2 Works

Analyses on the fungus-farming termite, Macrotermes natalensis

Mark Harrison, Mireille Vassuer-Cognet, Sarah Seite, David Sillam-Dussès, Roland Lupoli, Alain Robert, Laure-Anne Poissonnier, Tom Van Dooren, Arnaud Lemainque, David Renault, Sebastien Acket, Muriel Andrieu, Jose Viscarra, Hei Sook Sul, Wilhelm De Beer & Erich Bornberg-Bauer
Kings and queens of eusocial termites can live for decades, while queens sustain a nearly maximal fertility. To investigate the molecular mechanisms underlying their long lifespan, we carried out transcriptomics, lipidomics and metabolomics in Macrotermes natalensis on sterile short-lived workers, long-lived kings and five stages spanning twenty years of adult queen maturation. Reproductives share gene expression differences from workers in agreement with a reduction of several aging-related processes, involving upregulation of DNA damage repair and...

Data from: PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex

Arman Javadi, Ravi K. Deevi, Emma Evergren, Elodie Blondel-Tepaz, George S. Baillie, Mark G.H. Scott, Frederick Charles Campbell & Mark GH Scott
PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β-Arrestin1. Because β-Arrestin1 binds and suppresses the Cdc42 GTPase-activating protein ARHGAP21, we hypothesize that PTEN controls Cdc42-dependent morphogenic processes through a β-Arrestin1-ARHGAP21 complex. Here we show that PTEN knockdown (KD) impairs β-Arrestin1 membrane localization, β-Arrestin1-ARHGAP21 interactions, Cdc42 activation, mitotic spindle orientation and 3D glandular morphogenesis....

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  • Institut Cochin
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  • University of Pretoria
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  • University of Rennes 1
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  • Genoscope
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  • French National Centre for Scientific Research
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