13 Works

Data from: Infant CPAP for low-income countries: an experimental comparison of standard bubble CPAP and the Pumani system

Markus Falk, Snorri Donaldsson & Thomas Drevhammar
Introduction: Access to inexpensive respiratory support to newborn infants improves survival in low-income countries. Standard bubble continuous positive airway pressure (CPAP) has been extensively used worldwide for more than 30 years. One project aimed at providing affordable CPAP is the Pumani system developed by Rice 360. Compared to standard bubble CPAP the system has an unconventional design. The aim was to compare the Pumani system with two traditional bubble CPAP systems, focusing on in-vitro performance...

Data from: RPASE: individual based allele-specific expression detection without prior knowledge of haplotype phase

Mi Wang, Severin Uebbing, Yudi Pawitan & Douglas G. Scofield
Variation in gene expression is believed to make a significant contribution to phenotypic diversity and divergence. The analysis of allele-specific expression (ASE) can reveal important insights into gene expression regulation. We developed a novel method called RPASE (Read-backed Phasing-based ASE detection) to test for genes that show ASE. With mapped RNA-seq data from a single individual and a list of SNPs from the same individual as the only input, RPASE is capable of aggregating information...

Data from: High serum MMP-14 predicts worse survival in gastric cancer

Aaro Kasurinen, Taina Tervahartiala, Alli Laitinen, Arto Kokkola, Timo Sorsa, Camilla Böckelman & Caj Haglund
Matrix metalloproteinases (MMPs), endopeptidases with diverse biochemical functions, can promote cancer cell invasion and metastasis by degrading the extracellular matrix. A high matrix metalloproteinase-14 (MMP-14) expression in gastric cancer tissue has been associated with metastasis and poor prognosis. To further understand this association, we investigated serum MMP-14 as a biomarker in gastric cancer patients. The patient cohort consisted of 240 gastric adenocarcinoma patients who underwent surgery at Helsinki University Hospital, Finland, between 2000 and 2009....

Data from: Increased CAIDE dementia risk, cognition, CSF biomarkers and vascular burden in healthy adults

Mirian Ecay-Torres, Ainara Estanga, Mikel Tainta, Andrea Izagirre, Maite Garcia-Sebastian, Jorge Villanua, Montserrat Clerigue, Ane Iriondo, Iratxe Urreta, Arantzazu Arrospide, Carmen Díaz-Mardomingo, Miia Kivipelto & Pablo Martinez-Lage
Objective: To investigate the cognitive profile of healthy individuals with increased CAIDE dementia risk score, and to explore whether this association is related to vascular burden and CSF biomarkers of amyloidosis and neurodegeneration. Method: Cognitively normal participants (mean age = 57.6 years) from the Gipuzkoa Alzheimer Project study were classified as having high risk (HR, n = 82) or low risk (LR, n = 293) for dementia according to a CAIDE score cut off of...

Data from: Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage

Marketa Kaucka, Julian Petersen, Marketa Tesarova, Bara Szarowska, Maria Eleni Kastriti, Meng Xie, Anna Kicheva, Karl Annusver, Maria Kasper, Orsolya Symmons, Leslie Pan, Francois Spitz, Jozef Kaiser, Maria Hovorakova, Tomas Zikmund, Kazunori Sunadome, Michael P. Matise, Hui Wang, Ulrika Marklund, Hind Abdo, Patrik Ernfors, Pascal Maire, Maud Wurmser, Andrei S. Chagin, Kaj Fried … & Igor Adameyko
Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal capsule, whereas the formation of a capsule roof is controlled by signals from the olfactory epithelium. Unexpectedly,...

Data from: Multimodal MRI suggests that male homosexuality may be linked to cerebral midline structures

Amirhossein Manzouri & Ivanka Savic
The neurobiology of sexual preference is often discussed in terms of cerebral sex dimorphism. Yet, our knowledge about possible cerebral differences between homosexual men (HoM), heterosexual men (HeM) and heterosexual women (HeW) are extremely limited. In the present MRI study we addressed this issue investigating measures of cerebral anatomy and function, which were previously reported to show sex difference. Specifically, we asked whether there were any signs of sex atypical cerebral dimorphism among HoM, if...

Data from: Reproductive and behavior dysfunction induced by maternal androgen exposure and obesity is likely not gut microbiome-mediated

Lisa Lindheim, Maria Manti, Romina Fornes, Mina Bashir, Paulo Czarnewski, Oscar E Diaz, Maike Seifert, Lars Engstrand, Eduardo J Villablanca, Barbara Obermayer-Pietsch & Elisabet Stener-Victorin
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder of unclear etiology in women and is characterized by androgen excess, insulin resistance, and mood disorders. The gut microbiome is known to influence conditions closely related with PCOS, and several recent studies have observed changes in the stool microbiome of women with PCOS. The mechanism by which the gut microbiome interacts with PCOS is still unknown. We used a mouse model to investigate if...

Data from: Quantification of endogenous and exogenous protein expressions of Na,K-ATPase with super-resolution PALM/STORM imaging

Kristoffer Bernhem, Hans Blom & Hjalmar Brismar
Transient transfection of fluorescent fusion proteins is a key enabling technology in fluorescent microscopy to spatio-temporally map cellular protein distributions. Transient transfection of proteins may however bypass normal regulation of expression, leading to overexpression artefacts like misallocations and excess amounts. In this study we investigate the use of STORM and PALM microscopy to quantitatively monitor endogenous and exogenous protein expression. Through incorporation of an N-terminal hemagglutinin epitope to a mMaple3 fused Na,K-ATPase (α1 isoform), we...

Data from: Chorea, psychosis, acanthocytosis, and prolonged survival associated with ELAC2 mutations

Martin Paucar, Aleksandra Pajak, Christoph Freyer, Åsa Bergendal, Margit Döry, Jose M. Laffita-Mesa, Henrik Stranneheim, Kristina Lagerstedt-Robinson, Irina Savitcheva, Ruth H. Walker, Anna Wedell, Anna Wredenberg & Per Svenningsson
Biallelic mutations in the elaC ribonuclease Z 2 (ELAC2) gene cause a rare mitochondrial disease, the main features of which are hypertrophic cardiomyopathy, delayed psychomotor development, and usually death during childhood. Only 20 families have been reported with this syndrome. Neither movement disorders nor psychotic features have been described as part of the spectrum of ELAC2 mutations. We describe a patient with a complex hyperkinetic syndrome and acanthocytosis, harboring biallelic ELAC2 mutations.

Data from: Brain myo-inositol as a potential marker of amyloid-related pathology: a longitudinal study.

Olga Voevodskaya, Konstantinos Poulakis, Pia Sundgren, Danielle Van Westen, Sebastian Palmqvist, Lars Olof Wahlund, Erik Stomrud, Oskar Hansson & Eric Westman
Objective: To investigate the association between longitudinal changes in proton magnetic spectroscopy (MRS) metabolites and amyloid pathology in non-demented individuals; to explore the relationship between MRS and cognitive decline. Methods: In this longitudinal multiple time point study (a subset of the Swedish BioFINDER) we included cognitively healthy participants, individuals with subjective cognitive decline and mild cognitive impairment (MCI). MRS was acquired serially in 294 participants (670 individual spectra) from the posterior cingulate/precuneus. Using mixed-effects models,...

Data from: Effects of working-memory training on striatal dopamine release

Lars Backman, Lars Nyberg, Anna Soveri, Jarkko Johansson, Micael Andersson, Erika Dahlin, Anna S. Neely, Jere Virta, Matti Laine & Juha O. Rinne
Updating of working memory has been associated with striato-frontal brain regions and phasic dopaminergic neurotransmission. We assessed raclopride binding to striatal dopamine (DA) D2 receptors during a letter-updating task and a control condition before and after 5 weeks of updating training. Results showed that updating affected DA activity before training and that training further increased striatal DA release during updating. These findings highlight the pivotal role of transient neural processes associated with D2 receptor activity...

Data from: Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood

Nicole Toepfner, Christoph Herold, Oliver Otto, Philipp Rosendahl, Angela Jacobi, Martin Kräter, Julia Stächele, Leonard Menschner, Maik Herbig, Laura Ciuffreda, Lisa Ranford-Cartwright, Michal Grzybek, Ünal Coskun, Elisabeth Reithuber, Genevieve Garriss, Peter Mellroth, Birgitta Henriques Normark, Nicola Tregay, Meinolf Suttorp, Martin Bornhäuser, Edwin R. Chilvers, Reinhard Berner, Jochen Guck, Birgitta Henriques-Normark & Leonhard Menschner
Blood is arguably the most important bodily fluid and its analysis provides crucial health status information. A first routine measure to narrow down diagnosis in clinical practice is the differential blood count, determining the frequency of all major blood cells. What is lacking to advance initial blood diagnostics is an unbiased and quick functional assessment of blood that can narrow down the diagnosis and generate specific hypotheses. To address this need, we introduce the continuous,...

Data from: Body odour disgust sensitivity predicts authoritarian attitudes

Marco Tullio Liuzza, Torun Lindholm, Caitlin B. Hawley, Marie Gustafsson-Sendén, Ingrid Ekström & Jonas K. Olofsson
Authoritarianism has resurfaced as a research topic in political psychology, as it appears relevant to explain current political trends. Authoritarian attitudes have been consistently linked to feelings of disgust, an emotion that is thought to have evolved to protect the organism from contamination. We hypothesized that body odour disgust sensitivity (BODS) might be associated with authoritarianism, as chemo-signalling is a primitive system for regulating interpersonal contact and disease avoidance, which are key features also in...

Registration Year

  • 2018

Resource Types

  • Dataset


  • Karolinska Institute
  • Karolinska University Hospital
  • Stockholm University
  • University of Pennsylvania
  • University of Glasgow
  • European Molecular Biology Laboratory
  • Lund University
  • University of Cambridge
  • Turku PET Centre
  • King's College London