Charakterisierung der Hybridsensorkinase LuxN und des Antwortregulators LuxO des Quorum sensing-Systems in Vibrio harveyiTina Odenbach
Die Signaltransduktionskaskade des komplexen Quorum sensing-Systems in Vibrio harveyi umfasst die drei Hybridsensorkinasen LuxN, LuxQ und CqsS, das Histidinphosphotransferprotein LuxU und den Antwortregulator LuxO. Bei niedriger Zelldichte funktionieren die Hybridsensorkinasen als Autokinasen. Die Phosphorylgruppe wird zunächst intramolekular übertragen und anschließend auf LuxU und LuxO weitergeleitet. Phosphoryliertes LuxO aktiviert die Expression von fünf regulatorischen RNAs, die im Zusammenspiel mit dem RNA-Chaperon Hfq die Translation der mRNA des Masterregulators LuxR inhibieren. Bei hoher Zelldichte wird die Kinaseaktivität...
What types of human-animal interspecific entities are used in biomedical research? Is creating such entities morally wrong? And what do interspecifics tell us about the moral significance of species? This thesis offers an introduction to the field of human-animal interspecifics from a bioethical perspective, with a special focus on the question of speciesism.
This study offers a comprehensive overview of post-millennial Indian (English) and Latin American crime fiction. Drawing on genre theory and the field of literature & globalization, Neele Meyer examines the history of crime fiction and traces similar developments in the book markets in these largely disconnected regions. In an analysis of the characteristics of the genre, the author studies the works of 17 writers from India, Argentina and Chile focusing on aspects like detective figures...
While investigation techniques and image modalities become more and more advanced, radiology reports have remained in their classic form for the past decades. Structured reporting has shown its potential to increase the clarity, correctness, confidence, concision, completeness, consistency, communication, consultation and standardization of radiology reports. The increased report quality can mostly be attributed to a complete checklist like approach, standardized vocabulary through RadLex and RSNA provided templates which can be adapted to address very specific...
Characterization of ECF42, a novel group of extracytoplasmic function (ECF) σ factors with C‑terminal regulatory extensionsQiang Liu
Extracytoplasmic function (ECF) σ factors represent the third most abundant fundamental principle of bacterial signal transduction, outnumbered only by one- and two-component systems. A recent census of ECF σ factors revealed a large number of novel groups whose functions and regulatory mechanisms have not yet been elucidated. Here we report the characterization of members of the novel group ECF42. ECF42 σ factors are a highly abundant and widely distributed ECF group that is present in...
Ludwig Maximilian University of Munich118
Sun Yat-sen University111
Guangdong Provincial Hospital of Traditional Chinese Medicine111
North West Agriculture and Forestry University107
Shanghai University of Traditional Chinese Medicine105
Guangzhou Medical University105