a community-based cross-sectional study carried out in Osun and Gombe States in 2019...

Research on fern ecology has gained attention in the last decade, yet there is a paucity of information on the comparison of ferns communities across continents. This study focused on comparing the ferns community assemblages in some tropical forests of Malaysia and Nigeria, thereby assessing the patterns of species richness (SR) and phylogenetic diversity(PD) in relation to the bioclimatic drivers across the continents. The diversity and taxonomic compositions of ferns were assessed using 180 plots...

Additional file 1. List of countries in West Africa number of respondents included in the analysis.

Supplementary Material 2

Additional file 1.