1,559 Works

Genetic data from: Cryptic persistence and loss of local endemism in Lake Constance charr subject to anthropogenic disturbance

Ulrich Schliewen, Jan Baer, Frederic Schedel, Nicolas Straube, Samuel Roch & Alexander Brinker
Habitat restoration can help to protect and support endangered species. Following the restoration of Lake Constance to oligotrophic conditions, deep-water charr (originally described as Salvelinus profundus Schillinger, 1901) were rediscovered after more than 40 years of presumed extinction caused by eutrophication. Subsequent targeted surveys lead to the capture of a further 127 deep-water charr and 233 sympatric normal charr, Salvelinus cf. umbla. Given a history of intensive stocking in the lake and the possibility of...

Untersuchungen zur EtG-Kinetik

Khatera Ayni-Ahadi
In dieser Arbeit geht es um die kinetischen Betrachtungen – Invasionskinetik und die Eliminationskinetik – die dazu dienen, Trinkeinlassungen zu beurteilen. Außerdem soll ermittelt werden, ob eine Behauptung zu einer konkreten Alkoholaufnahme mittels EtGWert verifiziert oder falsifiziert werden kann.

The role of cathepsin L in shaping a functional CD4 T cell repertoire

Elisabetta Petrozziello

Additional file 2 of EVI1 expression in early-stage breast cancer patients treated with neoadjuvant chemotherapy

Jonas Leichsenring, Valentina Vladimirova, Christine Solbach, Thomas Karn, Beyhan Ataseven, Bruno Valentin Sinn, Jana Barinoff, Volkmar Müller, Jens-Uwe Blohmer, Christian Schem, Knut Engels, Frederik Marmé, Annette Fisseler-Eckhoff, Peter A. Fasching, Elmar Stickeler, Marion van Mackelenbergh, Carsten Denkert, Albrecht Stenzinger, Sibylle Loibl & Stefan Gröschel
Additional file 2: Supplementary Figure 2. Distribution of EVI1 continuous expression in breast cancer: A: Histogram of EVI1 continuous expression in the entire cohort (N=993); B: Boxplots of EVI1 continuous expression within breast cancer subtypes. Note, 882/993 patients with available BC subtype information were included in this analysis. Horizontal bold lines present EVI1 median values of 116.65 in HR+/HER2-, 98.67 in HR+/HER2+, 114.77in HR-/HER2+, and 115.64 in TNBC; boxes present the interquartile range between first...

EVI1 expression in early-stage breast cancer patients treated with neoadjuvant chemotherapy

Jonas Leichsenring, Valentina Vladimirova, Christine Solbach, Thomas Karn, Beyhan Ataseven, Bruno Valentin Sinn, Jana Barinoff, Volkmar Müller, Jens-Uwe Blohmer, Christian Schem, Knut Engels, Frederik Marmé, Annette Fisseler-Eckhoff, Peter A. Fasching, Elmar Stickeler, Marion van Mackelenbergh, Carsten Denkert, Albrecht Stenzinger, Sibylle Loibl & Stefan Gröschel
Abstract Background Overexpression of the EVI1 (ecotropic viral integration site 1) oncogene has recently been implicated as a prognostic factor in breast cancer (BC), particularly in triple-negative BC (TNBC). In this study we aimed to investigate frequency and clinical relevance of EVI1 expression in newly diagnosed BC treated with neoadjuvant chemotherapy. Methods EVI1 expression was determined by immunohistochemistry using H-score as a cumulative measurement of protein expression in pretherapeutic biopsies of BC patients treated with...

Untersuchungen zur entzündungsbedingten Regulation der Interleukine IL1B und IL1RA im Uterus des Rindes

Anna Maria Kneidl

Enhanced stability of foot-and-mouth disease vaccine antigens with a novel formulation

Jing Li, Rong Zhang, Huiqing Yang & Yanming Wei
The structural instability of inactivated Foot-and-mouth disease virus antigen hinders the development of vaccine industry. The use of an inexpensive, biocompatible formulation to slow down the degradation of antigen would address the problem. Here, phosphate-buffered saline (PBS) was showed to be effective in stabilizing 146S and hence determined as basic solution buffer. Excipients such as trehalose, sucrose, arginine, cysteine, calcium chloride, BSA and ascorbic acid were found to protect 146S from massive structural breakdown. Using...

Botulinum toxin treatment for bielschowsky acquired commitant esotropia in adults

Likun Ai, Xiaoli Chen, Ruilin Guo, Jing Li, Jinghui Wang, Yi Feng, Yiqin Guo & Jianan Wang
Abstract Background Many researchers have noticed that there is an increasing trend of Bielschowsky acquired comitant esotropia (ACE) in recent years related to excessive near work, but the exact pathogenesis and treatment methods have not been reported yet. Therefore, we aimed to characterize the clinical features of this ACE in adults and to evaluate the efficacy of botulinum toxin (BTX) injections in these patients. Methods This was a prospective consecutive case series of 47 patients...

Botulinum toxin treatment for bielschowsky acquired comitant esotropia in adults

Likun Ai, Xiaoli Chen, Ruilin Guo, Jing Li, Jinghui Wang, Yi Feng, Yiqin Guo & Jianan Wang
Abstract Background Many researchers have noticed that there is an increasing trend of Bielschowsky acquired comitant esotropia (ACE) in recent years related to excessive near work, but the exact pathogenesis and treatment methods have not been reported yet. Therefore, we aimed to characterize the clinical features of this ACE in adults and to evaluate the efficacy of botulinum toxin (BTX) injections in these patients. Methods This was a prospective consecutive case series of 47 patients...

Vaskuläre Netzhauterkrankungen

Thomas Kreutzer

Bedeutung von Cysteinyl-Leukotrienen und Prostanoiden in der Pathogenese der portalen Hypertension durch aktivierte Kupfferzellen

Mark op den Winkel
Basierend auf den Ergebnissen klinischer Studien müssen bakterielle Infektionen als Trigger akuter Ösophagusvarizenblutungen bei Patienten mit Leberzirrhose angenommen werden. Hierfür werden Permeabilitätsstörungen der Darmwand als Folge der portalen Hypertonie verantwortlich gemacht, die eine Einschwemmung pathogener Darmkeime in die portale Zirkulation begünstigen. Kupffer'sche Sternzellen (KS), die residenten Makrophagen der Leber, kommen nicht nur als größte sondern auch als erste Makrophagenpopulation des menschlichen Körpers mit pathogenen Darmbakterien in Kontakt. Durch bakterielle Bestandteile wie Endotoxine oder die in...

Antigen-spezifische memory B-Lymphozyten in der Transplantation - Immunophänotypisierung im Impfmodell und die Rolle von memory B- Lymphozyten in der Immunantwort

Simon Johannes Theiner
Antigen-spezifische memory B-Lymphozyten in der Transplantation - Immunophänotypisierung im Impfmodell und die Rolle von memory B-Lymphozyten in der Immunantwort In der Therapie des terminalen Organversagens, stellt die Transplantation solider Organe die derzeit beste Therapieoption dar. Das Langzeitüberleben des Grafts ist jedoch noch immer nicht zufriedenstellend. Es hat sich herausgestellt, dass memory B-Lymphozyten gegen diverse Alloantigene des Grafts bereits vor einer Transplantation im Empfänger präformiert sein können, jedoch mit der üblichen Antikörperdiagnostik nicht detektiert werden. Deshalb...

Makulachirurgie bei myoper Foveoschisis

Stefan Stefanov

Essays on fiscal policy

Marcell Göttert

Model-agnostic interpretable machine learning

Christoph Molnar

Role of Coronin 1B on the regulation of endothelial cell function and angiogenesis

Ann-Cathrin Werner

Einsatz der Positronen-Emissions-Tomographie mit [18F]FDG für die Diagnostik von neurodegenerativen Erkrankungen aus dem frontotemporalen Formenkreis

Johanna Meyer-Wilmes
FDG-PET als Maß für neuronale Schädigung wird bei verschiedenen neurodegenerativen Erkrankungen aus dem frontotemporalen Formenkreis diagnostisch eingesetzt. In der weiterführenden Diagnostik kommen darüber hinaus spezifische Radiotracer zum Einsatz. Hierbei befindet sich die Tau-PET aktuell in klinischer Erprobung. In der dargestellten Arbeit konnte bei Patienten mit T+ APS bei zwei Dritteln der Patienten eine zufriedenstellende Diagnosesicherheit erzielt werden. Ein Drittel der Patienten würde demnach von einer weiteren Bewertung mit spezifischeren Radioliganden profitieren. Bei Patienten mit Verdacht...

Successful cemented femoral arthroplasties reveal very often stiffened bone structures

Christophe Draenert
Background: PMMA bone cements represent one of the oldest biomaterials used in general and orthopedic surgery since 1938. The use and application still raise questions with respect to osseointegration and long-lasting behavior in combination with artificial implants. Objectives: The study focuses on the following questions: Why do some implants last for many years and others do not, can bone embedded in bone cement survive, will heat gener- ated by the exothermic reaction yield a necrosis...

Stellenwert der Verlaufsbeobachtung, operativen Tumorresektion und Monochemotherapie bei Oligodendrogliomen WHO Grad II

Jonathan Weller
INTRODUCTION Gliomas of histological WHO grades 2 and 3 show a heterogenous prognosis that largely depends on molecular tumor characteristics. Presence of 1p/19q codeletions distinguishes oligodendroglioma from astrocytoma among IDHmut gliomas. Both entities are associated with favourable outcome when compared to IDHwt WHO grade 2 and 3 astrocytomas with molecular features of glioblastomas, e.g., pTERTmut (which are now referred as glioblastoma). We here investigated different therapies in WHO grade 2 oligodendrogliomas (Publication I) and assessed...

Regulation of transcription and stability of repetitive DNA in S. pombe

Thomas van Emden
Repetitive DNA is found in all kingdoms of life and in many species makes up a substan-tial portion of the genome. Repetitive DNA has many functions, such as: regulatory roles, encoding for long non-coding RNA and it makes up structural components of chromo-some. On the other hand, repetitive DNA is unstable and thus a threat to genome stability. Therefore, repetitive DNA needs to be controlled; however, many aspects of this regula-tion remain elusive. The genome...

Vom Machiavellismus zur Hospitalisierung – Expertokratie oder Mündigkeit im Zeitalter der Digitalisierung

Hans-Martin Schönherr-Mann

Micro- and macroadenomas causing primary aldosteronism: molecular and biochemical studies

Yuhong Yang
Aldosterone-producing adenomas are the surgically correctable form of primary aldosteronism. Next generation sequencing targeted to aldosterone-producing adenomas with positive expression of CYP11B2 has unveiled the existence of somatic mutations and explained aldosterone overproduction. However, pathogenic mechanisms contributing to the diverse adenoma sizes and the associated biochemical features remain largely unclear. In this thesis, we utilized steroid and transcriptome profiling of aldosterone-producing adenomas of distinctly different diameter (micro and macro aldosterone-producing adenomas) to identify circulating biomarkers...

Notch2 signaling in B cell plasticity

Markus Lechner
B cells are a type of lymphocyte immune cells with important functions in humoral immunity of the adaptive immune system and are responsible for the production of antibodies. B cells also account for malignancies and autoimmune disorders. For a better understanding and treatment of these diseases, the respective B cell functions and last not least their development and origin are of crucial importance. Murine peripheral B cells can be separated into B1 and B2 cells,...

Der Einfluss von Komorbiditäten auf das Therapieergebnis von Patienten mit adjuvanter Strahlentherapie bei Kopf-Hals-Tumoren

Nora Franziska Thomsen
Hintergrund: Weltweit stellen Tumore der Kopf-Hals-Region (HNC) die sechsthäufigste Tumorerkrankung dar. Die wichtigsten Risikofaktoren für die Entstehung eines HNC sind Tabak- und Alkoholkonsum sowie zunehmend eine Infektion mit HPV. Neben HPV-Status gelten Tumorausbreitung und Lymphknotenmetastasen als wichtige Prognosefaktoren. Ein einheitliches onkologisches Assessment für Patienten mit HNC existiert bislang nicht. Der Einfluss patientenspezifischer Prognosefaktoren ist Gegenstand aktueller Forschung. Die vorliegende Studie wird retrospektiv ein onkologisches Assessment mittels dreier Komorbiditätsindizes durchführen: Der ASA-Klassifikation (American Society of Anesthesiologists),...

Registration Year

  • 2022
    1,559

Resource Types

  • Dissertation
    1,160
  • Text
    199
  • Dataset
    86
  • Collection
    85
  • Image
    14
  • Audiovisual
    6
  • Report
    3
  • Other
    2
  • Software
    2
  • Book Chapter
    1
  • Journal Article
    1

Affiliations

  • Ludwig-Maximilians-Universität München
    1,553
  • Sun Yat-sen University
    104
  • Guangdong Provincial Hospital of Traditional Chinese Medicine
    104
  • North West Agriculture and Forestry University
    100
  • Zhejiang University
    100
  • Fudan University
    100
  • Beihang University
    98
  • Shanghai University of Traditional Chinese Medicine
    98
  • Guangzhou Medical University
    98
  • Xi'an Jiaotong University
    98