8 Works

Data from: Immunohistochemical typing of adenocarcinomas of the pancreatobiliary system improves diagnosis and prognostic stratification

Carlos Fernandez Moro, Alejandro Fernandez-Woodbridge, Melroy Alistair D'souza, Qianni Zhang, Benedek Bozoky, Senthil Vasan Kandaswamy, Piera Catalano, Rainer Heuche, Sonia Shtembari, Marco Del Chiaro, Olof Danielsson, Mikael Björnstedt, J. Matthias Löhr, Bengt Isaksson, Caroline Verbeke, Béla Bozóky & Rainer Heuchel
Background & Aims: Adenocarcinomas of the pancreatobiliary system are currently classified by their primary anatomical location. In particular, the pathological diagnosis of intrahepatic cholangiocarcinoma is still considered as a diagnosis of exclusion of metastatic adenocarcinoma. Periampullary cancers have been previously classified according to the histological type of differentiation (pancreatobiliary, intestinal), but overlapping morphological features hinder their differential diagnosis. We performed an integrative immunohistochemical analysis of pancreato-biliary tumors to improve their diagnosis and prediction of outcome....

Data from: Continuum of vasodilator stress from rest to contrast medium to adenosine hyperemia for fractional flow reserve assessment

Nils P. Johnson, Allen Jeremias, Frederik M. Zimmermann, Julien Adjedj, Nils Witt, Barry Hennigan, Bon-Kwon Koo, Akiko Maehara, Mitsuaki Matsumura, Emanuele Barbato, Giovanni Esposito, Bruno Trimarco, Gilles Rioufol, Seung-Jung Park, Hyoung-Mo Yang, Sérgio B. Baptista, George S. Chrysant, Antonio M. Leone, Colin Berry, Bernard De Bruyne, K. Lance Gould, Richard L. Kirkeeide, Keith G. Oldroyd, Nico H. J. Pijls, William F. Fearon … & Nico H.J. Pijls
OBJECTIVES: We compared the diagnostic performance with adenosine-derived fractional flow reserve (FFR) #0.8 of contrast-based FFR (cFFR), resting distal pressure (Pd)/aortic pressure (Pa), and the instantaneous wave-free ratio (iFR). BACKGROUND: FFR objectively identifies lesions that benefit from medical therapy versus revascularization. However, FFR requires maximal vasodilation, usually achieved with adenosine. Radiographic contrast injection causes submaximal coronary hyperemia. Therefore, intracoronary contrast could provide an easy and inexpensive tool for predicting FFR. METHODS: We recruited patients undergoing...

Data from: Reliability and construct validity of the Psychopathic Personality Inventory-Revised in a Swedish non-criminal sample: a multimethod approach including psychophysiological correlates of empathy for pain

Karolina Sörman, Gustav Nilsonne, Katarina Howner, Sandra Tamm, Shilan Caman, Hui-Xin Wang, Martin Ingvar, John F. Edens, Petter Gustavsson, Scott O. Lilienfeld, Predrag Petrovic, Håkan Fischer & Marianne Kristiansson
Cross-cultural investigation of psychopathy measures is important for clarifying the nomological network surrounding the psychopathy construct. The Psychopathic Personality Inventory-Revised (PPI-R) is one of the most extensively researched self-report measures of psychopathic traits in adults. To date however, it has been examined primarily in North American criminal or student samples. To address this gap in the literature, we examined PPI-R’s reliability, construct validity and factor structure in non-criminal individuals (N = 227) in Sweden, using...

Data from: Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication

Tim Schulte
Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental stress. This disruption mechanism was largely explained through nsP3-mediated recruitment of the host G3BP protein via two tandem FGDF motifs. Here, we present the 1.9 Å resolution crystal structure of the NTF2-like domain of G3BP-1 in complex with a 25-residue peptide derived...

Data from: Parallel telomere shortening in multiple body tissues owing to malaria infection

Muhammad Asghar, Vaidas Palinauskas, Nadège Zaghdoudi-Allan, Gediminas Valkiūnas, Andrey Mukhin, Elena Platonova, Anna Färnert, Staffan Bensch & Dennis Hasselquist
Several studies have shown associations between shorter telomere length in blood and weakened immune function, susceptibility to infections, and increased risk of morbidity and mortality. Recently, we have shown that malaria accelerates telomere attrition in blood cells and shortens lifespan in birds. However, the impact of infections on telomere attrition in different body tissues within an individual is unknown. Here, we tested whether malarial infection leads to parallel telomere shortening in blood and tissue samples...

Data from: A rare study from the wintering grounds provides insight into the costs of malaria infection for migratory birds

Marjorie C. Sorensen, Muhammad Asghar, Staffan Bensch, Graham D. Fairhurst, Susanne Jenni-Eiermann & Claire N. Spottiswoode
Malaria parasites can have strong effects on the population dynamics and evolution of migratory bird species. In many species, parasite transmission occurs on the wintering grounds, but studies to determine the consequences of infection have taken place during the breeding season, when malaria parasites circulate at chronic levels. We examined the predictors of malarial infections for great reed warblers during the northern winter in Africa, where active parasite transmission is thought to occur and naïve...

Data from: An analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modes

Hamdah Shafqat-Abbasi, Jacob M. Kowalewski, Alexa Kiss, Xiaowei Gong, Pablo Hernandez-Varas, Ulrich Berge, Mehrdad Jafari-Mamaghani, John G. Lock & Staffan Strömblad
Mesenchymal (lamellipodial) migration is heterogeneous, although whether this reflects progressive variability or discrete, 'switchable' migration modalities, remains unclear. We present an analytical toolbox, based on quantitative single-cell imaging data, to interrogate this heterogeneity. Integrating supervised behavioral classification with multivariate analyses of cell motion, membrane dynamics, cell-matrix adhesion status and F-actin organization, this toolbox here enables the detection and characterization of two quantitatively distinct mesenchymal migration modes, termed 'Continuous' and 'Discontinuous'. Quantitative mode comparisons reveal differences...

Data from: Oral microflora in preschool children attending a fluoride varnish program: a cross-sectional study

Maria Anderson, Margaret Grindefjord, Göran Dahllöf, Gunnar Dahlén & Svante Twetman
Background: To compare the oral microflora in preschool children attending a fluoride varnish program with a reference group receiving a standard oral health program without fluoride varnish applications. A second aim was to relate the microbial composition to the caries prevalence. Methods: Five hundred seven 3-year-old children were enrolled from a cohort of 3403 preschool children taking part in a community based oral health project. Two hundred sixty-three of them had attended caries-preventive program with...

Registration Year

  • 2016

Resource Types

  • Dataset


  • Karolinska Institute
  • Lund University
  • INTEGRIS Baptist Medical Center
  • Stanford University
  • Columbia University
  • Karolinska University Hospital
  • University of Glasgow
  • University of Saskatchewan
  • University of Cambridge
  • Texas A&M University