9 Works

Data from: Imposed work of breathing for flow meters with in-line versus flow-through technique during simulated neonatal breathing

Snorri Donaldsson, Markus Falk, Baldvin Jonsson & Thomas Drevhammar
Background: The ability to determine airflow during nasal CPAP (NCPAP) treatment without adding dead space or resistance would be useful when investigating the physiologic effects of different NCPAP systems on breathing. The aim of this study was to investigate the effect on pressure stability of different flow measuring devices at the in-line and flow-through position, using simulated neonatal breathing. Methods: Six different flow measure devices were evaluated by recording pressure changes and imposed work of...

Data from: A multi-breed genome-wide association analysis for canine hypothyroidism identifies a shared major risk locus on CFA12

Matteo Bianchi, Stina Dahlgren, Jonathan Massey, Elisabeth Dietschi, Marcin Kierczak, Martine Lund-Ziener, Katarina Sundberg, Stein Istre Thoresen, Olle Kämpe, Göran Andersson, William E. R. Ollier, Åke Hedhammar, Tosso Leeb, Kerstin Lindblad-Toh, Lorna J. Kennedy, Frode Lingaas & Gerli Rosengren Pielberg
Bianchi, Dahlgren et al., Canine Hypothyroidism data

Data from: The effects of spatial structure, frequency dependence and resistance evolution on the dynamics of toxin-mediated microbial invasions

Ben Libberton, Malcolm J. Horsburgh & Michael A. Brockhurst
Recent evidence suggests that interference competition between bacteria shapes the distribution of the opportunistic pathogen Staphylococcus aureus in the lower nasal airway of humans, either by preventing colonization or by driving displacement. This competition within the nasal microbial community would add to known host factors that affect colonization. We tested the role of toxin-mediated interference competition in both structured and unstructured environments, by culturing S. aureus with toxin-producing or nonproducing Staphylococcus epidermidis nasal isolates. Toxin-producing...

Data from: Genome-Wide Analyses Suggest Mechanisms Involving Early B-Cell Development in Canine IgA Deficiency

Mia Olsson, Katarina Tengvall, Marcel Frankowiack, Marcin Kierczak, Kerstin Bergvall, Erik Axelsson, Linda Tintle, Eliane Marti, Petra Roosje, Tosso Leeb, Åke Hedhammar, Lennart Hammarström & Kerstin Lindblad-Toh
Immunoglobulin A deficiency (IgAD) is the most common primary immune deficiency disorder in both humans and dogs, characterized by recurrent mucosal tract infections and a predisposition for allergic and other immune mediated diseases. In several dog breeds, low IgA levels have been observed at a high frequency and with a clinical resemblance to human IgAD. In this study, we used genome-wide association studies (GWAS) to identify genomic regions associated with low IgA levels in dogs...

Data from: The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome

Laurence D. Hurst, Avazeh T. Ghanbarian, Alistair R. R. Forrest, Fantom Consortium & Lukasz Huminiecki
X chromosomes are unusual in many regards, not least of which is their nonrandom gene content. The causes of this bias are commonly discussed in the context of sexual antagonism and the avoidance of activity in the male germline. Here, we examine the notion that, at least in some taxa, functionally biased gene content may more profoundly be shaped by limits imposed on gene expression owing to haploid expression of the X chromosome. Notably, if...

Data from: Flight-induced changes in gene expression in the Glanville fritillary butterfly

Jouni Kvist, Anniina I. K. Mattila, Panu Somervuo, Virpi Ahola, Patrik Koskinen, Lars Paulin, Leena Salmela, Toby Fountain, Pasi Rastas, Annukka Ruokolainen, Minna Taipale, Liisa Holm, Petri Auvinen, Rainer Lehtonen, Mikko J. Frilander, Ilkka Hanski & Anniina L. K. Mattila
Insect flight is one of the most energetically demanding activities in the animal kingdom, yet for many insects flight is necessary for reproduction and foraging. Moreover, dispersal by flight is essential for the viability of species living in fragmented landscapes. Here, working on the Glanville fritillary butterfly (Melitaea cinxia), we use transcriptome sequencing to investigate gene expression changes caused by 15 min of flight in two contrasting populations and the two sexes. Male butterflies and...

Data from: Effect of host plant and immune challenge on the levels of chemosensory and odorant-binding proteins in caterpillar salivary glands

Maria De La Paz Celorio-Mancera, A. Jimmy Ytterberg, Dorothea Rutishauser, Niklas Janz & Roman A. Zubarev
More than half of the proteome from mandibular glands in caterpillars is represented by chemosensory proteins. Based on sequence similarity, these proteins are putative transporters of ligands to gustatory receptors in sensory organs of insects. We sought to determine whether these proteins are inducible by comparing, both qualitatively and quantitatively, the salivary (mandibular and labial) proteomes from caterpillars (Vanessa cardui) reared on different plants and artificial diet containing either bacteria or bacterial cell-walls. We included...

Data from: Identification of quantitative genetic components of fitness variation in farmed, hybrid and native salmon in the wild

Francois Besnier, Kevin A. Glover, Sigbjørn Lien, Matthew Kent, Michael M. Hansen, Xia Shen & Øystein Skaala
Feral animals represent an important problem in many ecosystems due to interbreeding with wild conspecifics. Hybrid offspring from wild and domestic parents are often less adapted to local environment and ultimately, can reduce the fitness of the native population. This problem is an important concern in Norway, where each year, hundreds of thousands of farm Atlantic salmon escape from fish farms. Feral fish outnumber wild populations, leading to a possible loss of local adaptive genetic...

Data from: Disruption of memory reconsolidation erases a fear memory trace in the human amygdala: An 18-month follow-up

Johannes Björkstrand, Thomas Agren, Andreas Frick, Jonas Engman, Elna-Marie Larsson, Tomas Furmark & Mats Fredrikson
Fear memories can be attenuated by reactivation followed by disrupted reconsolidation. Using functional magnetic resonance imaging we recently showed that reactivation and reconsolidation of a conditioned fear memory trace in the basolateral amygdala predicts subsequent fear expression over two days, while reactivation followed by disrupted reconsolidation abolishes the memory trace and suppresses fear. In this follow-up study we demonstrate that the behavioral effect persists over 18 months reflected in superior reacquisition after undisrupted, as compared...

Registration Year

  • 2015
    9

Resource Types

  • Dataset
    9

Affiliations

  • Karolinska Institute
    9
  • Uppsala University
    3
  • University of Bern
    2
  • Swedish University of Agricultural Sciences
    2
  • Broad Institute
    2
  • Stockholm University
    2
  • University of Bath
    1
  • Karolinska University Hospital
    1
  • University of Manchester
    1
  • University of Helsinki
    1