With the ability to observe the activity from large numbers of neurons simultaneously using modern recording technologies, the chance to identify sub-networks involved in coordinated processing increases. Sequences of synchronous spike events (SSEs) constitute one type of such coordinated spiking that propagates activity in a temporally precise manner. The synfire chain was proposed as one potential model for such network processing. Previous work introduced a method for visualization of SSEs in massively parallel spike trains,...

Objectives Severe or critical COVID-19 is associated with intensive care unit admission, increased secondary infection rate, and would lead to significant worsened prognosis. Risks and characteristics relating to secondary infections in severe COVID-19 have not been described. Methods Severe and critical COVID-19 patients from Shanghai were included. We collected lower respiratory, urine, catheters, and blood samples according to clinical necessity and culture and mNGS were performed. Clinical and laboratory data were archived. Results We found...

Als Beispiel einer globalen Krisensituation zeigt die COVID-19-Pandemie eindrucksvoll die Schwachstellen heutiger Wertschöpfungsnetzwerke. Vor dem Hintergrund zunehmend komplexer und vernetzter Wertschöpfungsnetzwerke steigt für Unternehmen die Bedeutung einer resilienten Gestaltung derselben. Dabei wird davon ausgegangen, dass ähnliche Krisensituationen in Zukunft häufiger auftreten werden. Ziel dieser Expertise ist es, Unternehmen bei der Identifikation von Potenzialen und Maßnahmen für die resiliente Gestaltung ihrer Wertschöpfungsnetzwerke zu unterstützen.

Handschriftlich überlieferte Rezepte sind unfeste Texte ohne Werkcharakter und wurden Großteiles in anonymen, häufig thematisch sortierten, Sammlungen tradiert. Der Beitrag stellt neue Methoden und Begriffe zur Erforschung der Überlieferungsgeschichte einzelner Rezepte und Rezeptsammlungen am Beispiel der kunsttechnologischen und Kochrezepte der frühneuhochdeutschen Handschrift Cod. germ. 1 der Staats- und Universitätsbibliothek Hamburg vor. Wesentlich für die Visualisierung des Rezept-Überlieferungsnetzes als Graph ist die im Vergleich zur älteren Forschung veränderte Datenstruktur. Hierbei werden die in den Handschriften materialisierten...

RWTH Aachen, Clay and Interface Mineralogy(1);RWTH Aachen, Institute for Geology and Geochemistry of Petroleum and Coal(2);Temporary underground storage of molecular hydrogen (H2) in depleted oil and gas reservoirs has recently attracted increasing research interest as it can support chemical industry demands and peak-shaving in the energy supply grid. Experimental parameters related to abiotic chemical reactions, microbial metabolism, and transport mechanisms of molecular hydrogen under elevated pressure conditions in such reservoirs are of potential relevance to...

The reaction of serpentinized peridotites with CO2-bearing fluids to listvenite (quartz-carbonate rocks) requires massive fluid flux and maintained permeability despite volume increase. Here we investigate listvenites and serpentinites samples from Hole BT1B of the Oman Drilling Project to improve our understanding of the mechanisms and feedbacks of fracturing and vein formation during peridotite carbonation. The samples are characterized by a high abundance of magnesite veins which are often bundled into closely-spaced, parallel sets. Relative cross-cutting...

Hydro-mechanical (HM) simulations are essential aspects of geothermal reservoir studies to assess the heat production and the associated-environmental impacts, such as seismicity. HM simulations are numerically expensive (especially for large-scale simulations) since they require a relatively fine mesh to capture the complex interplay between the fluid-flow and geomechanical processes. This aspect makes it difficult to perform detailed studies on uncertainties in HM simulations. In this work, we present a comprehensive review and numerical demonstrations about...

To explore the distribution law of traditional Chinese medicine (TCM) syndrome types in patients with psoriasis vulgaris complicated by metabolic disorders based on the same pathogenic factors as blood-heat and blood-stasis in the pathogenesis of psoriasis and metabolic disorders and to further analyze the correlation between adiponectin and the distribution law. From 1 January 2018 to 31 December 2019, patients diagnosed with psoriasis in the inpatient or outpatient department of Dermatology Ward of Shanghai Yueyang...

Several glacial ice advances shaped the present-day morphology of central Europe during the Quaternary. Two Pleistocene glaciations, the Elsterian and the Saalian stages, advanced as far as the north-eastern part of the onshore Netherlands. Remains of these glacial advances and retreats are deep erosional glacial valleys of the Elsterian glaciation and till sheets, glacio-tectonic ridges and glacial basins assigned to the Saalian complex. In this study, we present the effects of sequential loading and unloading...

Selbst mit ambitionierteren Maßnahmen zur Vermeidung von Emissionen lässt sich Klimaneutralität und damit die Stabilisierung der Temperatur nicht mehr erreichen. Darauf weist der Weltklimarat in seinem sechsten Sachstandsbericht hin. Zusätzlich zu einer schnelleren Reduktion der Emissionen muss CO2 der Atmosphäre entzogen und anschließend eingelagert werden, um nicht vermeidbare Restemissionen auszugleichen, etwa aus der Landwirtschaft. Sogenannte „negative Emissionen“ können zum Beispiel durch Aufforstung erzeugt werden. Es gibt aber eine Reihe weiterer natürlicher und technischer Verfahren, den...

Die Arbeitsgruppe Allianz-AG 5 „Digitales Lehren, Lernen und Vernetzen“ beschäftigt sich bereits seit einiger Zeit mit den Möglichkeiten der Verbesserung der digitalen Souveränität an den Hochschulen und in den Forschungseinrichtungen. Die Not-wendigkeit des Handelns ist durch die Gegebenheiten der Pandemie noch einmal deutlicher geworden. Folgendes Diskussionspapier richtet sich sowohl an Lehrende als auch Forschende in Wissenschaftsinstitutionen, die zur digitalen Souveränität beitragen können. Diese Institutionen sind mit der Bildung der nächsten Generation an Wissenschaftler*innen der Ort,...

Abstract There is growing interest in the use of pteropods as potential archives of past changes in ocean chemistry. However, pteropods have rarely been used in studies of millennial-scale sedimentary records, especially in shallow-marine environments. This study obtained core data for the last 16 kyr from the Northwest Shelf of Australia (NWS). Changes in the carbonate saturation state were assessed based on the carbon isotope ratios (δ13C) of shells and the Limacina dissolution index (LDX)...

Abstract Background Ribosomal biogenesis and ribosomal proteins have attracted attention in the context of tumor biology in recent years. Instead of being mere translational machineries, ribosomes might play an active role in tumor initiation and progression. Despite its importance, regulation of ribosomal biogenesis is still not completely understood. Methods Using Gene Set Enrichment Analysis of RNA sequencing and proteomical mass spectrometry data in breast cancer cells expressing Krüppel-like factor 7 (KLF7), we identified processes altered...

Additional file 1. Example of a structured observation form.

Additional file 3: Figure S3. Analysis of processes involved in ribosomal biogenesis in MCF7 cells. A) KLF7OE does not lead to significant changes in mRNA expression of the indicated genes in export, pseudouridylation, rRNA cleavage. B) No changes in POP1 and RMRP mRNA level by KLF7OE in MCF7 cells.

Additional file 3: Figure S3. Analysis of processes involved in ribosomal biogenesis in MCF7 cells. A) KLF7OE does not lead to significant changes in mRNA expression of the indicated genes in export, pseudouridylation, rRNA cleavage. B) No changes in POP1 and RMRP mRNA level by KLF7OE in MCF7 cells.

Supplemental material, sj-jpg-7-lan-10.1177_00236772221128127 for Virtual Reality in Biomedical Education in the sense of the 3Rs by Martin Lemos, Laura Bell, Susanne Deutsch, Leonie Zieglowski, Lisa Ernst, Daniel Fink, R. Tolba, Christian Bleilevens, Julia Steitz in Laboratory Animals

Sedimentary basins contain the vast majority of all energy resources, including coal, petroleum, natural gas but also geothermal energy and are also the most important storage sites for anthropogenic solids and fluids. During basin evolution, organic matter-rich sediments and sedimentary rocks are exposed to changing pressure and temperature conditions, which lead to mineralogical and geochemical reactions. Systematic and innovative studies on rock properties, laboratory experiments under well-defined physical and chemical conditions as well as numerical...

Current predictors are largely unsatisfied for early recurrence (ER) of hepatocellular carcinoma (HCC) after thermal ablation. We aimed to explore the prognostic value of peripheral immune factors (PIFs) for better ER prediction of HCC after thermal ablation. Patients who received peripheral blood mononuclear cells (PBMCs) tests before thermal ablation were included. Clinical parameters and 18 PIFs were selected to construct ModelClin, ModelPIFs and the hybrid ModelPIFs-Clin. Model performances were evaluated using area under the curve...

Additional file 1. RHC and BPA procedure.

Abstract Background The COMPERA 2.0 4-stratum (4-S) risk score has been demonstrated superior over the 3-stratum (3-S) one in patients with pulmonary arterial hypertension and medically managed patients with chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to determine the prognostic value of the original 4-S and 3-S COMPERA 2.0 risk score and two new derivative versions in CTEPH patients who underwent balloon pulmonary angioplasty (BPA). Methods We retrospectively enrolled 175 BPA-treated patients with CTEPH. We...

Abstract Background The identification of factors that specifically influence pathological and successful cognitive aging is a prerequisite for implementing disease prevention and promoting successful aging. However, multi-domain behavioral factors that characterize the difference between successful and pathological cognitive aging are not clear yet. Methods A group of community-dwelling older adults (N = 1347, aged 70-88 years) in Beijing was recruited in this cross-sectional study, and a sub-cohort was further divided into successful cognitive aging (SCA,...

Additional file 1: Table S1. Intergroup differences in demographics, health conditions, and living habits. Table S2. Intergroup differences in detailed items of leisure activities. Table S3. Results of the relative importance of influencing factors to each cognitive domain in the full sample (N = 1347). Table S4. Estimated direct and indirect effects of the grouped sample (N = 583) SEM with ECR, LLA, and four cognitive domains as latent factors. Table S5. Estimated direct and...

Abstract Background Physicians’ communication skills are important for patient-centered care. Although working with simulated patients (SPs) in case simulations is common for training communication skills, studies seldom include a wide range of challenging behaviors or explore students’ own experiences of learning communication skills with SPs. Therefore, this study was aimed at investigating how medical students perceive communication training involving challenging consultations with SPs and the impact on their learning experiences. Methods Twenty-three medical students from...

Transpulmonary thermodilution is often used to measure extravascular lung water during liver transplantation. Here, the case of new onset atrial fibrillation during orthotopic liver transplantation, which may have been induced by iced saline injection for transpulmonary thermodilution measurement, is described. A 52-year-old male patient underwent orthotopic liver transplantation due to alcoholic cirrhosis combined with portal hypertension. During dissection of the recipient liver, transpulmonary thermodilution was performed. At 3 minutes following iced saline injected, atrial fibrillation...