In this paper, a ring-core trench-assisted few-mode bismuth-doped fiber amplifier (FM-BDFA) is simulated on the basis of the threeenergy level. The fiber is designed to support four modes of signal group transmission for practical considerations, including LP01, LP11, LP21, and LP31. The results suggest that (1) it is possible to obtain gain equalization of the three signal groups by using the LP21 mode pump independently, where the maximum difference in modal gain (MAX DMG) is...
Identification of downstream targets and signaling pathways of long non-coding RNA NR_002794 in human trophoblast cellsYinyao Ma, Hua Wu, Xuxia Liang, Chun Zhang, Yanhua Ma, Yanfen Wei, Jing Li & Hui Chen
Preeclampsia (PE) is a huge threat to pregnant women. Our previous study demonstrated that long non-coding RNA (lncRNA) NR_002794 was highly expressed in placentas of PE patients and could regulate the phenotypes of trophoblast cells. However, the downstream regulatory mechanisms of NR_002794 remain unknown. In this text, some potential downstream targets or signaling pathways of NR_002794 were identified through RNA sequencing (RNA-seq) and bioinformatics analysis in SWAN71 trophoblast cells. Western blot assay demonstrated that NR_002794...
Data from: Comparison of the genetic determinism of two key phenological traits, flowering and maturity dates, in three Prunus species: peach, apricot and sweet cherryPatrick Lambert, David Ruiz, Luca Dondini, Eudald Illa, Jean-Marc Audergon, Stefano Tartarini, Philippe Letourmy, Elisabeth Dirlewanger, José Quéro-Garcia, Loïck Le Dantec, Bénédicte Quilot-Turion & Pere Arus
The present study investigates the genetic determinism of flowering and maturity dates, two traits highly affected by global climate change. Flowering and maturity dates were evaluated on five progenies from three Prunus species, peach, apricot and sweet cherry, during three to eight years. Quantitative trait locus (QTL) detection was performed separately for each year and also by integrating data from all years together. High heritability estimates were obtained for flowering and maturity dates. Several QTLs...
Data from: Wide variation in spatial genetic structure between natural populations of the European beech (Fagus sylvatica) and its implications for SGS comparabilityAlistair S. Jump, Laura Rico, Marta Coll & Josep Peñuelas
Identification and quantification of spatial genetic structure (SGS) within populations remains a central element of understanding population structure at the local scale. Understanding such structure can inform on aspects of the species' biology, such as establishment patterns and gene dispersal distance, in addition to sampling design for genetic resource management and conservation. However, recent work has identified that variation in factors such as sampling methodology, population characteristics, and marker system can all lead to significant...
The pig, Sus scrofa, is a foreign species to the American continent. Although pigs originally introduced in the Americas should be related to those from the Iberian Peninsula and Canary islands, the phylogeny of current creole pigs that now populate the continent is likely to be very complex. Because of the extreme climates that America harbours, these populations also provide a unique example of a fast evolutionary phenomenon of adaptation. Here, we provide a genome...
Genes with relevant roles in the differentiation of closely-related species are likely to have diverged simultaneously with the species and more accurately reproduce the species tree. The Lusitanian (Microtus lusitanicus) and Mediterranean (M. duodecimcostatus) pine voles are two recently separated sister species with fossorial lifestyles whose different ecological, physiological and morphological phenotypes reflect the better adaptation of M. duodecimcostatus to the underground habitat. Here we asked whether the differentiation of M. lusitanicus and M. duodecimcostatus...
Data from: Heat tolerance in Drosophila subobscura along a latitudinal gradient: contrasting patterns between plastic and genetic responsesLuis E. Castañeda, Enrico L. Rezende & Mauro Santos
Susceptibility to global warming relies on how thermal tolerances respond to increasing temperatures through plasticity or evolution. Climatic adaptation can be assessed examining the geographic variation in thermal-related traits. We studied latitudinal patterns in heat tolerance in Drosophila subobscura reared at two temperatures. We used four static stressful temperatures to estimate the thermal death time curves (TDT), and two ramping assays with fast and slow heating rates. TDT curves allow estimating the critical thermal maximum...
Evolutionary change of thermal traits (i.e. heat tolerance and behavioral thermoregulation) is one of the most important mechanisms exhibited by organisms to respond to global warming. However, the evolutionary potential of heat tolerance, estimated as narrow-sense heritability, depends on the methodology employed. An alternative adaptive mechanism to buffer extreme temperatures is behavioral thermoregulation, although the association between heat tolerance and thermal preference is not clearly understood. We suspect that methodological effects associated with the duration...
Angelo Monforte’s Letter to Peter of Aragon and the Early Dissemination of Decembrio’s Translation of Curtius RufusMontserrat Ferrer
This note establishes that in 1438 Angelo Monforte, count of Campobasso, sent to Prince Peter of Aragon a copy of Pier Candido Decembrio’s Italian version of Curtius Rufus, thus documenting the transmission of Decembrio’s work from Milan to Naples. This copy could have been the source of Alfonso de Liñán’s translation into Spanish of Decembrio’s translation.
Data from: Partitioning between atmospheric deposition and canopy microbial nitrification into throughfall nitrate fluxes in a Mediterranean forestRossella Guerrieri, Lucas Lecha, Stefania Mattana, Joan Cáliz, Emilio Casamayor, Anna Barceló, Greg Michalski, Josep Penuelas, Anna Àvila & Maurizio Mencuccini
1. Microbial activity plays a central role in nitrogen (N) cycling, with effects on forest productivity. Though N bio-transformations, such as nitrification, are known to occur in the soil, here we investigate whether nitrifiers are present in tree canopies and actively process atmospheric N. 2. This study was conducted in a Mediterranean holm oak (Quercus ilex L.) forest in Spain during the transition from hot dry summer to cool wet winter. We quantified NH4+—N and...
Two new diploid species, Aira minoricensis and Aira hercynica are described and illustrated, along with chromosome counts, risk assessment, distribution and habitat, phenology, and comparisons with morphologically similar species. A comparative table and a key for the species of Aira for the Iberian Peninsula and the Balearic Islands are provided to assist in the identification of these overlooked species, and their relationships to other taxa are discussed.
Dataset and scripts from: Predicting temperature mortality and selection in natural Drosophila populationsEnrico Rezende, Francisco Bozinovic, András Szilágyi & Mauro Santos
The study develops and validates a theoretical model to predict thermal mortality under natural conditions, based on measurements of mortality performed in the laboratory at multiple constant temperatures. The theoretical model first fits a thermal tolerance landscape, which describes how survival probability is affected by both temperature and exposure time, to the empirical measurements of mortality obtained in the laboratory under controlled conditions. Then, employing a numerical approximation to the analytical solution based on differential...
Estimation of the relative abundance of species in artificial mixtures of insects using low-coverage shotgun metagenomicsLidia Garrido-Sanz, Miquel Àngel Senar & Josep Piñol
Amplicon metabarcoding is an established technique to analyse the taxonomic composition of communities of organisms using high-throughput DNA sequencing, but there are doubts about its ability to quantify the relative proportions of the species, as opposed to the species list. Here, we bypass the enrichment step and avoid the PCR-bias, by directly sequencing the extracted DNA using shotgun metagenomics. This approach is common practice in prokaryotes, but not in eukaryotes, because of the low number...
Influence of socio-economic, demographic and climate factors on the regional distribution of dengue in the United States and MexicoMatthew Watts
Climate change, urbanization, and global trade have contributed to the recent spread of dengue viruses. In this study, we investigate the relationship between dengue occurrence in humans, climate factors (temperature and minimum quarterly rainfall), socio-economic factors (such as household income, regional rates of education, regional unemployment, housing overcrowding, life expectancy, and medical resources), and demographic factors (such as migration flows, age structure of the population, and population density). From a geographical perspective, this study focuses...
Effects of soil salinity on the expression of direct and indirect defences in wild cotton (Gossypium hirsutum)Luis Abdala-Roberts, Teresa Quijano-Medina, Ted Turlings, Paula Sosenski, Luca Grandi, Jose Cervera & Xoaquin Moreira
Previous studies have reported effects of abiotic factors on herbivore-induced plant defences based on effects on single plant traits. However, plants commonly express multiple defences simultaneously and these traits are often correlated. Thus, a fuller understanding of abiotic-context dependency in plant defence requires measuring multiple traits and addressing their patterns of correlated expression. We evaluated the effects of soil salinity on the induction of direct (phenolic compounds, gossypol gland density) and indirect (volatile organic compounds,...
Background: During their workday, nurses face a variety of stressors that are dealt with using different coping strategies. One criticism of the contextual models of work stress is that they fail to focus on individual responses like coping with stress. Neverthless, little is know about the momentary determinants of coping in nurses. Objectives: To identify the momentary predictors of problem-focused approaching coping and emotion-focused approaching coping, as well as those for seeking social support and...
1. Facilitation by nurse plants increases understorey diversity and supports ecological communities. In turn, biodiversity shapes ecological networks and enhances ecosystem functioning. However, whether and how facilitation and increased biodiversity jointly influence community structure and ecosystem functioning remains unclear. 2. We performed a field experiment disentangling the relative contribution of nurse plants and increasing understorey plant diversity in driving pollination interactions. Both the presence of nurse shrubs as well as increased understorey plant diversity increased...
Facile approach for surfactant-free synthesis of Au@ginsenoside Rh2 nanoparticles and researches on anticancer activityHua Yao, Xupeng Mu, Zhenhong Wei, Xiuying Li, Liya Wu, Yongri Jin, Xuwen Li, Jing Li & Jinlan Jiang
Abstract Background Inorganic nanocomposites especially Au nanostructures have exhibited outstanding physicochemical properties in biomedical fields. For further clinical applications on theranostics, especially drug delivery, numerous explorations of green and facile synthesis methods combining with pharmacoactive natural components have been investigated to construct safe and multifunctional bioactive Au nanoparticles (NPs). Ginsenoside Rh2 is protopanaxadiol type compound isolated from plants of genus Panax, with excellent anticancer effect and antioxidant activity. In this research, we prepared the novel...
Additional file 2 of In the presence of non-neutralising maternally derived antibodies, intradermal and intramuscular vaccination with a modified live vaccine against porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) induce similar levels of neutralising antibodies or interferon-gamma secreting cellsLaia Aguirre, Yanli Li, Massimiliano Baratelli, Gerard Martín-Valls, Martí Cortey, Joel Miranda, Marga Martín & Enric Mateu
Supplementary Material 2
Additional file 1 of In the presence of non-neutralising maternally derived antibodies, intradermal and intramuscular vaccination with a modified live vaccine against porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) induce similar levels of neutralising antibodies or interferon-gamma secreting cellsLaia Aguirre, Yanli Li, Massimiliano Baratelli, Gerard Martín-Valls, Martí Cortey, Joel Miranda, Marga Martín & Enric Mateu
Supplementary Material 1
Additional file 2 of Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patientsYan Li, Lili Chen, Jinxing Lv, Xiaobin Chen, Bangwei Zeng, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Jing Li, Peng Zhou, Wenzhe Zhang, Shengmei Li, Xuan Jin, Weifeng Cai, Kun Zhang, Yeyuan Huang, Chuan Wang & Fangmeng Fu
Supplementary Material 2
Additional file 1 of AGI grade-guided chaiqin chengqi decoction treatment for predicted moderately severe and severe acute pancreatitis (CAP trial): study protocol of a randomised, double-blind, placebo-controlled, parallel-group, pragmatic clinical trialZhiyao Chen, Xiaonan Yang, Jia Guo, Tao Jin, Ziqi Lin, Ping Zhu, Jing Li, Ling Li, Xin Sun, Dan Du, Kun Jiang, Yanqiu He, Fei Cai, Lan Li, Cheng Hu, Qingyuan Tan, Wei Huang, Lihui Deng & Qing Xia
Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents.
Supplementary document for Vari-focal liquid microlens array using electrically responsive fluid actuated by ring array patterned electrode - 6102065.pdfMiao Xu, Yating Liu, Senhao Li, Jing Li, Lyudi Zhang & Hongbo Lu
Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patientsJesus Pujol, Laura Blanco-Hinojo, Andrea Doreste, Fabiola Ojeda, Gerard Martínez-Vilavella, Víctor Pérez-Sola, Joan Deus & Jordi Monfort
Abstract Background Pain-sensitized osteoarthritis and fibromyalgia patients characteristically show nociceptive system augmented responsiveness as a common feature. However, sensitization can be originally related to the peripheral injury in osteoarthritis patients, whereas pain and bodily discomfort spontaneously occur in fibromyalgia with no apparent origin. We investigated the distinct functional repercussion of pain sensitization in the cerebral cortex in both conditions. Methods Thirty-one pain-sensitized knee osteoarthritis patients and 38 fibromyalgia patients were compared with matched control groups....
sj-docx-2-whe-10.1177_17455057221130566 – Supplemental material for Endometriosis prevalence and incidence trends in a large population-based study in Catalonia (Spain) from 2009 to 2018Laura Medina-Perucha, Andrea Pistillo, Berta Raventós, Constanza Jacques-Aviñó, Jordina Munrós-Feliu, Cristina Martínez-Bueno, Carme Valls-Llobet, Francisco Carmona, Tomàs López-Jiménez, Georgina Pujolar-Díaz, Eva Flo Arcas, Anna Berenguera & Talita Duarte-Salles
Supplemental material, sj-docx-2-whe-10.1177_17455057221130566 for Endometriosis prevalence and incidence trends in a large population-based study in Catalonia (Spain) from 2009 to 2018 by Laura Medina-Perucha, Andrea Pistillo, Berta Raventós, Constanza Jacques-Aviñó, Jordina Munrós-Feliu, Cristina Martínez-Bueno, Carme Valls-Llobet, Francisco Carmona, Tomàs López-Jiménez, Georgina Pujolar-Díaz, Eva Flo Arcas, Anna Berenguera and Talita Duarte-Salles in Women’s Health
Autonomous University of Barcelona287
Washington University in St. Louis150
State Administration of Traditional Chinese Medicine of the People's Republic of China142
Chinese Academy of Tropical Agricultural Sciences142
Hebei Normal University142
North West Agriculture and Forestry University142
Sun Yat-sen University142
Jiangxi Agricultural University142
Beijing University of Chemical Technology142