145 Works

The integration of large-scale public data and network analysis uncovers molecular characteristics of psoriasis

Antonio Federico, Alisa Pavel, Lena Möbus, David McKean, Giusy del Giudice, Vittorio Fortino, Hanna Niehues, Joe Rastrick, Kilian Eyerich, Stefanie Eyerich, Ellen van den Bogaard, Catherine Smith, Stephan Weidinger, Emanuele de Rinaldis & Dario Greco
Abstract In recent years, a growing interest in the characterization of the molecular basis of psoriasis has been observed. However, despite the availability of a large amount of molecular data, many pathogenic mechanisms of psoriasis are still poorly understood. In this study, we performed an integrated analysis of 23 public transcriptomic datasets encompassing both lesional and uninvolved skin samples from psoriasis patients. We defined comprehensive gene co-expression network models of psoriatic lesions and uninvolved skin....

Stability of Ceylon spinach (Basella alba L.) seed protein extract and its effect on the microbiological, chemical and sensory quality of sturgeon fillets stored at 4 °C

Ying Zhang, Qing Zhang, Liang Gao, Kang Zhou, Shang Wu, Jiawei Han & Meng Gui
The antimicrobial activity and preservative effect of Ceylon spinach (Basella alba L.) seed protein extract on sturgeon fillets stored at 4°C were investigated in this study. The results showed that Ceylon spinach seed protein extract (CSSPE) had inhibitory effect on 33 microorganisms, including 1 fungus and 32 bacteria (25 gram-negative bacteria and 7 gram-positive bacteria). In addition, CSSPE inhibited bacterial growth (total viable counts, Pseudomonas, Aeromonas and psychrotrophs), suppressed ATP degradation and retained good-quality characteristic...

Tecnica e libertà

Giuseppe Lissa
Is it the man who dispose of the technique or is the technique that the man has at his disposal? This is probably the fundamental question around which the reflection of this volume rolls around. A reflection that, in consideration of the relationship between contemporary man and technology, also proceeds in the direction of an elaborative proposal that promises the possibility of converting the freedom of the individual into responsibility. Only this step will allow,...

Stat.Edu’21 - New Perspectives in Statistics Education. Proceedings of the International Conference Stat.Edu’21

Cristina Davino, Rosa Fabbricatore & Anna Parola
[Italiano]:Il volume raccoglie i contributi presentati alla conferenza “Stat.Edu’21 -New Perspectives in Statistics Education”. La Conferenza è stata ospitata dal Dipartimento di Scienze Politiche dell’Università degli Studi di Napoli Federico II (25-26 marzo 2021). La conferenza è stata organizzata come evento finale del progetto ERASMUS+ “ALEAS - Adaptive LEArning in Statistics” (https://aleas-project.eu) che si è svolto dal 2018 al 2021. Il progetto ha avuto l’obiettivo di sviluppare e implementare un sistema di apprendimento adattivo che...

Non-simple elastic materials with double porosity structure

S. De Cicco
This paper is concerned with a strain gradient theory of elastic materials that have a double porosity structure. Firstly, we present the basic equations and the boundary conditions of the nonlinear theory. Then, we derive the equations of the linear theory and present the constitutive equations for chiral materials. The theory is applied to study the deformation of a chiral cylinder. The materials with a double porosity are of interest in geophysics and in mechanics...

Green Blue Infrastructure methodologies and design proposals

Antonio Acierno & Emanuela Coppola
The Green Blue Infrastructure is a multifunctional and flexible approach based on various layers, composing an organic network. This design methodology has the potential to recompose together fragments of the contemporary city, generating positive effects on both communities and landscape while improving the health and well-being of people and ecosystems. In this book, different project proposals are presented, facing many contexts and themes, all of which can be traced back to the theory of Green...

Broad-scale patterns of geographic avoidance between species emerge in the absence of fine-scale mechanisms of coexistence

Roberto Novella-Fernandez, Javier Juste, Carlos Ibanez, Hugo Rebelo, Danilo Russo, Antton Alberdi, Andreas Kiefer, Laura Graham, Patrick Doncaster, Hynek Paul & Orly Razgour
Aim: The need to forecast range shifts under future climate change has motivated an increasing interest in better understanding the role of biotic interactions in driving diversity patterns. The contribution of biotic interactions to shaping broad-scale species distributions is however, still debated, partly due to the difficulty of detecting their effects. We aim to test whether spatial exclusion between potentially competing species can be detected at the species range scale, and whether this pattern relates...

Additional file 2 of A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events

Andrea Cappozzo, Cathal McCrory, Oliver Robinson, Anna Freni Sterrantino, Carlotta Sacerdote, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Licia Iacoviello, Fulvio Ricceri, Sabina Sieri, Paolo Chiodini, Gareth J. McKay, Amy Jayne McKnight, Frank Kee, Ian S. Young, Bernadette McGuinness, Eileen M. Crimmins, Thalida Em Arpawong, Rose Anne Kenny, Aisling O’Halloran, Silvia Polidoro, Giuliana Solinas, Paolo Vineis, Francesca Ieva … & Giovanni Fiorito
Additional file 2. Supplementary Tables S1, S2, and S3.

Additional file 1 of Floral organ transcriptome in Camellia sasanqua provided insight into stamen petaloid

Menglong Fan, Xinlei Li, Ying Zhang, Si Wu, Zhixin Song, Hengfu Yin, Weixin Liu, Zhengqi Fan & Jiyuan Li
Additional file 1: Table S1. Summary of sequencing quality.

Additional file 3 of Floral organ transcriptome in Camellia sasanqua provided insight into stamen petaloid

Menglong Fan, Xinlei Li, Ying Zhang, Si Wu, Zhixin Song, Hengfu Yin, Weixin Liu, Zhengqi Fan & Jiyuan Li
Additional file 3: Table S3. The KEGG enrichment analysis of comparison analysis.

Additional file 3 of Floral organ transcriptome in Camellia sasanqua provided insight into stamen petaloid

Menglong Fan, Xinlei Li, Ying Zhang, Si Wu, Zhixin Song, Hengfu Yin, Weixin Liu, Zhengqi Fan & Jiyuan Li
Additional file 3: Table S3. The KEGG enrichment analysis of comparison analysis.

Additional file 4 of Floral organ transcriptome in Camellia sasanqua provided insight into stamen petaloid

Menglong Fan, Xinlei Li, Ying Zhang, Si Wu, Zhixin Song, Hengfu Yin, Weixin Liu, Zhengqi Fan & Jiyuan Li
Additional file 4: Table S4. The gene description list of the model.

Additional file 6 of Floral organ transcriptome in Camellia sasanqua provided insight into stamen petaloid

Menglong Fan, Xinlei Li, Ying Zhang, Si Wu, Zhixin Song, Hengfu Yin, Weixin Liu, Zhengqi Fan & Jiyuan Li
Additional file 6: Table S6. The KEGG enrichment analysis of coexpression modules.

Additional file 8 of Floral organ transcriptome in Camellia sasanqua provided insight into stamen petaloid

Menglong Fan, Xinlei Li, Ying Zhang, Si Wu, Zhixin Song, Hengfu Yin, Weixin Liu, Zhengqi Fan & Jiyuan Li
Additional file 8: Figure S1. The correlation analysis of RNA-seq data.

sj-pdf-1-smm-10.1177_09622802221129861 - Supplemental material for A general method for calculating power for GEE analysis of complete and incomplete stepped wedge cluster randomized trials

Ying Zhang, John S Preisser, Elizabeth L Turner, Paul J Rathouz, Mark Toles & Fan Li
Supplemental material, sj-pdf-1-smm-10.1177_09622802221129861 for A general method for calculating power for GEE analysis of complete and incomplete stepped wedge cluster randomized trials by Ying Zhang, John S Preisser, Elizabeth L Turner, Paul J Rathouz, Mark Toles and Fan Li in Statistical Methods in Medical Research

Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Fabian Eichelmann, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote … & Vivian Viallon
Abstract Background Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations. Methods We analysed targeted metabolomics data available for 5828 matched case-control pairs from cancer-specific case-control studies on breast, colorectal, endometrial, gallbladder, kidney, localized and advanced prostate cancer, and hepatocellular carcinoma nested...

Active human full-length CDKL5 produced in the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125

Andrea Colarusso, Concetta Lauro, Marzia Calvanese, Ermenegilda Parrilli & Maria Luisa Tutino
Abstract Background A significant fraction of the human proteome is still inaccessible to in vitro studies since the recombinant production of several proteins failed in conventional cell factories. Eukaryotic protein kinases are difficult-to-express in heterologous hosts due to folding issues both related to their catalytic and regulatory domains. Human CDKL5 belongs to this category. It is a serine/threonine protein kinase whose mutations are involved in CDKL5 Deficiency Disorder (CDD), a severe neurodevelopmental pathology still lacking...

University in the fight against mafias. Research, teaching and training

Stefano D'Alfonso & Gaetano Manfredi
The commitment of Italian universities to education in the field of legality and to research on the subject of mafias is the main focus of this investigation edited by Stefano D’Alfonso and Gaetano Manfredi. For the first time, data is shown about the overall framework of teaching and research activities dedicated to this topic, with twenty-nine scholars from different academic disciplines and several universities who come together to reflect on the current situation and on...

“Better late than never but never late is better”, especially in young women. A multicenter Italian study on diagnostic delay for symptomatic endometriosis

Ida Pino, Gaia Maria Belloni, Valeria Barbera, Eugenio Solima, Davide Radice, Stefano Angioni, Saverio Arena, Valentino Bergamini, Massimo Candiani, Antonio Maiorana, Alberto Mattei, Ludovico Muzii, Luca Pagliardini, Maria Grazia Porpora, Valentino Remorgida, Renato Seracchioli, Paolo Vercellini, Fulvio Zullo, Errico Zupi & Michele Vignali
The aim of the study was to assess the length of diagnostic delay of symptomatic endometriosis in Italy and analyse the presence of correlations between the socio-demographic status of patients and the clinical characteristics/type of diagnosis. This multicenter cross-sectional questionnaire-based study was conducted in 10 tertiary Italian referral centres for diagnosis and treatment endometriosis. A total of 689 respondents with histologically proven endometriosis and onset of the disease with pain symptoms completed an on-line self-reported...

sj-pdf-1-vmj-10.1177_1358863X221130378 – Supplemental material for Consistent smoking and development of arterial stiffening in adult men: Results of the Olivetti Heart Study

Lanfranco D’Elia, Maria Masulli, Roberto Iacone, Ornella Russo, Pasquale Strazzullo & Ferruccio Galletti
Supplemental material, sj-pdf-1-vmj-10.1177_1358863X221130378 for Consistent smoking and development of arterial stiffening in adult men: Results of the Olivetti Heart Study by Lanfranco D’Elia, Maria Masulli, Roberto Iacone, Ornella Russo, Pasquale Strazzullo and Ferruccio Galletti in Vascular Medicine

sj-pdf-1-vmj-10.1177_1358863X221130378 – Supplemental material for Consistent smoking and development of arterial stiffening in adult men: Results of the Olivetti Heart Study

Lanfranco D’Elia, Maria Masulli, Roberto Iacone, Ornella Russo, Pasquale Strazzullo & Ferruccio Galletti
Supplemental material, sj-pdf-1-vmj-10.1177_1358863X221130378 for Consistent smoking and development of arterial stiffening in adult men: Results of the Olivetti Heart Study by Lanfranco D’Elia, Maria Masulli, Roberto Iacone, Ornella Russo, Pasquale Strazzullo and Ferruccio Galletti in Vascular Medicine

The characterization and expression analysis under stress conditions of PCST1 in Arabidopsis

Hao Zhang, Ke Zhang, Tongtong Liu, Ying Zhang, Ziyan Tang, Jingao Dong & Fengru Wang
Analysis of PCST1 expression characteristics and the role of PCST1 in response to osmotic stress in Arabidopsis thaliana. The structure of PCST1 was analyzed using Bioinformatics method. Real-time PCR, GUS tissue localization and subcellular localization were adopted to analyze the expression pattern of PCST1 in Arabidopsis. To validate the transgenic positive strain of PCST1 using Real-time PCR, overexpression experiments were performed in wild type. Full-length cDNA was cloned and connected into a binary vector with...

An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation

Gabriella Ferretti, Alessia Romano, Rossana Sirabella, Sara Serafini, Thorsten Jürgen Maier & Carmela Matrone
Abstract Background Semaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons during development. In particular, Class 3 Sema (Sema 3) is among the best characterized Sema family members and the only produced as secreted proteins in mammals, thereby exerting both autocrine and paracrine functions. Intriguingly, an increasing number of studies supports the crucial role of the Sema 3A in hippocampal and cortical neurodevelopment. This means that alterations in Sema...

Additional file 1 of An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation

Gabriella Ferretti, Alessia Romano, Rossana Sirabella, Sara Serafini, Thorsten Jürgen Maier & Carmela Matrone
Additional file 1: Table S1. Key Resource Table. Table S2. Dendritic branching analysis of Figure 1E. Data are the mean ± SEM of three independent experiments in triplicate. Two-way ANOVA followed by Tukey’s test for multiple comparisons. *P < 0.05; **P < 0,01; ****P < 0,0001 vs Ctrl and #P<0.05 vs Sema 3A + siNpn 1.

Update on novel antipsychotics and pharmacological strategies for treatment-resistant schizophrenia

Andrea de Bartolomeis, Mariateresa Ciccarelli, Licia Vellucci, Michele Fornaro, Felice Iasevoli & Annarita Barone
Treatment resistant schizophrenia (TRS), the lack of response to at least two antipsychotics administered at adequate dose and duration, epitomizes in psychiatry one of the most difficult-to-treat pathologies, epidemiologically relevant (affecting one-third of schizophrenia patients) and with severe consequences for the patients in terms of overall functioning. After 50 years, only one drug is approved for TRS: clozapine. Furthermore, a few patients do not respond even to clozapine and are indicated as clozapine-resistant patients. In...

Registration Year

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Affiliations

  • University of Naples Federico II
    145
  • National University of Singapore
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  • Chinese University of Hong Kong
    39
  • Henan University
    38
  • North West Agriculture and Forestry University
    38
  • West China Hospital of Sichuan University
    38
  • Cancer Hospital of Shantou University Medical College
    38
  • Central South University
    38
  • Georgetown University Medical Center
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  • Fudan University Shanghai Cancer Center
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