51 Works

Data from: Phylogenetic conservatism and biogeographic affinity influence woody plant species richness-climate relationships in eastern Eurasia

Xiangyan Su, Nawal Shrestha, Xiaoting Xu, Denis Sandanov, Qinggang Wang, Siyang Wang, Dimitar Dimitrov & Zhiheng Wang
Mechanisms underlying species richness patterns remain a central yet controversial issue in biology. Climate has been regarded as a major determinant of species richness. However, the relative influences of different evolutionary processes, (i.e. niche conservatism, diversification rate, and time for speciation) on species richness-climate relationships remain to be tested. Here, using newly compiled distribution maps for 11,422 woody plant species in eastern Eurasia, we estimated species richness patterns for all species and for families with...

Data from: Four myriapod relatives – but who are sisters? No end to debates on relationships among the four major myriapod subgroups

Nikolaus U. Szucsich, Daniela Bartel, Alexander Blanke, Alexander Böhm, Alexander Donath, Makiko Fukui, Simon Grove, Shanlin Liu, Oliver Macek, Ryuichiro Machida, Bernhard Misof, Yasutaka Nakagaki, Lars Podsiadlowski, Kaoru Sekiya, Shigekazu Tomizuka, Björn M. Von Reumont, Robert M. Waterhouse, Manfred Walzl, Guanliang Meng, Xin Zhou, Günther Pass & Karen Meusemann
Background: Phylogenetic relationships among the myriapod subgroups Chilopoda, Diplopoda, Symphyla and Pauropoda are still not robustly resolved. The first phylogenomic study covering all subgroups resolved phylogenetic relationships congruently to morphological evidence but is in conflict with most previously published phylogenetic trees based on diverse molecular data. Outgroup choice and long-branch attraction effects were stated as possible explanations for these incongruencies. In this study, we addressed these issues by extending the myriapod and outgroup taxon sampling...

Soil microbial legacy drives crop diversity advantage: linking ecological plant-soil feedback with agricultural intercropping

Guangzhou Wang, Shuikuan Bei, Jianpeng Li, Xingguo Bao, Jiudong Zhang, Peggy Schultz, Haigang Li, Long Li, Fusuo Zhang, James Bever & Junling Zhang
Although the importance of the soil microbiome in mediating plant community structures and functions has been increasingly emphasized in ecological studies, the biological processes driving crop diversity overyielding remain unexplained in agriculture. Based on the plant-soil feedback (PSF) theory and method, we quantified how much soil microbes contributed to intercropping overyielding and detected which microbial groups mediated this effect. Soils were collected as inocula and sequenced from a unique 10-year field experiment, consisting of monoculture,...

Phylogenomic analysis sheds light on the evolutionary pathways towards acoustic communication in Orthoptera

Hojun Song, Olivier Béthoux, Seunggwan Shin, Alexander Donath, Harald Letsch, Shanlin Liu, Duane D. McKenna, Guanliang Meng, Bernhard Misof, Lars Podsiadlowski, Xin Zhou, Benjamin Wipfler & Sabrina Simon
Acoustic communication is enabled by the evolution of specialised hearing and sound producing organs. In this study, we performed a large-scale macroevolutionary study to understand how both hearing and sound production evolved and affected diversification in the insect order Orthoptera, which includes many familiar singing insects, such as crickets, katydids, and grasshoppers. Using phylogenomic data, we firmly establish phylogenetic relationships among the major lineages and divergence time estimates within Orthoptera, as well as the lineage-specific...

Thioridazine hydrochloride: an antipsychotic agent that inhibits tumor growth and lung metastasis in triple-negative breast cancer via inducing G0/G1 arrest and apoptosis

Yanlin Song, Lu Li, Jiao Chen, Hongli Chen, Bomiao Cui, Yun Feng, Ping Zhang, Qiangsheng Zhang, Yong Xia & Min Luo
Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer and still lacks available targeted therapy options. Thioridazine hydrochloride (Thi-hyd), a common phenothiazine antipsychotic drug, has shown great tumor-suppressive potential in several types of cancer cells. In this study, we explored the anti-tumor effects of Thi-hyd on TNBC. Thi-hyd significantly inhibited the viability and migration of TNBC cells in vitro. PI3K/AKT signaling pathway was verified to be related to Thi-hyd-induced tumor inhibition. G0/G1...

MicroRNA-409-5p promotes retinal neovascularization in diabetic retinopathy

Ying Wang, Wenwen Lin & Jianghua Ju
Background: Retinal neovascularization, which is characterized by the increased proliferation, migration, and tube formation of retinal microvascular endothelial cells (RMECs), contributes to the progression of diabetic retinopathy (DR). MiR-409-5p has been reported to be upregulated in peripheral blood of DR patients and in vascular endothelial growth factor (VEGF)-induced RMECs. However, the role of miR-409-5p in retinal neovascularization of DR remains unelucidated. Method: The expression of miR-409-5p was measured in retinal tissues of streptozocin-induced and db/db...

Tranilast attenuates neuropathic pain during type-2 diabetes by inhibiting hypoxia-induced pro-inflammatory cytokines in Zucker diabetic fatty rat model

Wei Zhang, Jun Ma, Shan Wang, Tao Huang & Min Xia
The modulatory effect of tranilast on neuropathic pain in type-2 diabetes (T2DM) remains unclear. We monitored interleukin (IL)-1β, nuclear factor-κB (NF-κB) and tumour necrosis factor-α (TNF-α) levels during the progression of T2DM induced neuropathic pain in rats, and assessed the impact of tranilast treatment of increasing concentrations (0, 200 and 400 mg/kg/day via oral gavage in 1% NaHCO3 delivered as 100 mg/kg twice a day) on the levels of cytokine production, as well as on...

Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress

Fan Wang, Lin Liu, Yu Tong, Linfeng Li, Yanfeng Liu & Wei-Qiang Gao
Prostate cancer (PCa) is the second commonly diagnosed malignancy in men over the world. Although androgen deprivation therapy for advanced PCa patients has significantly improved their survival, the majority of these patients eventually develop castration-resistant prostate cancer (CRPC). Proscillaridin A (Pro A), a cardiac glycoside that is clinically used to treat various heart failure diseases, has been reported to have anticancer activity in several cancers. However, whether Pro A exerts an inhibitory effect on PCa...

Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial

Haichun Lai, Wei Huang, Wei Chen & Desheng Wang
Aim:Some obstructive sleep apnea (OSA) patients may have mandibular retrognathia (ANB > 4.7° and SNB < 76.2°). Currently, there are no studies that have compared the effectiveness of continuous positive airway pressure (CPAP) versus mandibular advancement device (MAD) in severe OSA patients with mandibular retrognathia. We explored the efficacy of CPAP versus MAD for the treatment of severe OSA patients with mandibular retrognathia.Methods:A total of 105 patients were enrolled. Outcomes were assessed by using polysomnography,...

Supplemental Material, CONSORT_a - Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial

Haichun Lai, Wei Huang, Wei Chen & Desheng Wang
Supplemental Material, CONSORT_a for Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial by Haichun Lai, Wei Huang, Wei Chen and Desheng Wang in Ear, Nose & Throat Journal

GIT1 overexpression promotes epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma

Guifu Wang, Xuesong Bai, Guoqing Jiang, Shengjie Jin, Qian Wang, Aoqing Wang, Rui Peng, Aiwu Ke & Dousheng Bai
Globally, hepatocellular carcinoma (HCC) is one of the most common causes of cancer-associated mortalities. It has a high rate of metastasis and recurrence, which predict a poor prognosis. G-protein-coupled receptor (GPCR)-kinase interacting protein-1 (GIT1) is a multifunctional scaffold protein that mediates the progression of various tumors. Studies have correlated GIT1 with HCC, however, these correlations have not been fully elucidated. Therefore, we aimed at evaluating the expression of GIT1 in HCC tissues and cells, and...

Development of an immune-related prognostic index associated with osteosarcoma

Chao-Dong Yin, Ying-Lan Hou, Xiao-Ren Liu, Yu-Sheng He, Xin-Ping Wang, Cheng-Jie Li, Xiao-Hong Tan & Jun Liu
Tumor immunity is closely associated with the prognosis of tumors, including osteosarcoma (OS). The aim of the present study was to construct an immune-related prognostic index (PI) to predict the prognosis of OS. Herein, OS expression data were sourced from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. We divided the OS patients into nonmetastatic and metastatic groups, allowing differentially immune-related genes (DIRGs) to be selected. After DIRGs were further investigated by enrichment...

Tomato Protein Phosphatase 2C (SlPP2C3) influences fruit ripening onset and fruit glossiness

Ping Leng
Abscisic acid (ABA) plays a vital role in coordinating physiological processes during fresh fruit ripening. ABA can bind to ABA receptors which interacts and inhibits their co-receptors type 2C phosphatases (PP2Cs). However, the dissected mechanism of PP2C during fruit ripening is unclear. In this study, we identify the role of SlPP2C3, a tomato type 2C phosphatase, as a negative regulator of ABA signaling and fruit ripening. SlPP2C3 selectively interacted with monomeric ABA receptors and SlSnRK2.8...

Supplemental Material, CONSORT_b - Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial

Haichun Lai, Wei Huang, Wei Chen & Desheng Wang
Supplemental Material, CONSORT_b for Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial by Haichun Lai, Wei Huang, Wei Chen and Desheng Wang in Ear, Nose & Throat Journal

Supplemental Material, sj-doc-1-ear-10.1177_0145561320974863 - Primary Heterotopic Meningioma of Nasal Cavity: Case Report and Literature Review

Xianwen Hu, Maoyan Jiang, Zelong Feng, Juan Wang, Pan Wang & Jiong Cai
Supplemental Material, sj-doc-1-ear-10.1177_0145561320974863 for Primary Heterotopic Meningioma of Nasal Cavity: Case Report and Literature Review by Xianwen Hu, Maoyan Jiang, Zelong Feng, Juan Wang, Pan Wang and Jiong Cai in Ear, Nose & Throat Journal

Crocin inhibits the activation of mouse hepatic stellate cells via the lnc-LFAR1/MTF-1/GDNF pathway

Ji Xuan, Dongmei Zhu, Zhengyuan Cheng, Yuping Qiu, Mei Shao, Ya Yang, Qi Zhai, Fangyu Wang & Feng Qin
Crocin is the main monomer of saffron, which is a momentous component of traditional Chinese medicine Lang Qing A Ta. Here, we tried to probe into the role of crocin in liver fibrosis. Hematoxylin-eosin staining and Sirius Red staining were used to observe the pathological changes of liver tissues. After hepatic stellate cells (HSCs) were isolated from liver tissues, lnc-LFAR1, MTF-1, GDNF, and α-SMA expressions were detected by qRT-PCR and western blot. Immunohistochemistry and immunofluorescence...

Crocin inhibits the activation of mouse hepatic stellate cells via the lnc-LFAR1/MTF-1/GDNF pathway

Ji Xuan, Dongmei Zhu, Zhengyuan Cheng, Yuping Qiu, Mei Shao, Ya Yang, Qi Zhai, Fangyu Wang & Feng Qin
Crocin is the main monomer of saffron, which is a momentous component of traditional Chinese medicine Lang Qing A Ta. Here, we tried to probe into the role of crocin in liver fibrosis. Hematoxylin-eosin staining and Sirius Red staining were used to observe the pathological changes of liver tissues. After hepatic stellate cells (HSCs) were isolated from liver tissues, lnc-LFAR1, MTF-1, GDNF, and α-SMA expressions were detected by qRT-PCR and western blot. Immunohistochemistry and immunofluorescence...

RETRACTED ARTICLE: KIAA1429 promotes osteosarcoma progression by promoting stem cell properties and is regulated by miR-143-3p

Qicai Han, Jie Yang, Hao Yang, Chao Li, Juan Li & Yuan Cao
We, the Editors and Publisher of the journal Cell Cycle, have retracted the following article: Qicai Han, Jie Yang, Hao Yang, Chao Li, Juan Li & Yuan Cao (2020) KIAA1429 promotes osteosarcoma progression by promoting stem cell properties and is regulated by miR-143-3p, Cell Cycle, 19:10, 1172-1185, DOI: 10.1080/15384101.2020.1749465 Since publication, concerns have been raised about similarity of the data in another published article: Yang J, Han Q, Li C, Yang H, Chen X, Wang...

Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress

Fan Wang, Lin Liu, Yu Tong, Linfeng Li, Yanfeng Liu & Wei-Qiang Gao
Prostate cancer (PCa) is the second commonly diagnosed malignancy in men over the world. Although androgen deprivation therapy for advanced PCa patients has significantly improved their survival, the majority of these patients eventually develop castration-resistant prostate cancer (CRPC). Proscillaridin A (Pro A), a cardiac glycoside that is clinically used to treat various heart failure diseases, has been reported to have anticancer activity in several cancers. However, whether Pro A exerts an inhibitory effect on PCa...

Identification of hepatocellular carcinoma-related genes associated with macrophage differentiation based on bioinformatics analyses

Jun Cao, Chi Zhang, Guo-Qing Jiang, Sheng-Jie Jin, Qian Wang, Ao-Qing Wang & Dou-Sheng Bai
Macrophage differentiation is associated with tumorigenesis, including the tumorigenesis of hepatocellular carcinoma (HCC). Herein, we explored the value of macrophage differentiation-associated genes (MDGs) in the prognosis of HCC using data from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) databases. We performed multivariate Cox regression analyses to identify the hub genes affecting HCC patient prognoses. The correlations between hub genes and macrophage differentiation and immune checkpoint inhibitors (PD-1, PD-L1, and CTLA4)...

Data from: Using full-length metabarcoding and DNA barcoding to infer community assembly for speciose taxonomic groups: a case study

Mengdi Hao, Qian Jin, Guanliang Meng, Caiqing Yang, Shenzhou Yang, Zhiyong Shi, Min Tang, Shanlin Liu, Yinan Li, Jing Li, Dan Zhang, Xu Su, Chungkun Shih, Yiran Sun, John James Wilson, Xin Zhou & Aibing Zhang
How insect communities are assembled in nature remains largely unknown. In particular, whether habitat filtering or competition serves as the main mechanism in forming insect communities is rarely subject to an in-depth investigation. One bottleneck lies in the difficulty of species identification when dealing with a large number of diverse insects. However, High-Throughput Sequencing (HTS) technology coupled with classic DNA barcoding offers a great opportunity to infer community assembly for this speciose group. In this...

Regional assemblages shaped by historical and contemporary factors: evidence from a species-rich insect group

Mengdi Hao, Qian Jin, Guanliang Meng, Caiqing Yang, Shenzhou Yang, Zhiyong Shi, Min Tang, Shanlin Liu, Yinan Li, Dan Zhang, Xu Su, Chungkun Shih, Yiran Sun, Xin Zhou & Ai-Bing Zhang
Understanding the complex diversity patterns is one of the main aims of community ecology. It is important to take both historical and contemporary factors into account in investigating the potential roles in assembling diversity patterns. Here, We compared diversity patterns of two moth assemblages sampled from Taihang and Yanshan mountains in Northern China and performed ancestral range reconstructions using the Multi-State-Speciation and Extinction model to track the origins of these patterns. We subsequently estimate diversification...

Swarm behavior simulation of plateau pika

Jia Yinghui, Li Fangfang, Ma Cang, Wang Guangqian & Qiu Jun
As an important species on the Qinghai-Tibet Plateau, the pika has great controversy in grassland protection and ecological function service. The population change of pika is related to the fragile and sensitive ecological chain of Qinghai-Tibet Plateau. The traditional methods of population density survey include sampling method, marker recapture method, removal sampling method, etc., which are cumbersome to operate and consume a lot of manpower and material resources. In recent years, more and more scholars...

Data from: Contrasting responses of nitrogen: phosphorus stoichiometry in plants and soils under grazing: a global meta-analysis

Rui-Peng Yu, Wei-Ping Zhang, Dario Fornara & Long Li
1. Grazing by ungulate herbivores can greatly alter nitrogen ([N]) and phosphorus ([P]) concentrations in plants and soils. It is not clear, however, how grazing might affect N:P co-limitation in grasslands depending on soil N and P availability. 2. Here we selected 173 peer-reviewed studies, which measured 12 key variables associated with changes in [N], [P] and N:P ratios (i.e. N:P stoichiometry) in soils and plants in the presence or absence of herbivore grazing. Subsequently,...

Primary Heterotopic Meningioma of Nasal Cavity: Case Report and Literature Review

Xianwen Hu, Maoyan Jiang, Zelong Feng, Juan Wang, Pan Wang & Jiong Cai
Primary heterotopic meningiomas are lesions that are not associated with a cranial nerve foramen, vertebral canal, or intracranial structure. The most common histopathological subtype is meningeal epithelioma. In clinical practice, primary heterotopic nasal meningioma occurs relatively rarely, and its most common pathological type is psammomatous meningioma, whereas nasal fibrous meningioma is infrequent. In our case, a 31-year-old male patient was admitted to the hospital with “progressive nasal obstruction on the right side for half a...

Registration Year

  • 2020
    51

Resource Types

  • Dataset
    27
  • Text
    12
  • Image
    8
  • Collection
    4

Affiliations

  • China Agricultural University
    51
  • Zhejiang University
    27
  • Fudan University
    25
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    25
  • Huazhong University of Science and Technology
    20
  • Sichuan University
    20
  • Shanghai Jiao Tong University
    20
  • Sun Yat-sen University
    19
  • Chinese Academy of Sciences
    19
  • Shandong University
    18